期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 165, 期 2, 页码 238-243出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2012.01.002
关键词
Corneocyte; Cosmetic; X-ray diffraction; Intercellular lipid; Pharmaceutics; Regulation; Soft keratin; Stabilization; Water
资金
- Ministry of Education, Culture, Sports, Science and Technology [18540411, 19790805]
- Grants-in-Aid for Scientific Research [19790805, 18540411] Funding Source: KAKEN
We studied the water regulation mechanism in human stratum corneum which is composed of corneocytes and intercellular lipid matrix by the ex vivo small- and medium-angle X-ray diffraction. Under the normal condition water molecules are stored mainly in the corneocytes. When the water content increased, from the small-angle X-ray diffraction of the human stratum corneum we obtained the swelling behavior of the short lamellar lipid structure as a result of incorporating a very small amount of water into water layers between neighboring the lipid bilayers. and its diffraction peak width became narrow and turned to wide at the water content of 20-30 wt%. In addition as evidence for uptake of water in the corneocytes, we observed the structural modification of soft keratins in the corneocytes from the medium-angle X-ray diffraction. Based upon these results we propose that the water content in the human stratum corneum is regulated to be at 20-30 wt% so as to stabilize the short lamellar structure in the intercellular lipid matrix. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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