☆ 4.3 Article

Isolation and Structure of a Novel Biindole Pigment Substituted with an Ethyl Group from a Metagenomic Library Derived from the Marine Sponge Halichondria okadai

CHEMISTRY LETTERS (2012)

期刊

CHEMISTRY LETTERS

卷 41, 期 7, 页码 728-729

出版社

CHEMICAL SOC JAPAN

DOI: 10.1246/cl.2012.728

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Chemistry, Multidisciplinary

资金

[16GS0206]
[21221009]
Grants-in-Aid for Scientific Research [21221009] Funding Source: KAKEN

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摘要

We screened a colored clone from a metagenomic library derived from the marine sponge Halichondria okadai. We isolated a yellow pigment, halichrome A (1), which was structurally elucidated to be a biindole, exhibited cytotoxicity against B16 melanoma cells and was substituted with an ethyl group. To the best of our knowledge, this is the first report of the isolation of a novel compound from a metagenomic library derived from a marine sponge.

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