Article
Chemistry, Organic
Zhao-Lin He, Wen Tian, Gang Wang
Summary: A novel oxidative (3 + 3) cycloaddition/ring-opening reaction has been developed between N,N'-cyclic azomethine imines and in situ generated diaza-oxylallyl cations from simple urea derivatives in the presence of base and PhI(OAc)(2). This transformation shows good performance with a broad substrate scope, providing easy and rapid access to 1,2,3,5-tetrazine-4(1H)-one derivatives in good yields.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Arthur Lebrene, Thomas Martzel, Laura Gouriou, Morgane Sanselme, Vincent Levacher, Sylvain Oudeyer, Carlos Afonso, Corinne Loutelier-Bourhis, Jean-Francois Briere
Summary: A straightforward method for synthesizing original 1,6-diazabicyclo[4.3.0]nonane-2,7-diones was developed using a DBU-organocatalyzed multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction. Analysis of key reactive intermediates using mass spectrometry confirmed the proposed mechanism.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Guangjun Bao, Peng Wang, Guofeng Li, Changjun Yu, Yiping Li, Yuyang Liu, Zeyuan He, Tiantian Zhao, Jing Rao, Junqiu Xie, Liang Hong, Wangsheng Sun, Rui Wang
Summary: A new method for 1,3-dipolar cycloaddition reactions between different types of amino acids to generate various quaternary amino acids was disclosed in this study. This method can also be applied within peptide chains, providing a new approach for late-stage peptide modification and drug conjugation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Guipeng Feng, Guoyang Ma, Wenyan Chen, Shaohong Xu, Kaikai Wang, Shaoyan Wang
Summary: The [3 + 2] 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with allyl alkyl ketones has been achieved, resulting in a range of tetrahydroisoquinoline derivatives with good diastereoselectivities and enantioselectivities. The absolute configuration of the product was determined using quantum electronic circular dichroism calculation and ECD spectrum method.
Article
Chemistry, Organic
Jian-Bin Lu, Shu-Yuan Liang, Wu-Tao Gui, Zhi-Chao Chen, Wei Du, Ying-Chun Chen
Summary: A relay catalytic protocol utilizing pyrrolidine and palladium catalysis has been developed for the asymmetric synthesis of 1,3-diamine derivatives from 3-substituted 1,3-dienes, sulfuric diamide, and aldehydes. This one-pot, three-component reaction offers the advantages of high atom step economy and operational simplicity, providing an efficient and straightforward access to valuable 1,3-diamines containing quaternary and tertiary stereogenic centers with moderate to good enantioselectivity.
Article
Chemistry, Multidisciplinary
Madavi S. Prasad, Sankar Bharani, Syed Mastan Sharief, Mudavath Ravi, Murugesan Sivaprakash, Biplob Borah, L. Raju Chowhan
Summary: The application of 2-aryl/heteroarylidene-1H-indene-1,3(2H)-dione as an activated olefin source in the DABCO-catalyzed [3 + 2] cycloaddition with N-2,2,2-trifluoroethylisatin ketimines has been disclosed. This highly efficient 1,3-dipolar cycloaddition reaction offers a variety of trifluoromethyl group bearing spiro-pyrrolidine linked oxindoles with four consecutive stereocentres in good to excellent yield and excellent diastereoselectivity.
Article
Biochemistry & Molecular Biology
Yongchao Wang, Lijun Yan, Yuxin Yan, Sujin Li, Hongying Lu, Jia Liu, Jianwei Dong
Summary: In this study, a sustainable, catalysis-free, and dipolarophile-controlled three-component 1,3-dipolar cycloaddition reaction was used to synthesize 40 functionalized N-fused pyrrolidinyl spirooxindoles with excellent diastereoselectivities. The scaffolds of these compounds can be controlled by using different 1,4-enedione derivatives as dipolarophiles in EtOH at room temperature. This study provides an efficient strategy for the synthesis of natural-like and potentially bioactive N-fused pyrrolidinyl spirooxindoles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Bo-Jyun Wun, Yung-Chen Hu, Chu-Yun Chi, Gary Jing Chuang
Summary: We report a photoinduced decarbonylative rearrangement for the synthesis of a unique functionalized diazabicyclo[4.1.0]heptene skeleton, which is a derivative of the hydropyridazine structure that is found in various biologically active natural products. The compatibility of functional groups in the photoreaction was explored using the heterobicyclo[2.2.2] structure obtained from the Diels-Alder reaction of masked o-benzoquinones. 4-Phenyl-1,2,4-triazoline-3,5-dione served as the dienophile, providing the adjacent N-N unit in the hexahydropyridazine-type products of the subsequent photorearrangement.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Jianfeng Zheng, Lin Yang, Xin Dai, Lvli Chen, Luhao Tang, Yuqiao Zhou, Wei-Dong Z. Li
Summary: Magnesium-(II)-catalyzed cascade reactions of N,N'-cyclic azomethine imines with indolyl-substituted isocyanides were conducted. The method showed high tolerance towards different functional groups and had a wide range of substrates. A series of anti-pentacyclic spiroindolines with N,N'-fused heterocycle skeletons were obtained in good yields (up to 82%) with high selectivity (8.5:1 dr) under mild conditions. Interestingly, a sequential HOAc-mediated protonation led to diastereoenriched epimerization, resulting in the formation of exclusively syn-pentacyclic spiroindolines.
Article
Chemistry, Multidisciplinary
Zhenni Zhao, Zhi Ou, Subarna Jyoti Kalita, Feng Cheng, Qian Huang, Yangyi Gu, Yuhao Wang, Yan Zhao, Yiyong Huang
Summary: This paper reports the first example of a stereoconvergent reaction involving 1,3-dipolar cycloaddition of nitrile oxides and nitrile imines with electron-deficient olefins. The reaction produces compounds with multiple stereogenic centers and exhibits excellent regio- and diastereoselectivities. Through control experiments and calculations, the possibility of thermodynamically stable diastereomers formation during the reaction is ruled out, and a stepwise mechanism is proposed.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Organic
Dennis Svatunek, Thomas Hansen, Kendall N. Houk, Trevor A. Hamlin
Summary: The Lewis base F- catalyzes the 1,3-dipolar cycloaddition between CO2 and nitrilimines by activating the nitrilimine and enhancing the rate of the reaction. The strength of primary orbital interactions between the reactants is the origin of this catalysis. The Lewis base activated nitrilimine-F- has high-lying filled FMOs, which promote a rapid nucleophilic attack and overall cycloaddition with CO2.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sha Li, Yahan Sun, Xiaofang Li, Oskar Smaga, Sebastian Koniarz, Marcin Stepien, Piotr J. Chmielewski
Summary: A 1,3-cycloaddition reaction between 2-(tert-butyl)-8H-isoquinolino[4,3,2-de]phenanthridin-9-ium chloride and Ni-II norcorrole in the presence of base has been demonstrated to yield a family of chiral derivatives fused with pyrrole subunits of the macrocycle. Dehydrogenation of the cycloaddition products leads to dibenzoullazine ortho-fused antiaromatic porphyrinoids.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Popuri Sureshbabu, Vinod Bhajammanavar, Venkata Surya Kumar Choutipalli, Venkatesan Subramanian, Mahiuddin Baidya
Summary: An unconventional cascade annulation of arynes with N-alkyl-N-nitrosamides has been developed, providing functionalized indazoles in high yields and regioselectivity under transition-metal-free conditions at ambient temperature. The protocol is scalable and exhibits a broad substrate scope, and the reaction mechanism has been studied with DFT calculations.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Keita Tanaka, Martin-Louis Y. Riu, Brian Valladares, Christopher C. Cummins
Summary: In this study, a new class of Azophosphines and N-heterocyclic iminophosphoranes (NHIPs) were successfully synthesized. The NHIPs exhibited tunability of steric demands and good basicity. The facile and scalable synthesis of NHIPs suggests their potential applications in synthetic chemistry.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Keita Tanaka, Martin-Louis Y. Riu, Brian Valladares, Christopher C. Cummins
Summary: This study presents the preparation and cycloaddition reactions of Azophosphines. The results show that these compounds have good adaptability to phosphorus atom substituents and can generate structures similar to cyclic (alkyl)(amino)carbenes. The NHIPs exhibit strong sigma-donor strengths and basicity, and display unique reactivity in certain reactions. The tunability of steric demands and scalability of these compounds suggest that they may have a wide range of applications in synthetic chemistry.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
A. I. Ukolov, T. I. Orlova, E. I. Savel'eva, A. S. Radilov
JOURNAL OF ANALYTICAL CHEMISTRY
(2015)
Review
Biochemistry & Molecular Biology
N. V. Goncharov, D. A. Belinskaya, A. V. Razygraev, A. I. Ukolov
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2015)
Article
Chemistry, Organic
Yu. B. Koptelov, D. O. Antuganov, A. P. Molchanov, R. R. Kostikov
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Chemistry, Organic
Yu. B. Koptelov, A. P. Molchanov, R. R. Kostikov
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Chemistry, Analytical
I. G. Zenkevich, A. I. Ukolov, A. S. Kushakova, L. K. Gustyleva
JOURNAL OF ANALYTICAL CHEMISTRY
(2011)
Article
Chemistry, Analytical
I. G. Zenkevich, E. V. Eliseenkov, A. N. Kasatochkin, A. I. Ukolov
JOURNAL OF ANALYTICAL CHEMISTRY
(2011)
Article
Chemistry, Analytical
A. I. Ukolov, I. G. Zenkevich
JOURNAL OF ANALYTICAL CHEMISTRY
(2012)
Article
Chemistry, Analytical
A. I. Ukolov, I. G. Zenkevich
JOURNAL OF ANALYTICAL CHEMISTRY
(2014)
Article
Biochemical Research Methods
Tatiana A. Kornilova, Anton I. Ukolov, Rafael R. Kostikov, Igor G. Zenkevich
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2013)
Article
Chemistry, Multidisciplinary
I. G. Zenkevich, A. I. Ukolov
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2011)
Article
Chemistry, Multidisciplinary
T. A. Kornilova, A. I. Ukolov, R. R. Kostikov, I. G. Zenkevich
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2012)
Article
Chemistry, Organic
Yu. B. Koptelov, S. P. Saik, A. P. Molchanov, S. I. Selivanov
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2011)
Article
Chemistry, Organic
Yu. B. Koptelov, S. P. Saik, A. P. Molchanov
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2011)
Article
Chemistry, Organic
Yu. B. Koptelov, M. V. Sednev, R. R. Kostikov
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Chemistry, Medicinal
Victoria Abzianidze, Natalia Moiseeva, Diana Suponina, Sofya Zakharenkova, Nadezhda Rogovskaya, Lidia Laletina, Alvin A. Holder, Denis Krivorotov, Alexander Bogachenkov, Alexander Garabadzhiu, Anton Ukolov, Vyacheslav Kosorukov
Summary: In this study, natural phaeosphaeride A (PPA) derivatives were synthesized and tested for their antitumor efficacy on different tumor cell lines. The results showed that all the synthesized compounds had better efficacy than PPA. Among them, three compounds were able to overcome the drug resistance of tumor cells by modulating the activity of P-glycoprotein. Luminex xMAP technology and xCelligence RTCA equipment were used to assess the effects of the compounds on intracellular signaling pathways and cell culture.