BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta

Four phenolic acids, namely 2-[(Z)-heptadec-I1-enyl]-6-hydroxybenzoic acid (1), 2-[(6Z.9Z,12Z)-heptadeca-6,9,12-trienyI]-6-hydroxybenzoic acid (2), 2-[(9Z,12Z)-heptadeca-9,12-dienyl]-6-hydroxybenzoic acid (3), and 2-hydroxy-6-(12-phenyldodecyl)benzoic acid (4), and one sesquiterpenc, asperpenoid (5), were isolated from the 95% EtOH extract of the roots of Homalomena occulta, among which 1, 2, and 5 represent new compounds. Further, the phenolic acids 1-4 exhibited BACE (beta-secretase) inhibitory activity with IC50 values of 6.23+/-0.94, 6.28+/-0.63, 7.93+/-0.38, and 7.65+/-0.62 mu M. respectively.