Article
Neurosciences
Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert, Eric E. Smith
Summary: This study investigated the association between mild behavioral impairment (MBI) in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and found that adding MBI to MCI can better identify AD and improve dementia prognostication. Therefore, the addition of MBI is important for the detection of AD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Neurosciences
Akram A. Hosseini, Thomas Brown, Luca Mannino, Bruno Gran, Kehinde Junaid, Elizabeta B. Mukaetova-Ladinska
Summary: This study conducted diagnostic lumbar puncture in patients with early onset Alzheimer's or related dementias and evaluated the measurements of amyloid-beta 42 (A beta(42)), total tau, and Thr181-phosphorylated tau (p-tau) in the cerebrospinal fluid (CSF). The results showed that low levels of CSF A beta(42) appear to be more sensitive than total and p-tau measures in differentiating AD MCI from other forms of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Olivier Hanon, Jean-Sebastien Vidal, Sylvain Lehmann, Stephanie Bombois, Bernadette Allinquant, Christiane Baret-Rose, Jean-Marc Treluyer, Hendy Abdoul, Patrick Gele, Christine Delmaire, Frederic Blanc, Jean-Francois Mangin, Luc Buee, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elena Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe Robert, Olivier Godefroy, Vincent Camus, Joel Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Susanna Schraen-Maschke, Audrey Gabelle
Summary: This study found that a threshold of plasma Aβ(1-42)/Aβ(1-40) ratio can predict the risk of conversion to dementia in patients with mild cognitive impairment (MCI) within 3 years.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Yunxing Ma, Julia Brettschneider, Joanna F. Collingwood
Summary: Levels of amyloid-beta and tau in human cerebrospinal fluid were evaluated to predict the transition from Mild Cognitive Impairment to Alzheimer's disease. The results support the value of amyloid-beta and tau as markers of patient outcome.
Review
Neurosciences
Elena Sagues-Sese, Jose Rioja, Francisco J. Garzon-Maldonado, Manuel Narvaez, Juan A. Garcia-Arnes, Natalia Garcia-Casares
Summary: This systematic review provides an overview of the state-of-the-art knowledge about insulin-related cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) and mild cognitive impairment (MCI). The results indicate decreased levels of CSF insulin and increased levels of insulin-related growth factors and their binding proteins.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Cell Biology
Amish Gaur, Luc Rivet, Ethan Mah, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Krista L. Lanctot
Summary: Mild cognitive impairment (MCI) is an early stage of dementia (such as Alzheimer's disease) that is accompanied by neurodegenerative signs. This study evaluated potential fluid biomarkers in MCI and found that elevated levels of NfL and GFAP can be detected in both cerebrospinal fluid (CSF) and peripheral blood. Monitoring these biomarkers may provide important insights into the underlying neurodegenerative processes in MCI.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Hao Hu, Jun-Ting Fu, Yan-Lin Bi, Ya-Hui Ma, Yu-Yuan Huang, Xin Wang, Lan Tan, Jin-Tai Yu
Summary: This study found an association between cigarette smoking and cognitive impairment as well as tau pathologies. The effects of smoking on cognition and tau pathologies worsened with greater cumulative cigarette exposure, independent of A beta pathology. Smoking was found to have a partial mediation effect on cognition through tau pathologies. Long-term smoking cessation was found to mitigate both cognitive impairment and tau pathologies.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Federico Verde, Edoardo Nicolo Aiello, Ilaria Milone, Eleonora Giacopuzzi Grigoli, Antonella Dubini, Antonia Ratti, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani
Summary: This study compared the distribution of T +/- profiles among A+patients with MCI and dementia. The results showed that A+T+ profiles were predominant in both groups, contradicting the common notion of A+T- profiles being more prevalent in MCI patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Brenda Chino-Vilca, Inmaculada Concepcion Rodriguez-Rojo, Lucia Torres-Simon, Pablo Cuesta, Anna Carnes Vendrell, Gerard Pinol-Ripoll, Raquel Huerto, Nuria Tahan, Fernando Maestu
Summary: The study aims to evaluate the correlations between electroencephalography (EEG) and cerebrospinal fluid (CSF) markers in mild cognitive impairment (MCI) population. The findings indicate a negative correlation between A β-42 load and central-posterior theta power, as well as a negative correlation between t-tau and widespread alpha power in males. In females, there is a significant negative correlation between t-tau and widespread beta power.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Wataru Araki, Kazutomi Kanemaru, Kotaro Hattori, Tadashi Tsukamoto, Yuko Saito, Sumiko Yoshida, Harumasa Takano, Masuhiro Sakata, Yuma Yokoi, Yoshie Omachi, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Hisateru Tachimori, Shigeo Murayama, Hidehiro Mizusawa
Summary: The study found that concentrations of sAPPα and sAPPβ in the CSF of MCI-AD patients were significantly higher than in MCI patients due to other causes, and these sAPP concentrations were highly correlated with p-tau levels, indicating a potential role for these proteins in the precise diagnosis of MCI.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Lorenzo Maria Del Re, Giulia Giacomucci, Juri Balestrini, Assunta Ingannato, Valentina Moschini, Carmen Morinelli, Giulia Galdo, Cristina Polito, Camilla Ferrari, Gastone Pansini, Alessandro Della Puppa, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: Patients with idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's Disease (AD) show similar levels of CSF A beta(42), but the levels of A beta(42)/A beta(40), p-tau, and t-tau are significantly different and can accurately distinguish iNPH from AD. A beta(42)/A beta(40) is the most important variable for differentiation. Positive A beta(42)/A beta(40) in iNPH, especially when associated with positive p-tau, may indicate the presence of coexistent AD pathology.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Analytical
Menglin Zhou, Tingfan Tang, Danfeng Qin, Hao Cheng, Xinzhong Wang, Jianbing Chen, Thomas Wagberg, Guangzhi Hu
Summary: An octahedral metal-organic framework, MIL-100, was synthesized and hematite nanoparticles were assembled on its surface to develop an electrochemical sensor for sensitive detection of paraquat (PQ). The Fe2O3-MIL-100-based sensor showed excellent sensing performance with a linear response range of 0.01-30 μM and a limit of detection of 2.6 nM. It also exhibited high sensitivity and selectivity for PQ detection in milk and honey samples, making it an effective tool for rapid detection of PQ in foods.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemistry & Molecular Biology
Tahereh Sohrabi, Behnaz Mirzaei-Behbahani, Ramin Zadali, Mitra Pirhaghi, Ludmilla A. Morozova-Roche, Ali Akbar Meratan
Summary: Parkinson's disease (PD) is a common neurological movement disorder characterized by the loss of dopaminergic neurons in the brain. A misfolded protein called a-synuclein (a-syn) has been identified as a key factor in the development of PD. This review discusses the mechanisms by which a-syn dysfunction leads to mitochondrial dysfunction, and the potential therapeutic approaches, such as antioxidant-based therapy, in PD treatment. The review emphasizes the importance of understanding the role of mitochondrial dysfunction in PD pathogenesis.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Engineering, Chemical
Xiuxiu Jia, Xue Zhao, Zenghui Bi, Hucai Zhang, Shuquan Huang, Jason Chun-Ho Lam, Wenyan Li, Yongtao Li, Thomas Wagberg, Guangzhi Hu
Summary: In this study, a rod-shaped lanthanum oxychloride decorated porous carbon material, Polyvinylpyrrolidone /LaOCl (PL), was successfully prepared using a novel freeze-drying thermal oxidation method. PL exhibited excellent performance in removing phosphorus (P) from water, with a high adsorption capacity of 90.9 mg P/g and a removal rate exceeding 92.0% over a wide pH range (2.5-11). This study provides a theoretical basis for the preparation of new P adsorbents and technical support for preventing water eutrophication.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Energy & Fuels
Erik Zall, Mikael Jarn, Stefan Karlsson, Henrik Tryggeson, Mikko Tuominen, Mikael Sundin, Thomas Wagberg
Summary: This paper describes the development of antireflective mesoporous silica coatings on low-iron float glass using the aerosol-based nFOGTM deposition technique. The experimental results show that these coatings have the optimal thickness and improved antireflection effect, making them suitable for solar glass applications.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2023)
Article
Chemistry, Physical
Ziyao Li, Mengshan Chen, Lei Zhang, Rui Xing, Jinsong Hu, Xinhua Huang, Chunhui Zhou, Yingtang Zhou, Thomas Wagberg, Guangzhi Hu
Summary: This study presents an atomic-level orbital coupling strategy to effectively regulate the electronic structures of ultra-small tri-metal Fe-Co-Ni nanoalloy particles. The nanoalloy hybrid material exhibited notable bi-functional catalytic performances toward the oxygen reduction reaction and oxygen evolution reaction, surpassing precious-metal-based and previously reported catalysts. In addition, the as-assembled Zn-air device displayed superior specific capacity, maximal power density, and impressive durability.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Xue Zhao, Jianbing Chen, Zenghui Bi, Songqing Chen, Ligang Feng, Xiaohai Zhou, Haibo Zhang, Yingtang Zhou, Thomas Wagberg, Guangzhi Hu
Summary: By combining morphological control engineering and diatomic coupling strategies, heteronuclear Fe-Co bimetals can be efficiently intercalated into nitrogen-doped carbon materials, forming a star-like structure, which can simultaneously accelerate the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The FeCoNC/SL catalyst driven ORR exhibits higher half-wave potential and kinetic current density than the commercial Pt/C catalyst. The OER overpotential is as low as 316 mV (eta(10)), and the mass activity is at least 3.2 and 9.4 times that of mononuclear CoNC/SL and FeNC/SL, respectively. The Zn-air battery with FeCoNC/SL as the air cathode shows a high power density of 224.8 mW cm(-2) and a specific capacity of 803 mAh g(-1).
Article
Chemistry, Multidisciplinary
Qiyu Hu, Shoushun Chen, Thomas Wagberg, Hongshan Zhou, Shujun Li, Yiding Li, Yilan Tan, Wenqi Hu, Yong Ding, Xinbao Han
Summary: A general approach to the direct insolubilization of a water-soluble polyoxometalate (POM) and the formation of a series of POM-based solid catalysts with different counter-cations is reported. These solid POM catalysts exhibit improved catalytic activities for visible-light-driven water oxidation and good stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Zhicheng Nie, Mengshan Chen, Lei Zhang, Qing Feng, Jinsong Hu, Xinhua Huang, Chunhui Zhou, Yingtang Zhou, Thomas Wagberg, Guangzhi Hu
Summary: A Fe-Ni alloy catalyst was synthesized by the rational design of electronic-structure modulation through nano-alloying, with the alloy particles embedded in an N-doped carbon nanobox. The catalyst showed superior performance compared to commercial noble-metal benchmarks, with a decent half-wave potential of 0.891 V for ORR and a small overpotential of 325 mV at 10 mA/cm2 for OER in 0.1 M KOH solution. Additionally, a highly-efficient regenerative Zn-air battery was successfully constructed, exhibiting a small potential gap of 0.664 V, high specific capacity of 763 mAh/g, large peak power density of 270 mW/cm2, and robust stability. Ultraviolet photoelectron spectroscopy and theoretical simulation confirmed that the alloying of Ni into Fe could manipulate the electronic structure and lower the reaction barriers of intermediates during the electrocatalytic ORR/OER processes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Elina Berntsson, Faraz Vosough, Teodor Svantesson, Jonathan Pansieri, Igor A. Iashchishyn, Lucija Ostojic, Xiaolin Dong, Suman Paul, Juri Jarvet, Per M. Roos, Andreas Barth, Ludmilla A. Morozova-Roche, Astrid Graslund, Sebastian K. T. S. Warmlander
Summary: Alzheimer's disease is the most common cause of dementia worldwide. It is characterized by the presence of insoluble amyloid plaques in the brain, mainly composed of aggregated amyloid-beta (A beta) peptides. Metal homeostasis is altered in AD, and elevated levels of metals such as Cu, Fe, and Zn have been observed in AD plaques. However, the role of metal ions, such as Ni(II), in AD pathology remains unclear.
SCIENTIFIC REPORTS
(2023)
Correction
Chemistry, Physical
Yuwen Wang, Xue Zhao, Jianbing Chen, Shuxing Zhou, Xianxi Zhang, Xinzhong Wang, Thomas Wagberg, Guangzhi Hu
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Correction
Green & Sustainable Science & Technology
Yingnan He, Jianbing Chen, Jiapei Lv, Yimin Huang, Shuxing Zhou, Wenyan Li, Yongtao Li, Fengqin Chang, Hucai Zhang, Thomas Wagberg, Guangzhi Hu
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Physical
Zhicheng Nie, Lei Zhang, Ziang Du, Jinsong Hu, Xinhua Huang, Chunhui Zhou, Thomas Wagberg, Guangzhi Hu
Summary: The membrane-free two-step water electrolysis, achieved through the anchoring of Co-doped Ni(OH)2 nanosheets onto a nickel foam substrate, provides a low-cost and large-scale supply of hydrogen energy. By using the Co-doping Ni(OH)2@NF electrodes as a charge mediator, the electrochemical hydrogen evolution reaction and oxygen evolution reaction are decoupled, enabling the production of H2 and O2 without a membrane. This device demonstrates promising efficiency for the conversion of renewables to hydrogen. Rating: 8 out of 10.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Ying Ye, Lei Zhang, Qiliang Zhu, Ziang Du, Thomas Wagberg, Guangzhi Hu
Summary: In this study, a novel Mott-Schottky catalytic site was successfully incorporated into an N-doping carbon nanobox, with consideration of the effects of intrinsic electric field and hollow/porous support carriers. The resulting heterogeneous catalyst exhibited promising performance for both oxygen reduction reaction and oxygen evolution reaction, leading to significant improvements in the performance of Zn-air batteries. The development of robust bifunctional oxygen catalysts through modulation of surface charge distribution and facilitation of mass transport offers a new avenue for future research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xingmei Qi, Yu Wang, Hairui Yu, Ruifang Liu, Axel Leppert, Zihan Zheng, Xueying Zhong, Zhen Jin, Han Wang, Xiaoli Li, Xiuzhe Wang, Michael Landreh, Ludmilla A. Morozova-Roche, Jan Johansson, Sidong Xiong, Igor Iashchishyn, Gefei Chen
Summary: Amyloid fibrils, which are highly ordered nanoscale aggregates, play a role in some incurable human diseases but also have physiological functions in nature. This study shows that spider silk proteins (spidroins) and the pathogenic amyloid-β peptide (Aβ) share amyloid-like properties but have different fibrillization pathways. Aβ forms amyloid nanofibrils through nucleation-dependent polymerization, while spidroins spontaneously and rapidly form amyloid-like nanofibrils through non-nucleation-dependent lateral packing. Spidroin nanofibrils lack cytotoxicity and do not self-seed or cross-seed human amyloidogenic peptides, suggesting that they have evolved unique primary structures to avoid the formation of cytotoxic intermediates.
Article
Endocrinology & Metabolism
Johan Svensson, Klara Sjogren, Lina Lawenius, Antti Koskela, Juha Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Summary: Insulin-like growth factor-I (IGF-I) levels and cortical bone dimensions play important roles in determining fracture risk in elderly people. Inactivation of liver-derived circulating IGF-I reduces periosteal bone expansion in young and older mice. This study investigates the effect of inducible inactivation of IGF-I specifically in bone on the bone phenotype in adult/old mice, finding that it results in reduced radial growth of cortical bone, suggesting the importance of locally derived IGF-I in regulating the cortical bone phenotype in older mice.
