Article
Materials Science, Biomaterials
Nahida Rasool, Deepa Negi, Yashveer Singh
Summary: Osteoporosis is a chronic bone disorder characterized by decreased bone mass and increased fracture risk. This study developed thiolated, bioactive mesoporous silica nanoparticles (MSN-SH) with antioxidant and regenerative properties for potential treatment of osteoporosis. MSN-SH exhibited high antioxidant activity, protected cells from reactive oxygen species-induced damage, and induced osteogenesis. It also inhibited osteoclastogenesis, promoted migration of osteoblast cells, and showed potential as a complementary treatment for osteoporosis. The surface modification of MSN-SH offers a simple and economical method to enhance its properties and introduce new activities.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Andrii Fedorchuk, Alain Walcarius, Magdalena Laskowska, Neus Vila, Pawel Kowalczyk, Krzysztof Cpalka, Lukasz Laskowski
Summary: A chemical procedure was developed to prepare highly ordered and vertically aligned mesoporous silica films containing selected contents of silver ions. The functionalization level can be finely tuned by controlling the co-condensation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Shusei Tanizume, Sota Maehara, Katsunori Ishii, Takamasa Onoki, Takuya Okuno, Hiromasa Tawarayama, Shinji Ishikawa, Mikihiro Nomura
Summary: By synthesizing a defect-free MFI zeolite membrane on a porous silica substrate, high selectivity and yield of olefins from methanol conversion can be achieved.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Eunji Ji, Kyungmin Yang, June-Chul Shin, Youngbum Kim, Jin-Woo Park, Jeongyong Kim, Gwan-Hyoung Lee
Summary: The optical and electrical properties of monolayer molybdenum disulfide are strongly influenced by the functionalized substrate, which provides insights into the variations in material properties observed on different substrates in previous studies.
Article
Immunology
Ivana Skakic, Jasmine E. Francis, Chaitali Dekiwadia, Ibukun Aibinu, Mohsina Huq, Aya C. Taki, Anna Walduck, Peter M. Smooker
Summary: Protein nanocapsules containing the A subunit of Helicobacter pylori urease were synthesized using removable silica templates. The nanocapsules of different sizes were evaluated as vaccines in a mouse model and showed protective efficacy against H. pylori infection.
Article
Chemistry, Analytical
Yuan Yuan, Yuhan He, Dongni Pei, Liujuan Tong, Shengqiang Hu, Lin Liu, Xinyao Yi, Jianxiu Wang
Summary: Urease-functionalized near-infrared (NIR) light-responsive gold nanoflowers (AuNFs) were used as a sensing platform for urea assay. By changing the temperature and activity of the urease-AuNFs composites, the concentration of urea could be rapidly detected. This method conveniently measured urea in blood samples within 10 minutes, and the results were in good agreement with clinical results.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Johannes Strobl, Fanny Kozak, Meder Kamalov, Daniela Reichinger, Dennis Kurzbach, Christian F. W. Becker
Summary: The article discusses the limitations of mimicking biological materials and introduces a peptide library that enables the design of biomimetic materials. It explains that the formation of biomaterials is governed by self-assembling precursors, and these precursors can be manipulated to control the morphology of silica particles. The study uses residue-resolved real-time NMR spectroscopy and molecular dynamics simulations to understand the atomistic details of the templates.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Simon Greiner, Jan Hettig, Alec Laws, Katharina Baumgaertner, Jenna Bustos, Ann-Christin Poeppler, Adam H. Clark, May Nyman, Carsten Streb, Montaha Anjass
Summary: In this paper, we report a universal precursor that can be used to synthesize metal-functionalized polyoxovanadate clusters. The precursor is synthesized through a novel solid-state thermal treatment method. By reacting the precursor with various metal nitrate salts, a range of metal-functionalized POVs can be obtained, providing new components for molecular magnetism, energy technologies, or catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Coatings & Films
Dandan Li, Han Peng, Zaiwen Lin, Jiahui Zhu, Jing Yu, Jingyuan Liu, Rongrong Chen, Qi Liu, Jun Wang
Summary: Silane-functionalized rGO/SiO2 nanocontainers with excellent dispersibility and load capacity were successfully synthesized, leading to composite corrosion protection coatings with improved permeability resistance and self-repairing performance. The coatings exhibited good dispersion stability, surface wettability, and enhanced corrosion resistance.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Yufeng Shen, Huiliang Geng, Feifang Zhang, Zongying Li, Bingcheng Yang
Summary: A polyethyleneimine-functionalized polymer substrate polar stationary phase was prepared for hydrophilic interaction chromatography (HILIC) by grafting PEI onto PS-DVB microspheres. The phase exhibited a U-shape retention profile and typical hydrophilic characteristics when the organic solvent fraction in the mobile phase was above 60%. The retention mechanism involved hydrogen bonding, anion exchange, and hydrophobic interaction, and good separation and unique selectivity for acidic, basic, and neutral polar analytes were achieved. The phase showed extremely low column bleed, comparable to that of the blank, under gradient elution mode and had a wide pH tolerance range of at least 1-13.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Applied
Edith Mawunya Kutorglo, Frantisek Muzika, Fatima Hassouna, Giuseppe Storti, Dusan Kopecky, Roman Bleha, Andriy Synytsya, Ivona Sedlarova, Miroslav Soos
Summary: Immobilizing enzymes on 3D porous materials can enhance stability and reusability, and the 3D porous materials synthesized using a template method with chemically accessible surfaces show potential as biocatalyst supports.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Gea Prioglio, Silvia Agnelli, Stefano Pandini, Maurizio Galimberti
Summary: Silica-based rubber composites are important for reducing hysteresis in dynamic-mechanical applications, but face drawbacks such as poor rheological behavior. This work developed an innovative hybrid filler system using nanosized high surface area graphite and silica, resulting in a rubber composite with improved properties. The best composite properties were achieved with the addition of HSAG-SP, which showed similar dynamic rigidity and hysteresis as silica-based materials, but better rheological properties.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Yangyang Ye, Runqiu Lu, Hao Ren, Yang Yang, Tianqi Li, Xiangyu Zhang, Peng Yang, Xu Zhang
Summary: A biomimetic approach was used to construct a biomimetic microenvironment for enamel remineralization. By pH regulation, enamel-like crystals with proper structure and mechanical properties were regenerated. The study revealed the crucial role of enamel matrix proteins in enamel formation and provided a promising biomimetic strategy for enamel repair.
MATERIALS & DESIGN
(2023)
Article
Multidisciplinary Sciences
Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James
Summary: Attachment of ubiquitin to proteins is a versatile and abundant posttranslational modification that affects outcomes in various physiological processes. Substrate binding can induce a specific RING topology that enables self-ubiquitination. Studies have provided insights into the chemical mechanism of ubiquitin conjugation and the formation of ubiquitin chains.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Nora Igaz, Peter Belteky, David Kovacs, Csaba Papp, Andrea Ronavari, Diana Szabo, Attila Gacser, Zoltan Konya, Monika Kiricsi
Summary: The efficient delivery of Rhodamine 123 and Mitomycin C to multidrug-resistant cells via mesoporous silica nanoparticles (MSNs), resulting in increased intracellular drug concentration and enhanced cytotoxic effects, demonstrates the enormous potential of MSNs in overcoming multidrug-resistant cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Huan Zhang, Xuejun Lu, Laura Gonzalez-Aguilera, M. Luisa Ferrer, Francisco del Monte, Maria C. Gutierrez
Summary: Deep eutectic solvents and their dilutions, particularly in aqueous solutions, exhibit deviations from ideality in terms of density and viscosity. The use of a mixture or pseudo-component model can impact the characterization of these deviations, with different molecular weight models showing some differences in the absolute magnitude of the deviation and the content at which the minimum appears. Additionally, the formation of hydrogen bonding networks in aqueous dilutions suggests a more appropriate treatment of the deep eutectic solvent as a pseudo-component.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Huan Zhang, M. Luisa Ferrer, Rafael J. Jimenez-Rioboo, Francisco del Monte, Maria C. Gutierrez
Summary: Deep eutectic solvents (DES) and their dilutions are gaining interest in sustainable processes, with dilutions showing superior performance in certain applications. The extension of the dilution range in the solvent-DES regime is influenced by the solubility of DES components in different solvents and the strength and/or number of hydrogen bonds between DES components and solvent molecules.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Cell & Tissue Engineering
Joe P. Woodley, Daniel W. Lambert, Ilida Ortega Asencio
Summary: Fibroblasts exhibit diverse behaviors in different culture systems and their response to biomimetic materials is influenced by a complex interplay of biological features, material properties, and microarchitectural features. Understanding the influence of biomaterials on fibroblast behavior is challenging due to the heterogeneous nature of fibroblasts and their tissue-specific phenotypic traits. Despite these challenges, investigating fibroblast behavior in 3D culture using a range of materials can provide insights into potential therapeutic opportunities for diseases such as cancer and fibrosis.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Betul Aldemir Dikici, Atra Malayeri, Colin Sherborne, Serkan Dikici, Thomas Paterson, Lindsey Dew, Paul Hatton, Ilida Ortega Asencio, Sheila MacNeil, Caitlin Langford, Neil R. Cameron, Frederik Claeyssens
Summary: Highly porous emulsion templated polymers (PolyHIPEs) offer advantages in tissue engineering and regenerative medicine scaffolds by providing porosity for cell ingrowth and nutrient diffusion. This study demonstrates the fabrication of biodegradable PolyHIPE materials using thiol-ene chemistry, and shows their biocompatibility and ability to support cell attachment and viability.
Article
Biochemistry & Molecular Biology
Huan Zhang, Andreea Ionita, Pilar F. Serinan, Maria Luisa Ferrer, Maria A. Rodriguez, Aitana Tamayo, Fausto Rubio Alons, Francisco del Monte, Maria C. Gutierrez
Summary: Ionic liquids and deep eutectic solvents are widely used neoteric solvents. By adding acetic acid to 1-Ethyl-3-methylimidazolium chloride, the transition from the original ionic liquid to a eutectic mixture of EMIMCl and AcOH can be promoted. The study investigated the effects of this transition on cellulose regeneration and EMIMCl recovery, and demonstrated the potential application for obtaining highly acetylated cellulose.
Article
Chemistry, Multidisciplinary
Huan Zhang, Jose Manuel Vicent-Luna, Shuxia Tao, Sofia Calero, Rafael J. Jimenez Rioboo, Maria Luisa Ferrer, Francisco del Monte, Maria Concepcion Gutierrez
Summary: Ionic liquids (ILs) and deep eutectic solvents (DESs) have emerged as alternatives to conventional solvents, and despite their different interaction types, they can be considered as two sides of the same coin. In this study, a transition from 1-ethyl-3-methylimidazolium chloride (EMIMCl) to EMIMCl·nAcOH-based DESs was promoted by adding stoichiometric amounts of acetic acid (AcOH) to EMIMCl. The transition was confirmed through various spectroscopic and simulation techniques. The resulting DESs exhibited different solvent properties, and the aqueous dilutions deviated from ideality due to the formation of hydrogen bonds between water molecules and the anion.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Emilia Barker, Joanna Shepherd, Ilida Ortega Asencio
Summary: Cerium and its derivatives have a long history of being used in wound treatment, particularly in the treatment of deep burns. Despite some conflicting data, cerium compounds are still believed to have antimicrobial properties, especially against Pseudomonas aeruginosa. Nanoceria, in nanoparticle form, has gained attention for its antibacterial properties, but bacterial resistance to these nanoparticles is a growing concern.
Article
Biotechnology & Applied Microbiology
Joe P. Woodley, Daniel W. Lambert, Ilida Ortega Asencio
Summary: In vivo, quiescent fibroblasts in connective tissues are activated in response to injury and become migratory and contractile myofibroblasts. Chronic activation leads to fibrotic disease. Fibroblasts cultured on 2D surfaces show partial activation, while many 3D environments limit activation. Controlled by material properties and micro-architecture, cell mechanotransduction, spreading, polarity, and integrin expression vary between 3D culture systems.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Tian, Thomas E. Paterson, Jingjia Zhang, Yingxing Li, Han Ouyang, Ilida Ortega Asencio, Paul V. Hatton, Yu Zhao, Zhou Li
Summary: The infection of implanted biomaterial scaffolds is a challenging issue, and traditional treatment methods are becoming less practical. In this study, a novel PCL scaffold functionalized with ZnO nanowires was developed and characterized. The results showed that the ZnO nanowires were successfully incorporated into the scaffold, and it exhibited excellent antibacterial properties and biocompatibility, making it a promising choice for implanted scaffolds in tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Anne Beaucamp, Muhammad Muddasar, Ibrahim Saana Amiinu, Marina Moraes Leite, Mario Culebras, Kenneth Latha, Maria C. Gutierrez, Daily Rodriguez-Padron, Francisco del Monte, Tadhg Kennedy, Kevin M. Ryan, Rafael Luque, Maria-Magdalena Titirici, Maurice N. Collins
Summary: Lignin, a by-product of papermaking and biofuel industries, is a valuable sustainable polymer suitable for high value energy applications. This review discusses lignin chemistry, extraction techniques, and important chemistries for emerging energy applications.
Article
Chemistry, Physical
Huan Zhang, Laura Gonzalez-Aguilera, Daniel Lopez, M. Luisa Ferrer, Francisco del Monte, Maria C. Gutierrez
Summary: NMMO is the preferred solvent in the lyocell process due to its interesting biodegradable, non-toxic, and non-ecotoxic features. Addition of co-solvents helps balance the NMMO-cellulose-HBs and H2O-cellulose-HBs, modifying the solvent capabilities of the resulting ternary mixture.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biotechnology & Applied Microbiology
David H. Ramos-Rodriguez, Samand Pashneh-Tala, Amanpreet Kaur Bains, Robert D. Moorehead, Nikolaos Kassos, Adrian L. Kelly, Thomas E. Paterson, C. Amnael Orozco-Diaz, Andrew A. Gill, Ilida Ortega Asencio
Summary: This research explores the suitability of using a new sustainable polyester blend as a scaffold for musculoskeletal applications. The blend shows biocompatibility and improvement in osteogenic activity, making it promising for bone tissue regeneration.
BIOENGINEERING-BASEL
(2022)
