Article
Biochemistry & Molecular Biology
L. Nunez-Magos, J. Lira-Escobedo, R. Rodriguez-Lopez, M. Munoz-Navia, F. Castillo-Rivera, P. X. Viveros-Mendez, E. Araujo, A. Encinas, S. A. Saucedo-Anaya, S. Aranda-Espinoza
Summary: The potential applications of magnetic nanoparticles in biomedicine have been studied, with challenges in size, biocompatibility, stabilization, and surface coating. Magnetoliposomes are used to reduce toxicity and deliver drugs. When exposed to a DC magnetic field, the encapsulated superparamagnetic nanoparticles form chains, dispersing when the field is switched off, while floppy liposomes deform along the magnetic field direction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jordan Trilli, Laura Caramazza, Patrizia Paolicelli, Maria Antonietta Casadei, Micaela Liberti, Francesca Apollonio, Stefania Petralito
Summary: The study focused on the potential role of magnetoliposomes in biomedical applications, particularly investigating the impact of bilayer packaging on compound release. The results demonstrated the efficacy of the magnetic trigger on high-ordered bilayers for efficient compound release.
Article
Biochemistry & Molecular Biology
Andrey Anosov, Oksana Koplak, Elena Smirnova, Elizaveta Borisova, Eugenia Korepanova, Alice Derunets
Summary: This study investigates the conductivity of diphytanoylphosphatidylcholine bilayer lipid membranes induced by interaction with cubic magnetic nanoparticles (MNPs) of cobalt ferrite with different sizes coated with a hydrophilic shell. The results show that the interaction of MNPs with the lipid bilayer leads to the formation of metastable conductive pores and increases the membrane's integral conductance. The effect of MNP concentration on conductance is independent of particle size.
Article
Biochemistry & Molecular Biology
Fabio A. C. Lopes, Andre V. F. Fernandes, Juliana M. Rodrigues, Maria-Joao R. P. Queiroz, Bernardo G. Almeida, Ana Pires, Andre M. Pereira, Joao P. Araujo, Elisabete M. S. Castanheira, Ana Rita O. Rodrigues, Paulo J. G. Coutinho
Summary: The study involved the preparation of multicore magnetic nanoparticles and magnetoliposomes, showing potential for cancer treatment, especially in combined magnetic hyperthermia and chemotherapy.
Article
Pharmacology & Pharmacy
Beatriz D. Cardoso, Ana Rita O. Rodrigues, Manuel Banobre-Lopez, Bernardo G. Almeida, Carlos O. Amorim, Vitor S. Amaral, Paulo J. G. Coutinho, Elisabete M. S. Castanheira
Summary: The study introduces a novel lipid nanocarrier with superparamagnetic properties for precise drug release through magnetic guidance and control. Optimized manufacturing techniques result in the production of nano-systems with suitable sizes for biomedical applications and high encapsulation efficiency, exhibiting superior drug release kinetics under hyperthermia temperatures and acidic conditions.
Article
Biochemistry & Molecular Biology
Edyta Maron, Pawel Krysinski, Michal Chudy
Summary: The article introduces magnetoliposomes as potential carriers of doxorubicin. The magnetic properties of nanoparticles embedded in liposomes enable targeted drug delivery to cancer cells and subsequent release using an external magnetic field. The cytotoxicity of empty and doxorubicin-loaded magnetoliposomes was evaluated in cancerous and normal breast cells. The study shows that magnetoliposomes with doxorubicin exhibit high cytotoxicity on tumor cells and low cytotoxicity on normal cells, indicating their potential application in drug release in cancer cells under the influence of a magnetic field.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Alexandra Schroter, Carla Arnau del Valle, Maria J. Marin, Thomas Hirsch
Summary: This research introduces a bilayer-based strategy for surface modification of hydrophobic nanoparticles, allowing for excellent colloidal stability in aqueous environments and protection against disintegration while permitting surface functionalization. The potential of this strategy was demonstrated using upconversion nanoparticles. This surface engineering strategy is important for protecting and functionalizing inorganic nanoparticles in biological media for theranostic applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Oksana Petrichenko, Aiva Plotniece, Karlis Pajuste, Martins Rucins, Pavels Dimitrijevs, Arkadij Sobolev, Einars Sprugis, Andrejs Cebers
Summary: The study focused on evaluating the impact of different substitutions and substitution positions on the physicochemical properties of 1,4-DHP molecules and the formation of magnetoliposomes. The results showed that alkyl chain length affects the thermal behavior of 1,4-DHP molecules, but variations in substitution positions had minimal influence on liposome properties.
Review
Pharmacology & Pharmacy
Sergio R. S. Veloso, Raquel G. D. Andrade, Elisabete M. S. Castanheira
Summary: Magnetoliposomes have gained attention as delivery systems for on-demand drug release and real-time monitoring of therapy. Various structures have been reported to ensure efficient drug transport and delivery, while improving magnetic properties. However, there is a lack of assessment on formulations and complementary techniques for optimizing thermotherapy efficiency in current literature.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Stefan Nitica, Ionel Fizesan, Roxana Dudric, Felicia Loghin, Constantin Mihai Lucaciu, Cristian Iacovita
Summary: This paper presents a simple method for preparing thermosensitive magnetoliposomes loaded with doxorubicin. The liposomes showed no toxicity against cancer cells at low concentrations, but when the drug was released and the cells were exposed to a magnetic field, their viability significantly decreased.
Article
Biochemistry & Molecular Biology
Francesca Oltolina, Maria del Carmen Santaella Escolano, Ylenia Jabalera, Maria Prat, Concepcion Jimenez Lopez
Summary: This study demonstrates the concept of a promising drug carrier for cancer therapy based on targeted magnetic liposomes, which can achieve localized chemotherapy on target cancer cells using specific antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Article
Chemistry, Multidisciplinary
Beatriz D. Cardoso, Diana E. M. Fernandes, Carlos O. Amorim, Vitor S. Amaral, Paulo J. G. Coutinho, Ana Rita O. Rodrigues, Elisabete M. S. Castanheira
Summary: This study focuses on the design, development, and characterization of magnetoliposomes (MLs) for targeted encapsulation and controlled release of antitumor drugs. It introduces a new synthesis methodology for coupling superparamagnetic nanoparticles to the lipid surface of MLs. The magnetic nanoparticles have demonstrated good potential for photothermal hyperthermia, and when coupled with lipids, they form nano-carriers for drug delivery. The results show that the MLs have a higher drug release rate in acidic environments and under NIR-laser stimulation.
Article
Pharmacology & Pharmacy
Carlos E. Torres, Javier Cifuentes, Saul C. Gomez, Valentina Quezada, Kevin A. Giraldo, Paola Ruiz Puentes, Laura Rueda-Gensini, Julian A. Serna, Carolina Munoz-Camargo, Luis H. Reyes, Johann F. Osma, Juan C. Cruz
Summary: Encapsulation of magnetite nanoparticles (MNPs) into liposomes to form magnetoliposomes (MLPs) is an effective strategy for drug delivery. In this study, a low-cost microfluidic approach was used to synthesize and purify MLPs, and their biocompatibility and functional performance were tested. The results demonstrated that MLPs had suitable size and encapsulation efficiency, as well as good biocompatibility and efficient delivery capabilities.
Article
Chemistry, Multidisciplinary
Dennis J. Michalak, Mathias Losche, David P. Hoogerheide
Summary: Interfaces between molecular organic architectures and oxidic substrates exhibit sharp, reversible transitions driven by a complex interplay of electrostatic interactions and other forces. A generalized free energy potential quantitatively describes the unbinding of bilayers from supporting substrates, providing insights into the control of membrane interactions with such substrates.
Article
Biochemistry & Molecular Biology
Raja Narayanasamy, Dandamudi Usharani, Ram Rajasekharan
Summary: This study investigated the role of ABHD16B in lipid metabolism. The overexpression of ABHD16B was found to decrease cellular triacylglycerol levels and increase phospholipid synthesis in yeast cells. Additionally, ABHD16B overexpression led to a reduction in lipid droplets and significant modifications in fatty acid composition. These findings highlight the importance of ABHD16B in lipid homeostasis and provide insights into its regulatory function in cellular lipid metabolism.
CHEMISTRY AND PHYSICS OF LIPIDS
(2024)
