期刊
ACS CHEMICAL NEUROSCIENCE
卷 6, 期 11, 页码 1781-1788出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.5b00189
关键词
Poly-L-lactic acid; magnetic nanoparticle; electrospun fiber; nerve growth factor; neurite extension
资金
- NSF [1150125]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1150125] Funding Source: National Science Foundation
Nerve growth factor releasing composite nanoparticles (NGF-cNPs) were developed to direct the extension of neurite outgrowth from dorsal root ganglia (DRG). Iron oxide magnetic nanoparticles were incorporated into poly-L-lactic acid (PLLA) nanoparticles in order to position the NGF-cNPs in a culture dish. Neurites growing from DRG extended toward the NGF released from the NGF-cNPs. DRG were then cultured on aligned PLLA microfibers in the presence of NGF-cNPs, and these biomaterials combined to align DRG neurite extension along one axis and preferentially toward the NGF-cNPs. This combinatorial biomaterial approach shows promise as a strategy to direct the extension of regenerating neurites.
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