Article
Plant Sciences
Angela Pinheiro, Isabel Martins, Artur Bento, Rita Escorcio, Carolina Nunes, Adelia Varela, Joao Nunes, Carlos A. M. Afonso, Cristina Silva Pereira
Summary: Pinus pinaster forestry has a significant impact on the national economy in Portugal, but oleoresin production has decreased due to competition from low-cost producers in other countries. The chemical composition of rosin derived from Pinus pinaster in Portugal is consistent regardless of forest location, with abietic acid and dehydroabietic acid as the major components.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Parasitology
Anand Chakroborty, Deiniol Pritchard, Marc E. Bouillon, Anna Cervi, Alan Cookson, Charlotte Wild, Caroline Fenn, Joseph Payne, Peter Holdsworth, Colin Capner, Jenna O'Neill, Gilda Padalino, Josephine Forde-Thomas, Sandeep Gupta, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Summary: Control of liver fluke infections is a significant challenge in the livestock sector due to drug resistant parasites. This study evaluated the anthelmintic activities of chemically modified abietic acid analogues against F. hepatica and found moderate activity in one analogue, but it also showed toxicity to mammalian cells. Therefore, further medicinal chemistry improvements are needed to consider these analogues as potential anthelmintics against liver fluke pathogens.
VETERINARY PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
Magd M. Badr, Ahmed Awadallah-F, Ahmed M. Azzam, A. H. Mady
Summary: The influence of gamma-ray on rosin natural gum was studied. It was found that rosin irradiated at different doses exhibited enhanced antimicrobial activity, especially when irradiated at 40 kGy, showing significant inhibition effect on both Gram-positive and Gram-negative bacteria.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Olga V. Tsepaeva, Andrey V. Nemtarev, Tatiana N. Pashirova, Michail V. Khokhlachev, Anna P. Lyubina, Syumbelya K. Amerkhanova, Alexandra D. Voloshina, Vladimir F. Mironov
Summary: This study focuses on the development of new cationic triphenylphosphonium amphiphilic conjugates of glycerolipid type as antitumor agents. These conjugates target mitochondria and can be used for mitochondrial delivery systems. The introduction of terpenoid fragments enhances the cytotoxicity towards tumor cells, including breast carcinoma and prostate adenocarcinoma.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Thaissa S. Beck, Mara de Mattos, Carlos R. T. Jortieke, Jean C. B. Vieira, Camila M. Verdi, Roberto C. V. Santos, Michele R. Sagrillo, Aline Rossato, Larissa da Silva Silveira, Clarissa P. Frizzo
Summary: Amino acid-based ionic liquids exhibit specific properties in thermal stability, heat capacity, antimicrobial activity, and cytotoxicity. It was found in the study that amino acid-based anions can reduce the thermal stability of mono and dicationic AAILs, and AAILs with more carbon chains have lower glass transition temperature.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
Mariana N. Costa, Roberto N. Silva
Summary: Cancer cells have higher proliferation rates and increased demand for amino acids compared to normal cells, which has been exploited for the development of anticancer drugs like L-asparaginase. Additionally, L-lysine alpha-oxidase, an enzyme of L-amino acid oxidase family, has been studied as a potential antineoplastic agent.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Summary: This study investigated the potential of combining the LAT1 inhibitor nanvuranlat with cytotoxic anticancer drugs. The results showed that nanvuranlat in combination with various cytotoxic anticancer drugs significantly inhibited the growth of pancreatic cancer cells, with gemcitabine showing the highest combination effect. Moreover, nanvuranlat also demonstrated growth inhibition in pancreatic and biliary tract cancer cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Plant Sciences
Won-Jin Kim, Woong Kim, Jang-Mi Bae, Jungsoo Gim, Seok-Jun Kim
Summary: Gastric cancer is a highly lethal malignancy with limited treatment options, making the development of targeted anticancer drugs crucial. Dehydroabietic acid (DAA) has been found to inhibit gastric cancer cell proliferation by downregulating survivin expression, showcasing its potential as a novel anticancer agent for gastric cancer.
Article
Multidisciplinary Sciences
Manuel J. Mallen-Ponce, Maria Esther Perez-Perez, Jose L. Crespo
Summary: This study reveals that carbon assimilation through the Calvin-Benson-Bassham cycle regulates TOR signaling in the model microalga Chlamydomonas reinhardtii, likely through the synthesis of key amino acids.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Anna S. Barashkova, Vera S. Sadykova, Victoria A. Salo, Sergey K. Zavriev, Eugene A. Rogozhin
Summary: High-cationic biologically active peptides, termed Nigellothionins, were isolated from black cumin seeds and classified as class I thionin subfamily members. These peptides play a role in plant innate immunity and exhibit antifungal properties. Nigellothionins show potential as natural compounds for antifungal and anti-proliferative applications based on their cytotoxic and antifungal activities.
Article
Biochemistry & Molecular Biology
Lingling Li, Yanran Xu, Zhuo Xu, Chunhua Wu, Qian Chen, Kaimeng Xu, Zhengjun Shi
Summary: The bioactivities of pristine chitosan are weak compared with commercial chemicals, hindering its application in food packaging and preservation. By modifying chitosan with dehydroabietic acid (DHA), a safe and biologically derived fruit preservative with excellent antifungal properties can be obtained. The antifungal activities of the modified chitosans against Penicillium digitutim and Penicillium italicum were investigated, showing that the DHA conjugated at C-6 with a free amino group at C-2 exhibited the strongest antifungal effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Pharmacology & Pharmacy
Iris Neto, Eva Maria Dominguez-Martin, Epole Ntungwe, Catarina P. Reis, Milica Pesic, Celia Faustino, Patricia Rijo
Summary: The study evaluated the antimicrobial activity of dehydroabietic acid (DHA) as an antibiofilm agent, testing it against various Gram-positive, Gram-negative bacteria, and yeasts. The results showed that DHA demonstrated high efficiency and potential in combating bacteria and inhibiting biofilm formation.
Article
Biochemistry & Molecular Biology
Sarvin Shirani, Jaleh Varshosaz, Mahboubeh Rostami, Mina Mirian
Summary: In this study, a redox-sensitive micelle was designed for targeted delivery of Ribociclib to breast cancer cells. The micelle showed promising redox sensitivity and high cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Article
Engineering, Chemical
Yanmin Qin, Xiaopeng Chen, Linlin Wang, Xiaojie Wei, Hairong Mo, Xuejuan Wei, Jiezhen Liang
Summary: This study determined the vapor-liquid equilibrium data of the systems of p-cymene and (-)-beta-caryophyllene, as well as p-cymene, (-)-beta-caryophyllene, and dehydroabietic acid. The results showed that the addition of dehydroabietic acid significantly affected the separation of p-cymene and (-)-beta-caryophyllene. The NRTL model was found to be the most suitable for predicting the behavior of the system based on the experimental data.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
