Article
Environmental Sciences
Jacob Fox, Francesca Macaluso, Camille Moore, Elise Mesenbring, Richard J. Johnson, Richard F. Hamman, Katherine A. James
Summary: The study found that an increase in urine tungsten concentration is significantly associated with a decreased time-to-CKD and may be related to CKD of unknown origin (CKDu). Elevated tungsten levels in urine may have a primary effect on the kidneys, which needs further evaluation in future studies.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Physical
Xiang Chen, Yan Zhao, Yuan Sun, Long Wang, Hongwei Xie, Jiakang Qu, Shuaibo Gao, Dihua Wang, Huayi Yin
Summary: This study presents a molten salt electrolyzer approach for the simultaneous recovery of alloy scrap and CO2, enabling the reuse of valuable materials. The oxides in the molten salt and CO2 are converted to water-soluble sulfates and carbon, respectively, achieving high recovery rates. This method improves energy efficiency and closes the metal and carbon cycles.
SUSTAINABLE ENERGY & FUELS
(2022)
Article
Cardiac & Cardiovascular Systems
Chiara Bruzzone, Ruben Gil-Redondo, Marisa Seco, Rocio Barragan, Laura de la Cruz, Claire Cannet, Hartmut Schaefer, Fang Fang, Tammo Diercks, Maider Bizkarguenaga, Beatriz Gonzalez-Valle, Ana Lain, Arantza Sanz-Parra, Oscar Coltell, Ander Lopez de Letona, Manfred Spraul, Shelly C. Lu, Elisabetta Buguianesi, Nieves Embade, Quentin M. Anstee, Dolores Corella, Jose M. Mato, Oscar Millet
Summary: Metabolic syndrome (MetS) is a complex condition without a clear medical definition. This study used NMR metabolomics to analyze urine samples from a European cohort, revealing a unique molecular signature of MetS. The results showed that MetS progression is associated with specific changes in the urine metabolome, which can be used to identify individuals with MetS and provide insight into the transitional states between healthy individuals and MetS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Clinical Neurology
Zachary R. Wanner, Cormac G. Southam, Prachi Sanghavi, Naveenjyote S. Boora, Eric J. Paxman, Sean P. Dukelow, Brian W. Benson, Tony Montina, Gerlinde A. S. Metz, Chantel T. Debert
Summary: This study examined the metabolic changes post-sport-related concussion (SRC) through urine analysis, identifying specific metabolites associated with SRC and suggesting a more objective method for characterizing the condition. The correlations found between specific metabolites and factors like symptom burden and length of return an potential applications as biomarkers for SRC diagnosis and treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
James Gerard Wolfsberger, Emily C. Hunt, Sai Sumedha Bobba, Sharifa Love-Rutledge, Bernhard Vogler
Summary: This study describes a pre-acquisition method of urine normalization, which adjusts for differences in the hydration state of each organism and results in a narrower concentration range in a targeted analysis.
Review
Biochemistry & Molecular Biology
Jesus Brezmes, Maria Llambrich, Raquel Cumeras, Josep Guma
Summary: Metabolomics is a crucial method for discovering novel biomarkers and their application in precision medicine. NMR-based metabolomics in urine can serve as a powerful clinical tool in precision oncology. This review provides a comprehensive evaluation of NMR metabolomics for the detection of colorectal cancer (CRC) in urine, identifying potential relevant compounds and metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Guanghui Xu, Xiaolong Lin, Yong Yu
Summary: Heavy metals in soil ecosystems pose a potential threat to soil biota. Micro-and nano-plastics (MNPs) can impact the accumulation of heavy metals in plants by altering soil microbial community and causing injury to plants. This study investigated the effects and mechanisms of MNPs on the uptake of Cu, Zn, Pb, and Cd in lettuce. The results showed that MNPs increased the uptake of heavy metals in lettuce by altering the relative abundance of key metal-activation bacteria in rhizospheric soil. The concentrations of heavy metals in nanoparticle treatments were significantly higher than that of microparticle treatments, particularly at higher nanoparticle concentration. Biomarkers and gene expression showed that high concentrations of nanoparticles caused more severe injuries to lettuce plants. Metabolomic analysis revealed that nanoparticles disturbed the metabolism of ATP-binding cassette transporter and plant hormone signal transduction in lettuce roots, leading to increased uptake of heavy metals by lettuce.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Aurang Zeb, Weitao Liu, Nouman Ali, Ruiying Shi, Yuhang Lian, Qi Wang, Jianling Wang, Jiantao Li, Zeqi Zheng, Jinzheng Liu, Miao Yu, Jianv Liu
Summary: This study investigated the effects of tire wear particles (TWPs) on the growth and metabolism of mung bean plants and soil. Despite the accumulation of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in TWPs-treated soils, there was no significant impact on plant growth, indicating a degree of tolerance. However, TWPs exposure had significant effects on soil enzyme activities, plant metabolite profiles, and microbiota.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Renu Yadav, Gagandeep Singh, Anita Rani Santal, Nater Pal Singh
Summary: Soil and water pollution, rapid industrialization, contaminated irrigation-water, increased waste-production and surge in agricultural land leads to the accumulation of Heavy Metals (HM) with time. HM contamination has raised concern over the past years and new remediation strategies are required to deal with it. Phytoremediation is of great significance in the removal, decomposition and detoxification of hazardous metals from HM-contaminated sites. There is a need for further research and biotechnological efforts to enhance the effectiveness of phytoremediation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Leon Deutsch, Alexandros Sotiridis, Bostjan Murovec, Janez Plavec, Igor Mekjavic, Tadej Debevec, Blaz Stres
Summary: Physical inactivity is a global health problem associated with chronic diseases. This study explores the metabolic differences between physically active and inactive young males. The results show significant differences before and after training sessions, with trained individuals having distinct urine metabolomes. Interestingly, even a small amount of exercise can modify the resting urine metabolome of inactive individuals. Moreover, urine samples taken over consecutive mornings can effectively detect differences in lifestyle.
Article
Biochemistry & Molecular Biology
Kerti Ausmees, Nele Reimets, Indrek Reile
Summary: Parahydrogen hyperpolarization is a promising tool for sensitively enhancing NMR metabolomics, allowing for resolution and quantification of low-abundance metabolites. The reliable identification of analytes producing parahydrogen hyperpolarized NMR signals currently requires the addition of internal standards, which can be laborious. This study demonstrates that generating libraries of hyperpolarized analyte signals, similar to regular NMR metabolomics, can address this limitation.
Article
Materials Science, Ceramics
Yili Zeng, Nan Duan, Caiping Fu, Dejin Liao, Xiaolan Song, Shengming Jin, Kuixin Cui
Summary: Using tailings to prepare constructive materials is important for sustainable development of the mineral processing industry. This study explored the possibility of preparing tungsten tailing-based geopolymers. Various analyses were conducted to characterize the composition, bonding, microstructure, and properties of the geopolymers. Results showed that geopolymers with a mixture of tungsten tailings and metakaolin had good compressive strength and could immobilize heavy metals efficiently. This research provides a new idea for the utilization of tungsten tailings on a large scale.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Leon Deutsch, Tadej Debevec, Gregoire P. Millet, Damjan Osredkar, Simona Opara, Robert Sket, Bostjan Murovec, Minca Mramor, Janez Plavec, Blaz Stres
Summary: Preterm birth has a significant impact on child mortality, and preterm born adults have an increased risk of chronic diseases. This study explored the differences in metabolomes between preterm and full-term male participants during rest and exercise, as well as the overall differences in human gut-microbiomes. The findings revealed a complex set of microbiome-related metabolic biomarkers, indicating distinct host-microbiome interactions between the two groups.
Article
Chemistry, Analytical
Mengnan Ma, Xiong-Fei Pan, An Pan, Limiao Jiang
Summary: This study systematically investigated the effect of urine dilution on 1H NMR metabolic profiles and found that mild dilution can preserve high-abundance metabolites, reduce chemical shift variations, and increase signal separations. These findings are important for NMR-based metabolomics research and large-scale epidemiological studies with limited samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mengnan Ma, Xiong-Fei Pan, An Pan, Limiao Jiang
Summary: This study systematically investigated the effect of urine dilution on 1H NMR metabolic profiles. It found that mild dilution (e.g. 40%) of human urine can preserve high-abundance metabolites, reduce intersample chemical shift variations, and increase separations of overlapped signals. This improvement is applicable for NMR-based metabolomics studies with limited urine volumes, including large-scale epidemiological studies.
ANALYTICAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Vibhor V. Borkar, Ujjal Poddar, Niraj Kumari, Suruchi Singh, Raja Roy, Surender K. Yachha
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2015)
Article
Biochemistry & Molecular Biology
Anil Bhatia, Santosh K. Bharti, Tusha Tripathi, Anuradha Mishra, Om P. Sidhu, Raja Roy, Chandra Shekhar Nautiyal
Article
Chemistry, Analytical
Anil Bhatia, Baleshwar Meena, Sanjeev K. Shukla, Om P. Sidhu, Dalip K. Upreti, Anuradha Mishra, Raja Roy, Chandra Shekhar Nautiyal
ANALYTICAL LETTERS
(2017)
Article
Medical Laboratory Technology
Suruchi Singh, Tanushri Chatterji, Manodeep Sen, Ishwar Ram Dhayal, Swati Mishra, Nuzhat Husain, Apul Goel, Raja Roy
CLINICA CHIMICA ACTA
(2016)
Review
Pharmacology & Pharmacy
Suruchi Singh, Raja Roy
EXPERT OPINION ON DRUG DISCOVERY
(2016)
Review
Biochemical Research Methods
Abdul-Hamid Emwas, Raja Roy, Ryan T. McKay, Danielle Ryan, Lorraine Brennan, Leonardo Tenori, Claudio Luchinat, Xin Gao, Ana Carolina Zeri, G. A. Nagana Gowda, Daniel Raftery, Christoph Steinbeck, Reza M. Salek, David S. Wishart
JOURNAL OF PROTEOME RESEARCH
(2016)
Article
Endocrinology & Metabolism
Tanushri Chatterji, Suruchi Singh, Manodeep Sen, Ajai Kumar Singh, Pradeep Kumar Maurya, Nuzhat Husain, Janmejai Kumar Srivastava, Sudhir Kumar Mandal, Raja Roy
Article
Biochemistry & Molecular Biology
Neeraj Rastogi, Nidhi Tyagi, Ovender Singh, B. S. Hemanth Kumar, Udai P. Singh, Kaushik Ghosh, Raja Roy
JOURNAL OF INORGANIC BIOCHEMISTRY
(2017)
Article
Endocrinology & Metabolism
Manvendra Pratap Singh, Mona Saxena, Charanjit S. Saimbi, Jamal M. Arif, Raja Roy
Article
Chemistry, Applied
Anil Bhatia, Tusha Tripathi, Suruchi Singh, Hema Bisht, Hari M. Behl, Raja Roy, Om P. Sidhu
NATURAL PRODUCT RESEARCH
(2019)
Review
Endocrinology & Metabolism
Abdul-Hamid Emwas, Claudio Luchinat, Paola Turano, Leonardo Tenori, Raja Roy, Reza M. Salek, Danielle Ryan, Jasmeen S. Merzaban, Rima Kaddurah-Daouk, Ana Carolina Zeri, G. A. Nagana Gowda, Daniel Raftery, Yulan Wang, Lorraine Brennan, David S. Wishart
Article
Endocrinology & Metabolism
Anup Paul, Surendra Kumar, Anubhav Raj, Abhinav A. Sonkar, Sudha Jain, Atin Singhai, Raja Roy
Review
Biochemistry & Molecular Biology
Abdul-Hamid Emwas, Raja Roy, Ryan T. McKay, Leonardo Tenori, Edoardo Saccenti, G. A. Nagana Gowda, Daniel Raftery, Fatimah Alahmari, Lukasz Jaremko, Mariusz Jaremko, David S. Wishart
Article
Endocrinology & Metabolism
Manvendra Pratap Singh, Mona Saxena, Charanjit S. Saimbi, Mohammed Haris Siddiqui, Raja Roy
Article
Medical Laboratory Technology
Tanushri Chatterji, Suruchi Singh, Manodeep Sen, Ajai Kumar Singh, Gaurav Raj Agarwal, Deepak Kumar Singh, Janmejai Kumar Srivastava, Alka Singh, Rajeshwar Nath Srivastava, Raja Roy
CLINICA CHIMICA ACTA
(2017)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)