期刊
CHEMISTRY OF MATERIALS
卷 26, 期 24, 页码 7166-7171出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm503831t
关键词
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资金
- KAIST HRHRP [N10130008]
- Midcareer Researcher Program through the National Research Foundation (NRF) - MSIP [2014R1A2A2A01005813]
- Industrial strategic technology development program of the Korea Evaluation Institute of Industrial Technology (KEIT) - MOTIE [10045068]
Semipermeable microcapsules have a great potential in controlled release of drugs, protection of catalysts, and immunoisolation of cells. However, a method to create such microcapsules with precisely controlled cutoff value and high mechanical stability remains an important challenge. Herein we report microfluidic approach to create microcapsules with size-selective permeability using phase separation of polymer blends in ultrathin middle layer of double-emulsion drops. The blend strongly confined in two-dimensional space exhibit local phase separation, instead of global separation. This enables the perforation of microcapsule membrane by selectively removing one of the phase-separated polymeric domains. The resultant monolithic membrane has uniform pores which connect the interior and the exterior of the microcapsules, thereby providing size-selective permeability. The pore size can be precisely tuned by regulating the extent of phase separation; this enables the control of cutoff value for permeation.
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