Preparation of Nanoaggregates through Self-assembly of Amphiphilic Polyrotaxane Composed of PLLA-PEG-PLLA Triblock Copolymer and α-Cyclodextrins

An amphiphilic polyrotaxane (PRX) composed of biodegradable triblock copolymer of poly(ethylene glycol) (PEG) and poly(L-lactide) (PLLA), PLLA PEG PLLA, and many alpha-cyclodextrins (alpha-CD) threaded on the triblock copolymer was successfully synthesized. The PRX was found to be self-assembled into vesicle-like water-soluble nanoaggregates in an aqueous solution.