期刊
CHEMISTRY OF MATERIALS
卷 23, 期 21, 页码 4701-4708出版社
AMER CHEMICAL SOC
DOI: 10.1021/cm201211n
关键词
liposome; polysaccharide; DNA; calcium phosphate; nanocapsule; layer-by-layer deposition; organic-inorganic hybrid
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [22-5326]
- Grants-in-Aid for Scientific Research [10J05326] Funding Source: KAKEN
We created an organic-inorganic hybrid nanocapsule by utilizing polysaccharide-coated liposomes as a reaction site for the deposition of calcium phosphate (CaP). Phosphate ions were encapsulated in a liposome, followed by the layer-by-layer deposition of chitosan (CHI), dextran sulfate (DXS), or DNA onto the liposome surface. Calcium ions were added to an aqueous suspension of the phosphate ion-incorporated nanocapsules to prepare the nanocapsules that provide a variety of walls for the counter-diffusion of ions and the surface for CaP deposition. As a result, control in biomineralization, such as thickness and crystal properties, over the nanocapsules was achieved by tuning the counter-diffusion of the calcium ions and the phosphate ions through the capsule wall and the surface chemical composition of nanocapsules. Furthermore, we carried out DNA adsorption onto CaP-coated liposomes. DNA was releasable from the nanocapsules because of the dissolution of CaP under acidic conditions.
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