Article
Environmental Sciences
Ji-Hoon Oh, Soon-Il An, Jongsoo Shin, Jong-Seong Kug
Summary: This study demonstrates the importance of the initial buoyancy states of the Arctic Ocean in determining the recovery of Arctic and global temperatures. It suggests that denser Arctic water and faster recovery of the Atlantic meridional overturning circulation are linked to delayed Arctic temperature recovery.
News Item
Multidisciplinary Sciences
Alexandra Witze
Summary: A team has detected a significant increase in lightning strikes in the Arctic, potentially linked to climate change, but others are unable to confirm these findings at this time.
Article
Meteorology & Atmospheric Sciences
Xiaodan Chen, Aiguo Dai
Summary: Under the influence of increasing greenhouse gases, the Arctic warms at a faster rate compared to other regions, known as Arctic amplification. It is found that the impact of increased CO2 on meridional wind (upsilon) is more significant than the effect of Arctic amplification alone, especially in the northern extratropics. The changes in upsilon are associated with variations in zonal temperature gradients caused by CO2 forcing. Furthermore, the study reveals that both CO2 forcing and Arctic amplification affect the climatology of northerlies over different regions, leading to complex responses in zonal temperature gradients and upsilon.
JOURNAL OF CLIMATE
(2022)
Article
Environmental Sciences
Leila dos Santos Machado, Fabiane Dorr, Felipe Augusto Dorr, Daniele Frascareli, Darllene S. Melo, Erik S. J. Gontijo, Kurt Friese, Ernani Pinto, Andre Henrique Rosa, Marcelo M. Pompeo, Viviane Moschini-Carlos
Summary: Toxic cyanobacteria blooms are a common issue in subtropical reservoirs and freshwater systems. This study investigated the presence of potentially toxic cyanobacteria and the environmental conditions associated with cyanotoxins in a Brazilian subtropical reservoir. Raphidiopsis raciborskii was found to be permanently present in the reservoir, with significant impact on the levels of Saxitoxin (STX) and Microcystin (MC). The study also revealed the sensitivity of R. raciborskii to thermal stratification and the potential production of STX under growth-restricting conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Vanessa M. M. Lopes, Melanie Court, Martim Costa Seco, Francisco O. O. Borges, Bernardo Vicente, Sandra Lage, Ana Catarina Braga, Bernardo Duarte, Catarina Frazao Santos, Ana Amorim, Pedro Reis Costa, Rui Rosa
Summary: Marine heatwaves (MHWs) have doubled in frequency since the 1980s and are projected to be exacerbated during this century. MHWs have been shown to trigger harmful algal blooms (HABs) and this study investigates the impact of MHWs on key parameters of the paralytic shellfish toxin (PST) producer Gymnodinium catenatum. The results suggest that MHWs can reduce the toxicity and production of PST compounds in G. catenatum.
Article
Environmental Sciences
Justin Rorar, Laura Davila Garcia, Teresa Cutright
Summary: This study investigated the removal efficiency of cyanotoxins by powdered activated carbon (PAC) and found that higher PAC doses led to higher cyanotoxin removals. It was also demonstrated that PAC can effectively remove multiple cyanotoxins in water with pH values between 6 and 9.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Meteorology & Atmospheric Sciences
Lin Zhang, Minghu Ding, Tingfeng Dou, Yi Huang, Junmei Lv, Cunde Xiao
Summary: This study projected changes in Arctic inversion depth in the mid-twenty-first century, finding a significant decrease in autumn and a slight decrease in winter. The shallowing of the inversion was most pronounced over the Arctic Ocean, with the largest decrease in the Pacific sector in autumn. The area where the inversion shallows is consistent with the area where sea ice is retreating.
JOURNAL OF CLIMATE
(2021)
Article
Environmental Sciences
Nima Madani, Nicholas C. Parazoo, Charles E. Miller
Summary: Remote sensing and site-level observations have revealed significant changes in Arctic ecosystems due to climate warming, including vegetation greening, changes in species composition, and alterations in phenology. In this study, the solar induced chlorophyll fluorescence (SIF) was used to examine the phenological changes in Arctic ecosystems from 2000 to 2020. The results showed distinct regional trends in the response of ecosystems to climate change, influencing the timing of spring photosynthesis onset, peak productivity during the growing season, and fall senescence. The findings highlight the importance of biodiversity and phenology information in Arctic ecosystem models and projections for better understanding the impacts of climate change.
ENVIRONMENTAL RESEARCH LETTERS
(2023)
Review
Environmental Sciences
Michael Previdi, Karen L. Smith, Lorenzo M. Polvani
Summary: Arctic amplification (AA) is a prominent feature of climate change, mainly caused by local feedbacks and changes in energy transport. The feedbacks and energy transport changes are highly dependent on the climate system state, with significant implications for past and future climate change.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Engineering, Environmental
Victoria G. Christensen, Erin A. Stelzer, Barbara C. Eikenberry, Hayley T. Olds, Jaime F. LeDuc, Ryan P. Maki, Alisha M. Saley, Jack Norland, Eakalak Khan
Summary: This study compared cyanotoxin mixture models to microcystin models, finding that comprehensive models explained more variability. The research demonstrated that cyanotoxin mixture models were able to simulate observations exceeding regulatory guidelines.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Noor Redha Gummaa, Ahmed Sahi Dwaish, Israa Hussein Hamzah
Summary: The study aimed to detect genes associated with cylindrospermopsin and saxitoxin biosynthesis in river water using PCR technology, successfully identifying cyanobacteria species capable of producing these toxins. This early detection method is valuable for water treatment facilities responsible for providing safe drinking water to the public.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Environmental Sciences
David B. Bonan, Flavio Lehner, Marika M. Holland
Summary: Improved understanding of the sources of uncertainty in Arctic sea ice projections is crucial for assessing the impacts of changing Arctic environment. This study finds that internal variability, model structure, and emissions scenario all play significant roles in predicting Arctic sea-ice area. Internal variability has a larger impact on uncertainty in the short term, while emissions scenario becomes dominant over longer time scales. Additionally, there is a considerable dependency of model uncertainty on the season, with larger uncertainties in winter months.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Economics
Francis X. Diebold, Glenn D. Rudebusch
Summary: The study found that Arctic sea ice has been steadily decreasing as atmospheric greenhouse gas concentrations increase. Using observed data from 1979 to 2019, the researchers discovered a close linear relationship between Arctic sea ice area and cumulative carbon dioxide emissions. The sensitivity of Arctic sea ice area to carbon emissions is much stronger in observed data compared to climate models. This suggests that an ice-free Arctic may occur earlier than projected by current climate models for a given future emissions path. Additionally, there has been limited progress in accurately matching the observed carbon-climate response of Arctic sea ice in recent global climate modeling.
Article
Geosciences, Multidisciplinary
J. K. Ridley, E. W. Blockley, M. A. Ringer
Summary: The study investigates the impact of declining sea ice on Arctic water vapor using a climate model. It shows that the changes in water vapor are influenced by both local evaporation and transport from mid-latitudes. The study also reveals distinct patterns in water vapor change, with sea ice loss affecting evaporation except in summer when transports dominate.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Geosciences, Multidisciplinary
Matthew Jenkins, Aiguo Dai
Summary: Arctic amplification, the enhanced Arctic warming, is mainly attributed to intensified winter oceanic heating associated with sea-ice loss, aided by positive surface albedo feedback in summer and positive cloud feedback in winter.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Plant Sciences
Jonathan Puddick, Georgia Thomson-Laing, Susanna A. Wood
NEW ZEALAND JOURNAL OF BOTANY
(2019)
Article
Chemistry, Organic
J. Sam Murray, Andrew Selwood, D. Tim Harwood, Roel van Ginkel, Jonathan Puddick, Lesley L. Rhodes, Frode Rise, Alistair L. Wilkins
TETRAHEDRON LETTERS
(2019)
Article
Fisheries
Matthew R. Miller, Jonathan Puddick, Jane E. Symonds, Seumas P. Walker, Hong (Sabrina) Tian
AQUACULTURE RESEARCH
(2019)
Article
Fisheries
Vanessa Cotterill, David P. Hamilton, Jonathan Puddick, Alastair Suren, Susanna A. Wood
NEW ZEALAND JOURNAL OF MARINE AND FRESHWATER RESEARCH
(2019)
Article
Multidisciplinary Sciences
Laura T. Kelly, Keith Bouma-Gregson, Jonathan Puddick, Rich Fadness, Ken G. Ryan, Timothy W. Davis, Susanna A. Wood
Article
Food Science & Technology
Nataliia Khomutovska, Malgorzata Sandzewicz, Lukasz Lach, Malgorzata Suska-Malawska, Monika Chmielewska, Hanna Mazur-Marzec, Marta Ceglowska, Toirbek Niyatbekov, Susanna A. Wood, Jonathan Puddick, Jan Kwiatowski, Iwona Jasser
Article
Environmental Sciences
Jonathan Puddick, Roel van Ginkel, Carrie D. Page, J. Sam Murray, Hannah E. Greenhough, Joel Bowater, Andrew Selwood, Susanna A. Wood, Michele R. Prinsep, Penelope Truman, Rex Munday, Sarah C. Finch
Summary: Microcoleus autumnalis, a cyanobacterium growing in rivers, produces high concentrations of the neurotoxin dhATX, which has demonstrated high acute toxicity upon ingestion. Further research is needed to assess the environmental impact and health risks associated with this cyanobacterial species.
Article
Food Science & Technology
Barbara Weisbrod, Susanna A. Wood, Konstanze Steiner, Ruby Whyte-Wilding, Jonathan Puddick, Olivier Laroche, Daniel R. Dietrich
Article
Food Science & Technology
J. Sam Murray, Sarah C. Finch, Jonathan Puddick, Lesley L. Rhodes, D. Tim Harwood, Roel van Ginkel, Michele R. Prinsep
Summary: The study isolated a sulphated cyclic polyether, gambierone, and evaluated its toxicity, showing low toxicity and unlikely involvement in ciguatera poisoning. Analysis of the production of gambierone and 44-methylgambierone by multiple benthic dinoflagellate species revealed that only two species produced higher levels of gambierone.
Article
Multidisciplinary Sciences
Susanna A. Wood, Jonathan Puddick, Ian Hawes, Konstanze Steiner, Daniel R. Dietrich, David P. Hamilton
Summary: This study found a strong positive correlation between Microcystis cell concentrations and microcystin quotas in waterbodies, indicating that higher cell densities can increase bloom toxicity potential. High-throughput sequencing analysis showed no relationship between microcystin quotas and the relative abundance of specific sequences.
Article
Microbiology
Mailys Picard, Susanna A. Wood, Xavier Pochon, Marcus J. Vandergoes, Lizette Reyes, Jamie D. Howarth, Ian Hawes, Jonathan Puddick
Summary: Understanding the historical onset of cyanobacterial blooms in freshwater bodies can help identify their potential drivers. Lake sediments are valuable archives for exploring these records. In this study, we compared the results obtained from a droplet digital PCR assay and high-performance liquid chromatography to analyze cyanobacterial DNA and pigments in sediment cores. Our findings suggest that the biphasic approach of combining these two methods can provide complementary information for studying changes in the cyanobacterial community.
Article
Energy & Fuels
Martin Spiller, Corinna Mueller, Zara Mulholland, Paraskevi Louizidou, Frithjof C. Kupper, Kevin Knosala, Peter Stenzel
Summary: Reducing carbon emissions from hotels on non-interconnected islands is crucial for a low carbon future in the Mediterranean region. Introducing a Photovoltaic (PV) net metering system can significantly reduce carbon emissions associated with these hotels' energy systems.
Article
Limnology
Lena A. Schallenberg, Susanna A. Wood, Jonathan Puddick, Pedro J. Cabello-Yeves, Carolyn W. Burns
Summary: This study isolated and characterized 25 monoclonal picocyanobacterial strains from lakes in New Zealand. The strains were identified as cluster 5 picocyanobacterial lineage, with some showing global dispersal. Pigment analysis revealed variations in pigment composition among strains from different trophic states. The obtained cultures will contribute to the study of the function and response of these important microbes to environmental changes.
Article
Chemistry, Medicinal
J. Sam Murray, Sarah C. Finch, Elizabeth M. Mudge, Alistair L. Wilkins, Jonathan Puddick, D. Tim Harwood, Lesley L. Rhodes, Roel van Ginkel, Frode Rise, Michele R. Prinsep
Summary: Identifying compounds responsible for toxicity in Gambierdiscus species is crucial in determining their role in ciguatera poisoning. Two new MTX analogs, MTX-6 and MTX-7, were isolated from G. cheloniae CAWD232 and G. honu CAWD242, respectively. This study provides the most extensive structural characterization of an MTX analog since the complete structure of MTX-1 in 1993.
Article
Marine & Freshwater Biology
Jonathan Puddick, Sebastian Naeher, John K. Pearman, Carrie D. Page, Donato Romanazzi, Lena A. Schallenberg, Jamie D. Howarth, Marcus J. Vandergoes, Susanna A. Wood
Summary: Cyanobacterial blooms are increasing globally, impacting lake ecosystems and posing a risk to human and animal health. Cyanobacterial pigments preserved in lake sediments can help understand the changes that have led to these blooms. By analyzing pigments in cyanobacteria cultures and applying the findings to lake sediments, we found that carotenoids can be used to evaluate cyanobacterial abundance and differentiate different cyanobacteria types. Ratios of specific carotenoids can be used as a proxy to evaluate historical shifts in cyanobacterial communities.
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)