Review
Agriculture, Dairy & Animal Science
Isabella Adduci, Floriana Sajovitz, Barbara Hinney, Katharina Lichtmannsperger, Anja Joachim, Thomas Wittek, Shi Yan
Summary: This comprehensive review article summarizes the current control strategies, antigen engineering, and recent advances in anti-Haemonchus vaccine development for Haemonchus contortus, the most pathogenic blood-feeding parasitic nematode in sheep and goats. The review highlights the challenges and achievements in developing protective, efficient, and long-lasting vaccines to control H. contortus infection and discusses the potential of vaccines as an alternative control strategy. Novel developments addressing the challenge of glycosylation of putative vaccine candidates in recombinant form are also discussed.
Article
Agriculture, Dairy & Animal Science
Konstantinos V. Arsenopoulos, George C. Fthenakis, Eleni I. Katsarou, Elias Papadopoulos
Summary: This paper reviews the challenges of haemonchosis, a common parasitic infection in sheep and goats caused by Haemonchus parasites. Challenges include varying global prevalence, parasite resistance to antiparasitic drugs, difficulties in accurate diagnosis, and effective infection control.
Article
Immunology
Natalia G. C. Vasileiou, Daphne T. Lianou, Charalambia K. Michael, George C. Fthenakis, Vasia S. Mavrogianni
Summary: This review discusses the use of vaccination for preventing bacterial mastitis in ewes, particularly staphylococcal mastitis. The timing of vaccination during the final stage of pregnancy is important for protecting ewes during lambing. Vaccination can bring several benefits including reduced incidence risk of mastitis, increased milk production, and decreased use of antibiotics in flocks.
Article
Parasitology
Lucas Fiamoncini de Souza, Marcio Holsbach Costa, Beatriz Riet-Correa
Summary: This work presents a mobile application for decision assistance to treatment against parasitic infection in small ruminants. The app uses a semi-automated computer-aided procedure to assist farmers in applying anthelmintic treatment based on the Famacha (c) method. It achieves an accuracy of 87% using a support vector machine (SVM) classifier. This work is particularly useful for small property owners in regions with limited access to technical guidance.
VETERINARY PARASITOLOGY
(2023)
Article
Immunology
Cintia Hiromi Okino, Simone Cristina Meo Niciura, Paula Roberta Giaretta, Glaucia Roberta Melito, Rafaela Tami Ikeda Kapritchkoff, Isabella Barbosa dos Santos, Raquel Rubia Rech, Alessandro Pelegrine Minho, Sergio Novita Esteves, Ana Carolina de Souza Chagas
Summary: The association between ovine beta-globin polymorphisms and resistance against haemonchosis was studied, but there is a lack of research on local host responses. Sheep from two beta-globin haplotypes infected with Haemonchus contortus were evaluated. Lambs with the beta(A) allele showed improved resistance against clinical haemonchosis, with higher packed cell volume (PCV). Hb-AA animals had increased eosinophilia and Th2 profile in the abomasum, while Hb-BB animals had a stronger inflammatory response.
PARASITE IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Michaela Komaromyova, Dominika Mravcakova, Daniel Petric, Katarina Kuckova, Michal Babjak, Michaela Urda Dolinska, Alzbeta Konigova, Michaela Mad'arova, Ewa Pruszynska-Oszmalek, Adam Cieslak, Klaudia Cobanova, Zora Varadyova, Marian Varady
Summary: The study found that medicinal plants and organic selenium can improve the performance of infected lambs, aiding in the control of gastrointestinal nematode infection.
Article
Microbiology
Beyhan Sareyyupoglu, Serdar Uzar, Fahriye Sarac, Hakan Enul, Cumhur Adiay, Can Cokcaliskan, Abdullah Arslan, Gonca Oztap, Veli Gulyaz
Summary: Foot and mouth disease and Lumpy skin disease are contagious viral diseases that cause economic damage in the livestock industry. Researchers found that simultaneous vaccination of Foot and mouth disease and sheep pox or goat pox vaccines provided effective immunity against Lumpy skin disease.
VETERINARY MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Gerelmaa Ulziibat, Eran Raizman, Amarsanaa Lkhagvasuren, Chris J. M. Bartels, Orgikhbayar Oyun-Erdene, Bodisaikhan Khishgee, Clare Browning, Donald P. King, Anna B. Ludi, Nicholas A. Lyons
Summary: Vaccines are crucial in controlling foot-and-mouth disease outbreaks in Mongolia, but logistical challenges make delivering a two-dose primary vaccination course difficult in nomadic pastoralist systems. While highly potent vaccines have shown prolonged immunity, their effectiveness in field conditions with commercially available vaccines has not been confirmed. This study compared neutralizing titres in Mongolian sheep and cattle vaccinated with either a two-dose primary course or a single double-dose vaccine over a 6-month period. The results suggest that the single double-dose regimen may be a cost-effective approach for FMD control in Mongolia.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Parasitology
G. Suarez, P. Geldhof, J. Borloo, R. Perez-Caballero, D. Robaina, L. Buffoni, P. Alonzo, A. Martinez-Moreno, O. Correa, J. Tort, J. Perez, E. Claerebout
Summary: The research indicated that the dd-Co-ASP protein isolated from the bovine small intestinal parasite could protect cattle from infection, but was not effective against C. curticei infection.
VETERINARY PARASITOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Feliciano Milian-Suazo, Sara Gonzalez-Ruiz, Yesenia Guadalupe Contreras-Magallanes, Susana Lucia Sosa-Gallegos, Isabel Barcenas-Reyes, Germinal Jorge Canto-Alarcon, Elba Rodriguez-Hernandez
Summary: Bovine tuberculosis is a chronic infectious disease that poses significant veterinary and public health problems. In underdeveloped countries, the current control strategies have not been successful. The use of the BCG vaccine has been suggested to reduce the disease prevalence, and studies have shown its effectiveness in decreasing the number of animals with visible lesions and bacterial load. There is growing interest in integrating the vaccine into control programs, particularly in high-prevalence areas such as dairy cattle in Mexico.
Article
Immunology
Zahra Bamouh, Jihane Hamdi, Siham Fellahi, Slimane Khayi, Mohammed Jazouli, Khalid Omari Tadlaoui, Ouafaa Fassi Fihri, Eeva Tuppurainen, Mehdi Elharrak
Summary: This study compared the safety of two lumpy skin disease vaccine strains and found that the post-vaccination lesions may not be strain-dependent. There is a positive correlation between the vaccine dose and the appearance of adverse reactions, with higher dose leading to a higher percentage of animals reacting. Both vaccine strains induced solid immunity in vaccinated animals.
Article
Immunology
Swathi Gopalaiah, Kshama M. Appaiah, Shrikrishna Isloor, Dilip Lakshman, Ramesh P. Thimmaiah, Suguna Rao, Mahadevappa Gouri, Naveen Kumar, Kavitha Govindaiah, Avinash Bhat, Simmi Tiwari
Summary: Administering rabies pre-exposure prophylactic vaccine through intramuscular (IM) and intradermal (ID) routes proved to be effective and safe in protecting cattle against rabies. The ID route was more economical due to its dose-sparing effect. Both routes can be considered for pre-exposure prophylaxis.
Article
Infectious Diseases
Patricio Retamal, Pedro abalos, Raul Alegria-Moran, Nicolas Valdivieso, Martin Vordermeier, Gareth Jones, Karina Saadi, Carolina Perez Watt, Constanza Salinas, Constanza avila, Valentina Padilla, Belen Benavides, Romina Orellana
Summary: The study evaluated the efficacy of vaccinating dairy cattle with the BCG Russia strain in a high prevalence area of Chile for tuberculosis prevention. Results showed a significant reduction in infection rates and beneficial effects on milk production parameters.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Summary: Sheep infected with NSDV develop severe symptoms and may require euthanasia, while cattle only exhibit mild subclinical infection, but both species show seroconversion. In the future, serological monitoring programs for NSDV occurrence and spread should include not only sheep sera but also cattle sera.
Article
Agriculture, Dairy & Animal Science
Paula Gadicke, David Heath, Angela Medina-Brunet, Maria Carolina Siva-de La Fuente, Hellen Espinoza-Rojas, Carmen Villaguala-Pacheco, Makarena Rubilar, Carolina Cerda, Manuel Quezada, Daniela Rojas, AnaLia Henriquez, Marco Loyola, Carlos Landaeta-Aqueveque
Summary: This study evaluated the effectiveness of the Eg95 vaccine on sheep infection in a control program conducted in Chile. The results showed that while the vaccine was effective in reducing the size and fertility of cysts, it did not significantly reduce the infection rate in sheep. The timing and frequency of vaccination were found to be important factors in achieving better protection.
Article
Veterinary Sciences
Hornblenda Joaquina Silva Bello, Jose Gabriel Goncalves Lins, Ana Claudia Alexandre de Albuquerque, Gabriel Badial Ferreira, Monica Regina Vendrame Amarante, Alessandro Francisco Talamini do Amarante
Summary: This study evaluated the prophylactic and therapeutic effects of ivermectin and closantel on sheep with O. ovis infestation. The results showed that both antiparasitics had high efficacy against oestrosis, and O. ovis parasitism did not hinder the performance of lambs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Jordana Andrioli Salgado, Sthefany Kamile dos Santos, Jessea de Fatima Franca Biz, Matheus Borges de Carvalho, Fernanda Rigo, Breno Castello Branco Beirao, Alessandro Francisco Talamini do Amarante, Leandro Batista Costa, Cristina Santos Sotomaior
Summary: This study evaluated the levels of IgA in saliva, serum, and abomasal mucus in lambs infected with Haemonchus contortus. The results showed that IgA in saliva was correlated with the severity of infection and may serve as an immune correlate of protection against Haemonchus infection.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Parasitology
Poliana Araujo Pacheco, Helder Louvandini, Rodrigo Giglioti, Bruna Costa Rodrigues Wedy, Jessica Carolina Ribeiro, Cecilia Jose Verissimo, Jorge Freire da Silva Ferreira, Alessandro Francisco Talamini do Amarante, Luciana Morita Katiki
Summary: This study evaluated the anthelmintic activity of ivermectin combined with main terpenes of essential oils and phenolic compounds against the most important gastrointestinal nematode in small ruminant systems. The combination of ivermectin with limonene or quercetin was found to restore the anthelmintic effects against multi-drug-resistant nematodes.
VETERINARY PARASITOLOGY
(2022)
Article
Parasitology
Jose Gabriel G. Lins, Fabiana A. Almeida, Ana Claudia A. Albuquerque, Collette Britton, Alessandro F. T. Amarante
Summary: In comparison with European sheep breeds, Santa Ines sheep show greater resistance against Haemonchus contortus infections. This study found that Santa Ines lambs are able to mount a robust innate immune response at an early age and exhibit strong resistance against H. contortus infection.
VETERINARY PARASITOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Murilo Antonio Fernandes, Paulo de Mello Tavares Lima, Alessandro Francisco Talamini do Amarante, Adibe Luiz Abdalla, Helder Louvandini
Summary: The study aimed to evaluate the effects of dual parasite infection on ruminal fermentation and methane production, as well as hematological and biochemical parameters in sheep. The results showed that parasitic infection reduced dry matter intake, caused changes in blood parameters and ruminal fermentation patterns, and resulted in higher methane production by infected animals.
SMALL RUMINANT RESEARCH
(2022)
Article
Parasitology
Hornblenda Joaquina Silva Bello, Jose Gabriel Gonsalves Lins, Naiara Mirelly Marinho da Silva, Ana Claudia Alexandre de Albuquerque, Monica Regina Vendrame Amarante, Vitoldo Antonio Kozlowski Neto, Alessandro F. T. Amarante
Summary: This study assessed the suitability of PCR and ELISA as diagnostic methods for identifying Oestrus ovis larvae in naturally infested young sheep. The results showed that ELISA was more effective than PCR in identifying animals carrying O. ovis.
VETERINARY PARASITOLOGY
(2022)
Article
Veterinary Sciences
Ana Claudia A. Albuquerque, Fabiana A. Almeida, Cesar C. Bassetto, Alessandro F. T. Amarante
Summary: Limited information on the effects of targeted selective treatment (TST) on livestock productivity exists. This study aimed to evaluate the production performance of lambs naturally infected with gastrointestinal nematodes (GIN) under TST compared to suppressive anthelmintic treatments.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Parasitology
Simone Cristina Meo Niciura, Alessandro Pelegrine Minho, Jennifer McIntyre, Magda Vieira Benavides, Cintia Hiromi Okino, Sergio Novita Esteves, Ana Carolina de Souza Chagas, Alessandro Francisco Talamini do Amarante
Summary: This study optimized a 42-day in vitro culture protocol for Haemonchus contortus third-stage larvae using modified DMEM media. The acidic media and co-culture with Caco-2 cells were found to be more effective in promoting larvae development and viability compared to pH 7.4 DMEM.
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2023)
Article
Biochemistry & Molecular Biology
Vitoldo Antonio Kozlowski Neto, Elizabeth Moreira dos Santos Schmidt, Camila Peres Rubio, Naiara Mirelly Marinho da Silva, Renata Tardivo, Ciniro Costa, Paulo Roberto de Lima Meirelles, Jose Joaquin Ceron, Asta Tvarijonaviciute, Alessandro Francisco Talamini do Amarante
Summary: The trial aimed to evaluate the levels of oxidative stress biomarkers and biochemical analytes in crossbred lambs during the rearing phase in an integrated crop-livestock system (ICLS) for controlling gastrointestinal parasites. 36 crossbred lambs were divided into two groups, with one group supplemented with whole cottonseed (WCS) and the other serving as controls. The results showed that the inclusion of WCS was beneficial in controlling infection and increasing antioxidants while reducing oxidants in lambs naturally infected by gastrointestinal parasites. The combination of WCS and ICLS could effectively control gastrointestinal parasite infection without affecting production performance.
Article
Parasitology
Jose Gabriel Goncalves Lins, Ana Claudia Alexandre de Albuquerque, Fabiana Alves de Almeida, Collette Britton, Camila Malossi, Joao Pessoa de Araujo Junior, Helder Louvandini, Alessandro F. T. Amarante
Summary: This study sequenced the RNA of abomasal tissue in Santa Ines (SI) and Ile de France (IF) lambs to identify mucosa-specific transcript alterations related to Haemonchus contortus infection. SI lambs showed a stronger immune response and had higher levels of certain cell types associated with resistance to infection. Potential mechanisms and markers for H. contortus resistance were identified in this study.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
M. L. E. Chocobar, H. J. S. Bello, C. C. Bassetto, N. M. Silva-Marinho, L. M. N. Sato, C. Sperb, A. C. S. Chagas, A. F. T. Amarante
Summary: The aim of this study was to evaluate the behavior of a susceptible Haemonchus contortus isolate in comparison with a multiresistant field isolate in infecting lambs. The results showed that the susceptible isolate was able to infect lambs with similar pathogenicity to the resistant field isolate, indicating its potential to replace the resistant population.
SMALL RUMINANT RESEARCH
(2023)
Article
Parasitology
Patrizia Ana Bricarello, Leticia Rodrigues Costa, Cibele Longo, Jaqueline Seugling, Cesar Cristiano Basseto, Alessandro Francisco Talamini do Amarante, Maria Jose Hotzel
Summary: This study evaluated the relationship between foraging distance, parasitological and physiological factors in Crioula Lanada lambs. The results showed that animals approached the dung more frequently when radiation and temperature were higher. Paddock entry/exit, IgG and infective larvae quantity influenced the foraging distance over time. On the other hand, infective larvae quantity was influenced by infection level, fecal egg count, and corpuscular volume.
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2022)
Article
Parasitology
A. C. A. Albuquerque, F. A. Almeida, C. C. Bassetto, J. G. G. Lins, A. F. T. Amarante
Summary: This study evaluated the immune response to natural intestinal nematode infection in Santa Ines and Ile de France sheep breeds under two different anthelmintic treatment regimens. The results showed that Santa Ines lambs had higher levels of parasite-specific immunoglobulin G and A, as well as more mast cells and globule leukocytes in the intestinal mucosa. Furthermore, there were breed differences in the immune response to intestinal nematode infection.
JOURNAL OF HELMINTHOLOGY
(2022)
