Article
Cell Biology
Ravindra Gudneppanavar, Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Erik Southard, Ramakumar Tummala, Bina Joe, Charles K. Thodeti, Sailaja Paruchuri
Summary: Short-chain fatty acid butyrate, produced from bacterial fermentation of indigestible fiber in the intestine, can attenuate lung inflammation in asthma. Butyrate treatment modifies MC histones via butyrylation and acetylation, inhibits histone deacetylase (HDAC) activity, downregulates SCF receptor KIT and phosphorylation, leading to attenuation of MC proliferation and pro-inflammatory cytokine secretion. The mechanism involves the suppression of KIT, p38, and Erk phosphorylation, mediated by histone modification and HDAC1/3 inhibition. Butyrate supplementation could offer a potential treatment strategy for allergy and asthma through epigenetic alterations in MCs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Jiarui Zheng, Yao Lu, Jun Xiao, Yongjuan Duan, Suyu Zong, Xiaoli Chen, Tianyuan Hu, Long Li, Yingchi Zhang
Summary: Low nanomolar doses of pan-HDACi enhance IL2-induced NK cell proliferation without compromising cell function. The underlying mechanism involves upregulation of the JAK-STAT signaling pathway and enhancement of the cell cycle. In vivo experiments show that Dac treated NK cells maintain their tumor elimination capacity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Schioppa, Hoang Oanh Nguyen, Laura Tiberio, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Annalisa Del Prete, Daniela Bosisio, Valentina Salvi
Summary: This study investigated the effects of HDIs on TNFAIP3 expression and identified two distinct mechanisms of action: direct inhibition through HDAC blockade and indirect decrease via TNF-α induction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Qiang Wang, Zhiqiang Gao, Kai Guo, Jiawei Lu, Feng Wang, Yufeng Huang, Desheng Wu
Summary: This study investigated the changes in bone tissue signaling pathways associated with Enpp1 deficiency. The results showed that Enpp1 deletion downregulated the expression of the p38 MAPK signaling pathway in bones, and lysophosphatidic acid (LPA) partially rescued the proliferation of pre-osteoblasts via the MKK3/p38 MAPK/PCNA pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Cell Biology
Lingfan Xiong, Wenhao Guo, Yong Yang, Danping Gao, Jun Wang, Yuanyuan Qu, Ying Zhang
Summary: The study demonstrated that tectoridin (TEC) can inhibit proliferation, migration, and invasion of colon cancer cells, promote apoptosis, and suppress tumor growth in vivo. Furthermore, TEC exerts its anti-tumor effects by inhibiting the PKC/p38 MAPK pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Zhangming Chen, Zhe Jiang, Lei Meng, Ye Wang, Minggui Lin, Zhijian Wei, Wenxiu Han, Songcheng Ying, Aman Xu
Summary: SAMHD1 inhibits the proliferation of gastric cancer cells by negatively regulating the activation of MAPK p38 signaling pathway, and is upregulated by KLF4.
Article
Biochemistry & Molecular Biology
Xi Kuang, Shuang Chen, Jitong Lao, Yongmin Chen, Dandan Jia, Linzhi Tu, Lin Ma, Xiaoping Liao, Wenjie Zhao, Qifu Li
Summary: The study revealed that HDAC9 may mediate ox-LDL-induced inflammatory injury in vascular endothelial cells by regulating the phosphorylation level of P38 MAPK to lead to AS. The HDAC9 inhibitor sodium valproate (SVA) may be a potential drug for the prevention and treatment of ischemic stroke.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2021)
Article
Anatomy & Morphology
Ziyu Dai, Bin Xie, Baishuang Yang, Xi Chen, Chengping Hu, Qiong Chen
Summary: The study shows that KANK3 gene is down-regulated in lung adenocarcinoma tissues, and its expression level is closely related to the prognosis of lung adenocarcinoma patients. Overexpression of KANK3 significantly inhibits the proliferation, invasion, and migration ability of lung adenocarcinoma cells, while silencing of KANK3 enhances these abilities. Further experiments prove that KANK3 regulates the proliferation and metastasis of lung adenocarcinoma cells through the p38 MAPK signaling pathway.
Article
Agriculture, Dairy & Animal Science
Haorong He, Huadong Yin, Xueke Yu, Yao Zhang, Menggen Ma, Diyan Li, Qing Zhu
Summary: This study demonstrated that PDLIM5 can promote proliferation and differentiation of chicken skeletal muscle satellite cells through the p38-MAPK pathway. These findings suggest that PDLIM5 may play a role in the growth and development of chicken skeletal muscle.
Article
Oncology
Jiayang Cai, Lun Gao, Yixuan Wang, Yong Li, Zhang Ye, Shiao Tong, Tengfeng Yan, Qian Sun, Yang Xu, Hongxiang Jiang, Si Zhang, Linyao Zhao, Ji'an Yang, Qianxue Chen
Summary: Glioblastoma multiforme (GBM) is a common and fatal brain tumor. This study identified a new molecular mechanism, TMBIM1, which promotes cell proliferation and attenuates cell apoptosis in GBM by interfering with the p38/MAPK pathway.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Manchun Su, Huibin Shi, Xinming Duan, Youji Ma
Summary: This study demonstrates that the miR-1285-3p/TPI1 axis regulates glycolysis in Sertoli cells (SCs), providing new insights into the regulation of spermatogenesis in sheep and other mammals.
Article
Oncology
Hong Chen, Liju Tao, Juhua Liang, Chunfeng Pan, Hua Wei
Summary: Ubiquitin D (UBD), highly expressed in rheumatoid arthritis (RA), activates p38 MAPK signaling pathway to promote the proliferation of RA synoviocytes and secretion of inflammatory factors, facilitating the progression of RA. UBD may serve as a potential therapeutic target and prognostic biomarker for RA.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Cell Biology
Qun-Guang Jiang, Cheng-Feng Xiong, Yun-Xia Lv
Summary: Kin17 is significantly upregulated in thyroid cancer, where it functions as an oncogene by activating the p38 MAPK signaling pathway to promote cell proliferation, migration, and invasion, while also affecting the sensitivity of cancer cells to Doxorubicin.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Mengya Li, Yu Liu, Yajun Liu, Lu Yang, Yan Xu, Weiqiong Wang, Zhongxing Jiang, Yanfang Liu, Shujuan Wang, Chong Wang
Summary: The study found that GNA15 was highly expressed in adult AML, and high GNA15 expression was associated with lower overall survival and relapse-free survival in adult AML with normal karyotype. The inhibition of cell proliferation mediated by GNA15 knockdown may be regulated through the P38 MAPK signaling pathway, suggesting GNA15 as a potential prognostic marker and therapeutic target for AML in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Tang, Yongjuan Sun, Yingrui Li, Shuhua Ma, Kai Zhang, Ailing Chen, Yipin Lyu, Renqiang Yu
Summary: This study found differences in mitochondrial redox homeostasis and energy metabolism in tissues between obesity-prone and obesity-resistant rats. Sodium butyrate effectively promotes muscle protein synthesis, increases insulin sensitivity, and promotes glucose metabolism in obesity rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sabbir Khan, Sandeep Mittal, Kain McGee, Kristin D. Alfaro-Munoz, Nazanin Majd, Veerakumar Balasubramaniyan, John F. de Groot
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Jayant Patwa, Sabbir Khan, Gopabandhu Jena
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Chander K. Negi, Sabbir Khan, Hubert Dirven, Lola Bajard, Ludek Blaha
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global concern affecting 25% of the population, with risk factors including environmental toxicants. Environmental contaminants like flame retardants (FRs) may impact the immune and inflammatory signaling pathways of NAFLD, contributing to disease progression. Further research on pharmacotherapeutic molecules targeting these pathways is needed to address knowledge gaps in NAFLD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sabbir Khan, Rajasekaran Mahalingam, Shayak Sen, Emmanuel Martinez-Ledesma, Arshad Khan, Kaitlin Gandy, Frederick F. Lang, Erik P. Sulman, Kristin D. Alfaro-Munoz, Nazanin K. Majd, Veerakumar Balasubramaniyan, John F. de Groot
Summary: Interferon signaling plays a crucial role in glioma tumorigenesis, with high IFN/STAT1 signaling associated with poor survival outcomes and mesenchymal phenotype in patients. Targeting IFN signaling may be beneficial for a specific subgroup of GBM patients, with IFN-beta showing promise as a potential adjuvant therapy.
Article
Oncology
Jie Ding, Xiaolong Li, Sabbir Khan, Chen Zhang, Feng Gao, Shayak Sen, Amanda R. Wasylishen, Yang Zhao, Guillermina Lozano, Dimpy Koul, W. K. Alfred Yung
Summary: This study demonstrates that EGFR signaling inhibits wt-p53 function in GBM by promoting an interaction between p53 and DNA-PKcs.
Review
Biochemistry & Molecular Biology
Harsh Vardhan Charan, Durgesh Kumar Dwivedi, Sabbir Khan, Gopabandhu Jena
Summary: Liver injury induces an inflammatory response, leading to the activation of hepatic stellate cells (HSCs) that secrete ECM proteins and promote liver fibrosis. Inflammasomes, which are cytoplasmic protein complexes, mediate exaggerated inflammatory immune responses and contribute to chronic liver diseases. They recognize microbial motifs and damage-associated molecular patterns, leading to the production of active cytokines. This review provides a comprehensive summary of the role of NLRP3 inflammasome in liver fibrosis and discusses potential strategies for inhibiting its activation and downstream signaling.
Meeting Abstract
Oncology
Sabbir Khan, Emmanuel Martinez-Ledesma, Soon Young Park, Jianwen Dong, Yuji Piao, Erin Harrison, Dimpy Koul, Veerakumar Balasubramaniyan, John De Groot, W. K. Alfred Yung
Meeting Abstract
Oncology
Dimpy Koul, Shaofang Wu, Xaolong Li, Sabbir Khan, Veerakumar Balasubramaniyan, W. K. Alfred Yung
Meeting Abstract
Oncology
Sabbir Khan, Rajasekaran Mahalingam, Shayak Sen, Kaitlin Gandy, Kristin Alfaro-Munoz, Nazanin Majd, Veerakumar Balasubramaniyan, John DeGroot
Meeting Abstract
Oncology
Dimpy Koul, Veerakumar Balasubramaniyan, Xiaolong Li, Sabbir Khan, Davide Guggi, Thomas Mehrling, John DeGroot
Article
Oncology
Soon Young Park, Sandeep Mittal, Jianwen Dong, Kangjin Jeong, Emmanuel Martinez-Ledesma, Yuji Piao, Sabbir Khan, Verlene Henry, Roel G. W. Verhaak, Nazanin Majd, Veerakumar Balasubramaniyan, John F. de Groot
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Meeting Abstract
Oncology
Sabbir Khan, Yuji Piao, Sandeep Mittal, Kain McGee, Soon Park, Kristin Alfaro-Munoz, Veerakumar Balasubramaniyan, John DeGroot
Meeting Abstract
Oncology
Sandeep Mittal, Shayak Sengupta, Sabbir Khan, Kain McGee, Kristin Alfaro-Munoz, Veerakumar Balasubramaniyan, John DeGroot
Meeting Abstract
Oncology
Veerakumar Balasubramaniyan, Soon Park, Yuji Piao, Emmanuel Martinez, Jianwen Dong, Sandeep Mittal, Sabbir Khan, Ze-yan Zhang, Erik Sulman, John DeGroot
Meeting Abstract
Oncology
Soon Young Park, Yuji Piao, Emmanuel Martinez-Ledesma, Jianwen Dong, Sabbir Khan, Sandeep Mittal, Ze-yan Zhang, Erik P. Sulman, Veerakumar Balasubramaniyan, John F. de Groot
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)