piRNA involvement in genome stability and human cancer

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

(2014) Lan-Tao Gou et al.   CELL RESEARCH

piRNAs

(2014) Bo W. Han et al.   CURRENT BIOLOGY

piRNAs: from biogenesis to function

(2014) E.-M. Weick et al.   DEVELOPMENT

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

(2014) H Yan et al.   LEUKEMIA

Posttranscriptional Regulation of Gene Expression by Piwi Proteins and piRNAs

(2014) Toshiaki Watanabe et al.   MOLECULAR CELL

PIWI proteins and PIWI-interacting RNAs in the soma

(2014) Robert J. Ross et al.   NATURE

Mapping the miRNA interactome by cross-linking ligation and sequencing of hybrids (CLASH)

(2014) Aleksandra Helwak et al.   Nature Protocols

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

(2014) J. M. C. Tubio et al.   SCIENCE

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Novel dimensions of piRNAs in cancer

(2013) Yuping Mei et al.   CANCER LETTERS

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

(2013) Colin C. Conine et al.   CELL

Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

(2013) Ruchi Shukla et al.   CELL

L1 retrotransposons, cancer stem cells and oncogenesis

(2013) Patricia E. Carreira et al.   FEBS Journal

Retroelements in human disease

(2013) Kristel Kaer et al.   GENE

Differential L1 regulation in pluripotent stem cells of humans and apes

(2013) Maria C. N. Marchetto et al.   NATURE

PIWI-interacting RNAs: from generation to transgenerational epigenetics

(2013) Maartje J. Luteijn et al.   NATURE REVIEWS GENETICS

Rates and patterns of great ape retrotransposition

(2013) F. Hormozdiari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

(2013) Clément Monot et al.   PLoS Genetics

Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer

(2012) Long Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement

(2012) Wenwen Fang et al.   CELL

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Active human retrotransposons: variation and disease

(2012) Dustin C Hancks et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extensive somatic L1 retrotransposition in colorectal tumors

(2012) S. Solyom et al.   GENOME RESEARCH

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis

(2012) Anastassios Vourekas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection

(2011) Yi-Ming Zhao et al.   CANCER

piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

(2011) Jia Cheng et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress

(2011) Gianfranco Giorgi et al.   CELL AND TISSUE RESEARCH

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

(2011) Serena De Fazio et al.   NATURE

Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition

(2011) Elena Khazina et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical significance of Hiwi gene expression in gliomas

(2010) Guan Sun et al.   BRAIN RESEARCH

Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons

(2010) Rebecca C. Iskow et al.   CELL

Genomic gems: SINE RNAs regulate mRNA production

(2010) Steven L Ponicsan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors

(2010) Yoshifumi Baba et al.   Molecular Cancer

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

All y’all need to know ‘bout retroelements in cancer

(2010) Victoria P. Belancio et al.   SEMINARS IN CANCER BIOLOGY

Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis

(2009) Wei He et al.   BMC CANCER

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

(2009) H. Kano et al.   GENES & DEVELOPMENT

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

(2009) Sean P. Curran et al.   NATURE

The regulated retrotransposon transcriptome of mammalian cells

(2009) Geoffrey J Faulkner et al.   NATURE GENETICS

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death

(2008) L F Grochola et al.   BRITISH JOURNAL OF CANCER

DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

(2008) Srinivasan Yegnasubramanian et al.   CANCER RESEARCH

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

(2008) John L. Goodier et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer

(2008) Shuji Ogino et al.   JNCI-Journal of the National Cancer Institute

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

L1 recombination-associated deletions generate human genomic variation

(2008) K. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LINE-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer

(2007) J. PATTAMADILOK et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER