4.6 Article

Chemistry and the missing era of evolution

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CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 13, 页码 3830-3839

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200701215

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chemical biology; crystal growth; directed evolution; enzymes; inorganic chemistry

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The Darwinian evolution of life on earth depends utterly on complex molecular machinery, which, it seems, could only have arisen through a Darwinian evolution. The RNA world idea reduces this paradox, but requires a geochemically implausible supply of RNA monomers. A pre-RNA era of natural selection is implied. I suggest that originally this was based on inorganic materials that came to replicate permutations with specific (e.g. catalytic) effects.

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