Article
Immunology
Sumin Kim, Seo Hyeong Park, Won Hoon Choi, Min Jae Lee
Summary: This paper describes a protocol for measuring the activity of immunoproteasomes using commercially available fluorogenic peptide substrates. The results suggest that the most accurate assessment of immunoproteasome activity can be achieved by combining a specific substrate and an immunoproteasome inhibitor. This simple and reliable method may contribute to future studies on the role of immunoproteasomes in viral infection, inflammation, and tumorigenesis.
Article
Agricultural Engineering
Shiyu Song, Hongping Zhou, Linyun Xu, Zhicheng Jia, Guimin Hu
Summary: The effect of cutting parameters on the cutting performance of sisal leaves under the impact cutting was investigated. The experimental results showed that cutting parameters had a significant impact on the shear stress and cutting energy of sisal leaves. The proposed cutting method achieved optimal cutting parameters to reduce cutting force and cutting energy. The results provide an important basis for improving sisal leaf-cutting devices and developing economic sisal leaves harvesting equipment in the future.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Pharmacology & Pharmacy
Xin Xie, Ting -ting Shen, Hai-lian Bi, Zhuo-lin Su, Zi-qi Liao, Ying Zhang, Lei Shi, Yun-long Xia
Summary: This study found that melatonin protects against Ang II-induced AF by inhibiting proteasome activity and stabilizing ATRAP expression. These effects are partially dependent on melatonin receptor activation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Melina Frantzeskakis, Yousuke Takahama, Izumi Ohigashi
Summary: The thymus provides a microenvironment for T cell generation and selection, with cTECs expressing thymoproteasomes for optimal CD8(+) T cell positive selection, and mTECs expressing immunoproteasomes for self-tolerance in T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohammad Mahdi Doroodmand, Sina Owji
Summary: A novel electrosynthetic method utilizing layer-by-layer self-assembly of Salen-based nanowires has been developed as a capacitive pseudo-supercapacitor. The polymer synthesized using this method exhibited high stability and capacity performance during charge/discharge cycling.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Guohui Xing, Tingchen Du, Shujuan Liu, Yun Ma, Qiang Zhao
Summary: This article introduces a method to regulate the optical properties of iTMCs by changing their counterions. The modulation of emission wavelengths, emission lifetimes, and response behaviors can be achieved by adjusting the counterions. The article also summarizes the advances in multi-level information encryption and high-level anti-counterfeiting applications, as well as discusses the challenges and future directions related to this topic.
CHEMICAL COMMUNICATIONS
(2022)
Article
Mathematics, Applied
P. Martinez Coq, A. Rey, O. A. Rosso, R. Armentano, W. Legnani
Summary: The aim of this study is to develop a new methodology using informational tools for detecting patients with cardiac arrhythmias. The research shows that the proposed method, based on permutation entropy and statistical complexity, combined with supervised machine learning algorithms, achieves promising results in classifying ECG signals from patients with arrhythmias. The findings suggest the potential for using this method as a new marker for detecting cardiovascular pathologies.
Article
Materials Science, Ceramics
Xingbin Zhang, Hui Chen, Guangchun Xiao, Mingdong Yi, Jingjie Zhang, Zhaoqiang Chen, Qun Lin, Chonghai Xu
Summary: Graphene-coated SiC nanoparticles (SiC@G) with high dispersivity were incorporated into an Al2O3 matrix. The presence of graphene floating bands in SiC@G nanoparticles enhanced the bonds between Al2O3 particles and increased the contact area between graphene and the matrix. This unique core-shell structure improved the mechanical properties of the ceramic tools by making crack propagation more tortuous and increasing the energy consumed during the fracture process. The addition of SiC@G nanoparticles increased the fracture toughness by 75.6% and the flexural strength by 28.7%, and improved the cutting life by 18.1% while reducing the cutting force and friction coefficient.
CERAMICS INTERNATIONAL
(2023)
Article
Oncology
Raul Maia Falcao, Georgia Kokaraki, Wout De Wispelaere, Frederic Amant, Gustavo Antonio De Souza, Jorge Estefano Santana de Souza, Joseph Woodward Carlson, Tirzah Braz Petta
Summary: Uterine leiomyosarcoma (uLMS) is a rare and aggressive tumor with high heterogeneity. This study identified overexpression of the immunoproteasome pathway in uLMS and classified uLMS into immune-related and ECM-related subtypes with different candidate mechanisms of malignancy.
Article
Materials Science, Multidisciplinary
Minggang Wang, Fazhan Wang, HongBo Wang, Jingcheng Zhang, Xiangnan Zhao, Hong Wu
Summary: The aim of this research was to explore the influence of bismuth (Bi) nanoparticles on the single-crystal iron (Fe) nano-cutting process using molecular dynamics (MD) simulations. The presence of Bi nanoparticles affected the cutting force, Von_mises stress distribution, and dislocation generation. Results showed that cutting force and Von_mises stress decreased when the tool cut through Bi nanoparticles, due to their smaller hardness and deformation.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Review
Cell Biology
Michael Basler, Marcus Groettrup
Summary: The immunoproteasome is a special type of proteasome induced under inflammatory conditions, contributing to protein homeostasis in cells and involved in immune response, T cell expansion, and inflammatory diseases. Targeting the immunoproteasome has shown therapeutic effectiveness in cancer, autoimmune diseases, and transplantation in preclinical animal models.
Article
Optics
Jae Sung Shin, Seong Y. Oh, Seung-Kyu Park, Hyunmin Park, Jonghwan Lee
Summary: In underwater laser cutting, oblique cutting significantly improves the initial cutting speed of thick steel plates, eliminating the need for low initial cutting speeds.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Alina A. Grineva, Oleg A. Filippov, Yves Canac, Jean-Baptiste Sortais, Sergei E. Nefedov, Noel Lugan, Vincent Cesar, Dmitry A. Valyaev
Summary: The study involved lithiation and transmetalation to prepare a heterobimetallic complex with an anionic ditopic imidazol-2,4-diylidene ligand, which was further converted to a bis(iron) complex with metalated carbenic groups. It was found that metalation significantly affects the electronic donation properties of the ligand.
INORGANIC CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Gokhan Aydin, Izzet Karakurt, Mohammad Reza Amiri, Serkan Kaya
Summary: This study investigates the effects of two-pass abrasive waterjet cutting on rocks and compares it with one-pass cutting mode. The results indicate that two-pass cutting improves smooth depth and surface quality, and reduces the inclination of the kerf wall.
Article
Automation & Control Systems
Michael Storchak, Thomas Stehle, Hans-Christian Moehring
Summary: The study focused on the impact of thermal properties of machined materials on thermal machining characteristics, developing a methodology based on the determination of tangential stress. Thermal properties of the materials were calculated based on this stress and cutting temperature, with the developed FE cutting model achieving a deviation between experimental and simulated temperature values ranging from approximately 7.5% to 14.4%.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2022)