Review
Chemistry, Multidisciplinary
Srushti Mahajan, Mayur Aalhate, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: Lymphomas are hematological malignancies that originate in lymph tissues and tend to spread to other organs. Traditional strategies like surgery and local treatment are not suitable for managing these tumors, but novel targeted therapies and antibody-mediated treatments have been revolutionary in their management. Nanomedicine provides targeted delivery of therapeutic agents, reducing drug resistance and toxicities, and also offers personalized medicine for different types of lymphomas.
JOURNAL OF CONTROLLED RELEASE
(2022)
Editorial Material
Oncology
Marija Trajkovic-Arsic, Elavarasan Subramani
Summary: Altered cellular metabolism is a key characteristic of cancer, and oncogenic signaling cascades drive this metabolic rewiring, allowing for tumor development, therapy resistance, and metastasis. The Collection on 'Cancer Metabolism' focuses on the current research and personalized medicine approach to target metabolism for cancer therapy.
Review
Chemistry, Multidisciplinary
Umme Farwa, Muhammad Asam Raza
Summary: Diabetes mellitus is a metabolic disorder characterized by increased blood sugar levels, and synthetic agents have been increasingly used for its treatment. This study investigated the core structures of drugs and their interactions with different enzymes in diabetic assays. Molecular docking experiments showed interactions between certain amino acid residues and antidiabetic molecules. The review organized data on the synthesis of heterocyclic compounds and their potential in treating diabetes.
Review
Oncology
Haowen Jiang, Albert M. Li, Jiangbin Ye
Summary: The term 'magic bullet' refers to a medicine that can specifically and efficiently target a disease. Niclosamide, an FDA-approved drug for treating tapeworm infections, has shown broad anti-cancer activity and potential in improving immunotherapy. Clinical trials are currently underway to evaluate its therapeutic effect on cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Hematology
Sara Ghorashian, Martin Pule
Summary: This study investigates the potential of using CAR T cells targeting Siglec-6 in acute myeloid leukemia, which may spare normal hematopoiesis and avoid interfering with the normal process of blood cell production.
Review
Pharmacology & Pharmacy
Leon G. Leanse, Carolina dos Anjos, Sana Mushtaq, Tianhong Dai
Summary: This review provides an update on the recent studies exploring the antimicrobial effects of antimicrobial blue light (aBL) in the treatment of multidrug-resistant infections. The review focuses on the efficacy of aBL against different microbes, identification of endogenous chromophores and targets of aBL, resistance development to aBL, safety of aBL against host cells, and synergism of aBL with other agents. The review also offers insights into the future of aBL.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Engineering, Electrical & Electronic
Clemens Linnhoff, Philipp Rosenberger, Hermann Winner
Summary: The research introduces a novel object-based lidar simulation approach that aims to identify and model sensor effects, balance effect fidelity and computation time, and compare it with ray tracing simulation. The results show that the new approach outperforms the traditional ray tracing method significantly in terms of computation time, with potential for future applications.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Mi-Young Kim, Sang-Woon Choi
Summary: Walnut, as a natural remedy, contains various beneficial components and has been regarded as a natural functional food due to its nutrients and bioactive compounds. Walnut-enriched diets have shown positive effects on heart health, cancer prevention, and metabolic disorders, and have been proposed to modulate the development and progression of non-alcoholic fatty liver disease.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Bakr Ahmed, Anuradha Sharma, Zakiya Usmani, Garima Sharma, Joga Singh, Radhika Yadav, Indu Sharma, Indu Pal Kaur
Summary: According to the World Cancer Research Fund International (WCRFI), ovarian cancer is the 8th most prevalent cancer in women. Current treatments face challenges due to the emergence of resistance, recurrence, and harmful side effects. Nanotechnology-based approaches that target multiple receptors offer an effective therapy with high synergy and low side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Health Care Sciences & Services
Ashagrachew Tewabe, Atlaw Abate, Manaye Tamrie, Abyou Seyfu, Ebrahim Abdela Siraj
Summary: Nanomedicine is an advanced concept that uses targeted drug delivery systems to deliver drugs directly to specific areas in the body, reducing the amount of drug needed for treatment and overcoming the toxic effects of traditional drug delivery. This field involves various carrier systems, such as colloidal and multiparticulate carriers, polymers, and cellular/subcellular systems.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Review
Biochemistry & Molecular Biology
Chandra N. Jack, Renee H. Petipas, Tanya E. Cheeke, Jennifer L. Rowland, Maren L. Friesen
Summary: Microbial inoculants have gained popularity for regulating plant traits and productivity in the past decade as a sustainable and gentle alternative to fertilizers, pesticides, and genetic modification. However, the potential for microbial invasions poses a risk, leading to the need for measures outlined in the TREE approach to prevent such invasions and stimulate proactive discussions on best practices.
TRENDS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
John Ndayishimiye, Tushar Kumeria, Amirali Popat, James Robert Falconer, Mark A. T. Blaskovich
Summary: Bacterial infections continue to be a major cause of mortality and morbidity worldwide, despite the use of existing antibiotics and efforts to discover new ones. The emergence of antibiotic-resistant strains highlights the need for new bactericidal therapies. Nanomaterial-based strategies offer promise due to their ability to circumvent resistance mechanisms. This review discusses novel nanomaterial-based formulations targeting bacterial infections and resistance, along with their types and activities as delivery systems or antimicrobials, and issues of toxicity.
ACS INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Vitali Sintchenko, Verlaine Timms, Eby Sim, Rebecca Rockett, Nathan Bachmann, Matthew O'Sullivan, Ben Marais
Summary: Virulence arresting drugs (VAD) are a new class of antimicrobial treatments that weaken bacteria rather than killing them. The use of pathogen genomics can help optimize the use of VAD drugs, and genomic identification and characterization of VAD targets in clinical isolates can enhance antimicrobial stewardship and pharmacovigilance, creating market opportunities for biotech companies and diagnostic laboratories.
FRONTIERS IN MEDICINE
(2021)
Review
Chemistry, Medicinal
Sergio Wittlin, Pascal Maeser
Summary: The specificity of drug action is based on the concept of drug targets, looking for proteins that are essential for the pathogen but not present in human cells. Some drugs can selectively kill pathogens by activating prodrugs inside the pathogen while remaining inactive in the host.
ACS INFECTIOUS DISEASES
(2021)
Review
Chemistry, Multidisciplinary
Mohammad Okkeh, Nora Bloise, Elisa Restivo, Lorenzo De Vita, Piersandro Pallavicini, Livia Visai
Summary: Bacterial resistance is escalating, hindering pharma companies from investing in new antibiotic entities to combat the global challenge. Medical nanotechnology utilizing inorganic nanomaterials like gold and silver show potential antibacterial efficacies, with gold nanoparticles gaining specific attention due to their biocompatibility and optical properties.
Article
Biochemistry & Molecular Biology
Yun Wang, John Kendall, Jennifer S. Cavet, David P. Giedroc
Article
Immunology
David Corbett, Jiahui Wang, Stephanie Schuler, Gloria Lopez-Castejon, Sarah Glenn, David Brough, Peter W. Andrew, Jennifer S. Cavet, Ian S. Roberts
INFECTION AND IMMUNITY
(2012)
Article
Infectious Diseases
Nicola J. Beresford, Debbie Mulhearn, Bruce Szczepankiewicz, Gang Liu, Michael E. Johnson, Anthony Fordham-Skelton, Cele Abad-Zapatero, Jennifer S. Cavet, Lydia Tabernero
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2009)
Article
Biochemistry & Molecular Biology
Deenah Osman, Kevin J. Waldron, Harriet Denton, Clare M. Taylor, Andrew J. Grant, Pietro Mastroeni, Nigel J. Robinson, Jennifer S. Cavet
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Immunology
Clare M. Taylor, Deenah Osman, Jennifer S. Cavet
MICROBIAL PATHOGENESIS
(2009)
Article
Biochemistry & Molecular Biology
David Corbett, Stephanie Schuler, Sarah Glenn, Peter W. Andrew, Jennifer S. Cavet, Ian S. Roberts
MOLECULAR MICROBIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Deenah Osman, Carl J. Patterson, Kathryn Bailey, Karl Fisher, Nigel J. Robinson, Stephen E. J. Rigby, Jennifer S. Cavet
MOLECULAR MICROBIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Deenah Osman, Jennifer S. Cavet
NATURAL PRODUCT REPORTS
(2010)
Article
Microbiology
Heba Barnawi, Nader Masri, Natasha Hussain, Bushra Al-Lawati, Evita Mayasari, Aleksandra Gulbicka, Adrian J. Jervis, Min-Hsuan Huang, Jennifer S. Cavet, Dennis Linton
Editorial Material
Microbiology
Karrera Djoko, Jennifer Cavet
Article
Immunology
David Corbett, Marie Goldrick, Vitor E. Fernandes, Kelly Davidge, Robert K. Poole, Peter W. Andrew, Jennifer Cavet, Ian S. Roberts
INFECTION AND IMMUNITY
(2017)
Proceedings Paper
Immunology
Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E. P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, Jeffrey N. Weiser
TRACE METALS AND INFECTIOUS DISEASES
(2015)
Article
Biochemistry & Molecular Biology
Duncan R. Campbell, Kaye E. Chapman, Kevin J. Waldron, Stephen Tottey, Sharon Kendall, Gabriele Cavallaro, Claudia Andreini, Jason Hinds, Neil G. Stoker, Nigel J. Robinson, Jennifer S. Cavet
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Immunology
Erik Ladomersky, Aslam Khan, Vinit Shanbhag, Jennifer S. Cavet, Jefferson Chan, Gary A. Weisman, Michael J. Petris
INFECTION AND IMMUNITY
(2017)
