Article
Microbiology
Hao Wang, Fenfang Liao, Junmo Xie, Wenbo Gao, Min Wang, Jieting Huang, Ru Xu, Qiao Liao, Zhengang Shan, Yourong Zheng, Xia Rong, Chengyao Li, Yongshui Fu
Summary: The study revealed that E2G/A/V/D mutations significantly influence the detection of HBsAg, with different underlying mechanisms for OBI caused by E2 mutations in genotype B and genotype C. Additionally, E2G/A mutations may result in a N-terminal truncated S protein, contributing to HBsAg secretion impairment in OBI.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Fan Zhang, Zhaogeng Yang, Cong Dai, Qiyu He, Zhaochao Liang, Tianxu Liu, Weijin Huang, Youchun Wang, Lin Wang, Ling Wang
Summary: This study demonstrated that the HEV vaccine could induce high titers of protective antibodies against HEV in pregnant rabbits within a short period of time, and these antibodies could be transferred to neonates through the placenta and breast milk, providing protection against HEV infection. This suggests that HEV 239 vaccine could be considered for maternal vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Wenshi Wang, Florian A. Lempp, Franziska Schlund, Lisa Walter, Charlotte C. Decker, Zhenfeng Zhang, Yi Ni, Stephan Urban
Summary: Research has shown that HDVs from different genotypes replicate with varying efficacies. Variations in HDV genomes and HBV envelope proteins are major determinants of HDV egress and entry efficacy.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Man-Fung Yuen, Seng-Gee Lim, Robert Plesniak, Keiji Tsuji, Harry L. A. Janssen, Cristina Pojoga, Adrian Gadano, Corneliu P. Popescu, Tatyana Stepanova, Tarik Asselah, Gheorghe Diaconescu, Hyung Joon Yim, Jeong Heo, Ewa Janczewska, Alexander Wong, Nevin Idriz, Michio Imamura, Giuliano Rizzardini, Koichi Takaguchi, Pietro Andreone, Manuela Arbune, Jinlin Hou, Sung Jae Park, Andrei Vata, Jennifer Cremer, Robert Elston, Tamara Lukic, Geoff Quinn, Lauren Maynard, Stuart Kendrick, Helene Plein, Fiona Campbell, Melanie Paff, Dickens Theodore, B-Clear Study Grp
Summary: Bepirovirsen treatment for 24 weeks at a dose of 300 mg per week resulted in sustained loss of hepatitis B surface antigen (HBsAg) and HBV DNA in 9%-10% of patients with chronic HBV infection. Larger and longer trials are needed to assess the efficacy and safety of bepirovirsen.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Percy A. Knolle, Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, Ulrike Protzer
Summary: Chronic hepatitis B affects over 250 million individuals worldwide, with prophylactic vaccination only establishing protective immunity but not eliminating HBV infections in patients. Current research focuses on therapeutic vaccination strategies and additional immune stimulation measures to improve efficacy in treating chronic hepatitis B.
Article
Agronomy
Monika Grzanka, Lukasz Sobiech, Grzegorz Skrzypczak, Tomasz Piechota
Summary: The pH of the spray liquid affects the efficacy of herbicides, adjusting parameters can reduce pesticide use. Different herbicides have varying effects on controlling oilseed rape, with those containing mesotrione and bromoxynil having the greatest impact on photosystem II activity.
Article
Virology
Stephen D. Graham, Huy A. Tu, Benjamin D. McElvany, Nancy R. Graham, Ariadna Grinyo, Edgar Davidson, Benjamin J. Doranz, Sean A. Diehl, Aravinda M. de Silva, Alena Janda Markmann
Summary: The study characterized a strongly neutralizing antibody B11F isolated from a patient who recovered from ZIKV, revealing a new target site on the viral envelope. This is relevant for understanding how antibodies block infection and guiding the design and evaluation of candidate vaccines.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Gyu Song, Ji Yoon Kim, Eun Bi Jeon, So Hee Kim, Min Soo Heu, Jung-Suck Lee, Jin-Soo Kim, Shin Young Park
Summary: In this study, dielectric barrier discharge plasma (DBDP) was used to sterilize oysters without affecting their quality. The total titers of HAV in the suspension and on the oysters were significantly reduced after DBDP treatment. PMA was able to distinguish the infectivity of HAV and there were no negative effects on oyster quality.
APPLIED SCIENCES-BASEL
(2023)
Review
Microbiology
Shiv Kumar, Shabnam Ansari, Sriram Narayanan, C. T. Ranjith-Kumar, Milan Surjit
Summary: Viral hepatitis is a significant global public health concern. Zinc has been found to exhibit antiviral activity against hepatitis-causing viruses, suggesting its potential therapeutic benefits in reducing the burden of viral hepatitis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Iman Waheed Khan, Mati Ullah Dad Ullah, Mina Choudhry, Mukarram Jamat Ali, Muhammad Ashar Ali, Sam L. K. Lam, Pir Ahmad Shah, Satinder Pal Kaur, Daryl T. Y. Lau
Summary: HBV infection is a global public health issue and a major cause of cirrhosis and HCC; current therapies for chronic hepatitis B and D are suboptimal and new therapeutic agents targeting different stages of viral replicative cycle are necessary; promising compounds such as entry inhibitors, cccDNA inhibitors, siRNAs, capsid assembly modulators and nucleic acid polymers are in various stages of clinical development.
Article
Pharmacology & Pharmacy
Charlotte Bach, Julie Lucifora, Marion Delphin, Laura Heydmann, Margaux J. Heuschkel, Caroline Pons, Kaku Goto, Els Scheers, Catherine Schuster, David Durantel, Frederik Pauwels, Thomas F. Baumert, Eloi R. Verrier
Summary: Chronic hepatitis D, caused by super-infection of hepatitis B virus (HBV)-infected hepatocytes with hepatitis D virus (HDV), is the most aggressive form of chronic viral hepatitis. Further improvement in therapy is needed to address the unmet medical need, which requires a more detailed characterization of virus-host interactions for the identification of novel therapeutic targets.
ANTIVIRAL RESEARCH
(2023)
Article
Microbiology
Jyoti Gupta, Minnah Irfan, Niranjan Ramgir, K. P. Muthe, A. K. Debnath, Shabnam Ansari, Jaya Gandhi, C. T. Ranjith-Kumar, Milan Surjit
Summary: Zinc salts exhibit antiviral activity against HEV and HCV, with zinc oxide nanoparticles showing higher efficacy. These nanoparticles are noncytotoxic to cells and have potential therapeutic benefits for HEV and HCV.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Samina Ejaz, Iqra Abdullah, Waqas Nazir Malik, Shazia Anjum, Muhammad Ashraf, Naveed Akhtar, Aurangzeb Khan, Yasir Hameed, Muhammad Usman, Usman Cheema, Safeena Sidiq
Summary: This study aims to investigate the prevalence and associated risk factors of hepatitis among students and employees in Pakistan and implement measures to make IUB hepatitis free. The study found that hepatitis is more prevalent in men and is associated with sharing of needles and certain behavioral and medical factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Romain Marlin, Delphine Desjardins, Vanessa Contreras, Guillaume Lingas, Caroline Solas, Pierre Roques, Thibaut Naninck, Quentin Pascal, Sylvie Behillil, Pauline Maisonnasse, Julien Lemaitre, Nidhal Kahlaoui, Benoit Delache, Andres Pizzorno, Antoine Nougairede, Camille Ludot, Olivier Terrier, Nathalie Dereuddre-Bosquet, Francis Relouzat, Catherine Chapon, Raphael Ho Tsong Fang, Sylvie van der Werf, Manuel Rosa Calatrava, Denis Malvy, Xavier de Lamballerie, Jeremie Guedj, Roger Le Grand
Summary: Repurposed antiviral drugs are valuable resources for outbreak defense, but rigorous evaluation in large animal models is crucial for successful clinical implementation. This study evaluates the antiviral activity of favipiravir against Zika virus and SARS-CoV-2 in cynomolgus macaques, highlighting its potential for clinical investigations against Zika virus but advising against its use for SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jun-Gyu Park, Fatai S. Oladunni, Mohammed A. Rohaim, Jayde Whittingham-Dowd, James Tollitt, Matthew D. J. Hodges, Nadin Fathallah, Muhsref Bakri Assas, Wafaa Alhazmi, Abdullah Almilaibary, Munir Iqbal, Pengxiang Chang, Renee Escalona, Vinay Shivanna, Jordi B. Torrelles, John J. Worthington, Lucy H. Jackson-Jones, Luis Martinez-Sobrido, Muhammad Munir
Summary: The study demonstrates that a Newcastle disease virus-based vectored-vaccine shows strong immunogenicity, safety, and protective efficacy in mice and hamsters. Animals vaccinated with this vaccine exhibit significantly decreased infection and pathological lesions following SARS-CoV-2 challenge, as well as reduced shedding of the virus.
Article
Microbiology
Anupriya S. Kulkarni, Masad J. Damha, Raymond F. Schinazi, Hongmei Mo, Brian Doehle, Selena M. Sagan, Matthias Gotte
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Cell Biology
Said Izreig, Bozena Samborska, Radia M. Johnson, Alexey Sergushichev, Eric H. Ma, Carine Lussier, Ekaterina Loginicheva, Ariel O. Donayo, Maya C. Poffenberger, Selena M. Sagan, Emma E. Vincent, Maxim N. Artyomov, Thomas F. Duchaine, Russell G. Jones
Review
Chemistry, Medicinal
Maaran M. Rajah, Ryan D. Pardy, Stephanie A. Condotta, Martin J. Richer, Selena M. Sagan
ACS INFECTIOUS DISEASES
(2016)
Review
Virology
Peter Sarnow, Selena M. Sagan
ANNUAL REVIEW OF VIROLOGY, VOL 3
(2016)
Editorial Material
Virology
Trisha R. Barnard, Maaran Michael Rajah, Selena M. Sagan
Article
Microbiology
Ryan D. Pardy, Maaran M. Rajah, Stephanie A. Condotta, Nathan G. Taylor, Selena M. Sagan, Martin J. Richer
Article
Anesthesiology
Sophie Breton, Janet van Vlymen, Sean Xia, Ronald R. Holden, Rachel Phelan, Selena M. Sagan, Melanie Jaeger
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2018)
Article
Biochemistry & Molecular Biology
Yalena Amador-Canizares, Annie Bernier, Joyce A. Wilson, Selena M. Sagan
NUCLEIC ACIDS RESEARCH
(2018)
Article
Virology
Sergio P. Alpuche-Lazcano, Craig R. McCullogh, Olivier Del Corpo, Elodie Rance, Robert J. Scarborough, Andrew J. Mouland, Selena M. Sagan, Mauro M. Teixeira, Anne Gatignol
Review
Virology
Annie Bernier, Selena M. Sagan
Article
Multidisciplinary Sciences
Camille A. Juzwik, Sienna Drake, Marc-Andre Lecuyer, Radia Marie Johnson, Barbara Morquette, Yang Zhang, Marc Charabati, Selena M. Sagan, Amit Bar-Or, Alexandre Prat, Alyson E. Fournier
SCIENTIFIC REPORTS
(2018)
Article
Virology
Trisha R. Barnard, Maaran M. Rajah, Selena M. Sagan
Article
Virology
Sophie E. Cousineau, Marylin Rheault, Selena M. Sagan
Summary: This study reveals the important role of the cellular RNA-binding protein PCBP1 in the hepatitis C virus (HCV) life cycle. Knockdown of PCBP1 leads to a decrease in viral RNA accumulation but an increase in extracellular viral titers. PCBP1 knockdown does not directly affect viral entry, translation, RNA stability, or replication, but results in an overall increase in infectious particle secretion. Blocking virus secretion can partially restore the viral RNA accumulation decreased by PCBP1 knockdown.
Article
Chemistry, Physical
Elnaz Alebrahim, Hediyeh Khatibnezhad, Morvarid Mohammadian Bajgiran, Magan Solomon, Chen Liang, Selena M. Sagan, Rogerio S. Lima, Joerg Oberste Berghaus, Maniya Aghasibeig, Christian Moreau
Summary: Novel antiviral coatings, specifically titanium dioxide coatings, show potential for mitigating the transmission of viral pathogens. This research evaluated the antiviral performance of thermally sprayed TiO2 coatings and TiO2 composites with other oxides, such as Cu2O and Al2O3, under various light conditions. The coatings exhibited comparable or slightly better antiviral activity compared to copper, with the highest activity observed being 20% to 50% higher than that of a pure copper plate.
Article
Gastroenterology & Hepatology
Sarwat Khan, Annie Bernier, Dustin Dapp, Emmanuel Fortier, Mel Krajden, Alexandra King, Jason Grebely, Selena M. Sagan, Curtis L. Cooper, Angela M. Crawley
CANADIAN LIVER JOURNAL
(2018)