期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 220, 期 -, 页码 169-180出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2014.06.024
关键词
Carbocysteine; Silver; Complex; Immunity; Oxidative stress; Nano-structure
A new silver-carbocysteine (Ccy-Ag) complex [Ag-2(Ccy)(2)(H2O)(2)] has been synthesized and characterized by using a combination of FTIR, Raman, molar conductivity, H-1 NMR, electronic spectra, thermal analyses, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The infrared spectrum of Ccy-Ag complex in comparison with carbocysteine ligand prove that Ccy behaves as monobasic bidentate chelate to the silver metal ions via the deprotonated carboxylate O atom. The assessments of Ccy and its complexation with Ag+ in treating COPD, evaluating immune activities through measuring IL-8, TGF-beta 1, VEGF and TNF-alpha, antioxidant activities of (Ccy-Ag) complex by measuring SOD, MDA and GPX and bronchial asthma were discussed. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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