期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 23, 页码 6900-6904出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502011
关键词
cooperative catalysis; enamine catalysis; enantioselectivity; schizophrenia; total synthesis
资金
- Chemistry of Life Processes
- Weisman Family Foundation
Alstonine and serpentine are pentacyclic indoloquinolizidine alkaloids (referred to as anhydronium bases) containing three contiguous stereocenters. Each possesses interesting biological activity, with alstonine being the major component of a plant-based remedy to treat psychosis and other nervous system disorders. This work describes the enantioselective total syntheses of these natural products with a cooperative hydrogen bonding/enamine-catalyzed Michael addition as the key step.
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