Article
Biochemistry & Molecular Biology
Wei-Sheng Wu, Hsin-Yi Wu, Pin-Hsuan Wang, Ting-Yu Chen, Kuan-Ru Chen, Chih-Wei Chang, Dong-En Lee, Bo-Heng Lin, William Chih-Wei Chang, Pao-Chi Liao
Summary: Lung cancer is a major cause of cancer-related death worldwide, and research is needed to dissect its pathogenic mechanisms and discover specific biomarkers. LCMD is the first database to provide information on lung cancer-related metabolites, aiming to promote the discovery of biomarkers for lung cancer.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Julia Lesko, Alexander Triebl, Elvira Stacher-Priehse, Nicole Fink-Neuboeck, Joerg Lindenmann, Freyja-Maria Smolle-Juettner, Harald C. Koefeler, Andelko Hrzenjak, Horst Olschewski, Katharina Leithner
Summary: This study investigates the dynamics of phospholipids in lung cancer tissue by analyzing de novo biosynthesis of glycerophospholipids using stable isotopic labeling. The results suggest increased turnover of PE in lung cancer tissue compared to normal lung tissue, supported by enhanced expression of PE biosynthesis genes and decreased expression of PC and PI biosynthesis genes. These findings provide insights into metabolic alterations in lung cancer and suggest potential targets for therapeutic intervention.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Caterina Bartolacci, Cristina Andreani, Goncalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald, Pier Paolo Scaglioni
Summary: Mutant KRAS is associated with poor prognosis in lung cancer and promotes lipid metabolism. This study reveals that fatty acid synthesis is crucial for the viability of mutant KRAS lung cancer cells. Blocking fatty acid synthesis or the Lands cycle promotes ferroptosis, a type of cell death characterized by the accumulation of oxidation-prone phospholipids. Mutant KRAS makes lung cancer cells more reliant on newly synthesized fatty acids.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Wen Lin, Yuping Chen, Yang Su, Xiaopin Lai, Kunbin Guo, Xin Wang, Siyu Chen, Kaiqing Liang, Keyuan Pu, Yue Wang, Jun Hu, Xiaolong Wei, Hongbiao Wang, Wenxiu Ni, Yan Lin, Janshon Zhu, Kwan-Ming Ng
Summary: This research successfully fabricated a covalently bonded AuNPs array for analyzing small biomolecules in human serum in high-salt environments. The covalently bonded array showed superior performances in stability, reproducibility, and sensitivity compared to the self-assembled array. Furthermore, the closely positioned AuNPs generated an enhanced electric field, thereby enhancing the detection sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Monica Sheinin, Brian Jeong, Ramesh K. Paidi, Kalipada Pahan
Summary: This study highlights the importance of SARS-CoV-2 spike S1 protein in inducing death in lung cancer cells and reducing tumor growth in mice. The findings suggest that intranasal treatment with recombinant SARS-CoV-2 spike S1 protein could be a beneficial option for lung cancer patients.
Article
Biochemical Research Methods
Linling Guo, Linrui Li, Zhiyun Xu, Fanchen Meng, Huimin Guo, Peijia Liu, Peifang Liu, Yuan Tian, Fengguo Xu, Zunjian Zhang, Shuai Zhang, Yin Huang
Summary: Metabolic markers play important roles in diagnosing and treating cancers, but effective markers are limited by the lack of metabolite selection approaches. In this study, a network-based strategy was proposed to uncover metabolic markers for NSCLC using mass spectrometry-based metabolomics and KEGG database. By identifying 23 putative metabolic markers related to NSCLC, this study also found potential molecular targets and a panel of eight strong candidate metabolites for NSCLC diagnosis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiaotong Luo, Yuantai Huang, Huiqin Li, Yihai Luo, Zhixiang Zuo, Jian Ren, Yubin Xie
Summary: The SPENCER database compiles research on ncRNA-encoded small peptides in cancer, identifying 29,526 ncPEPs across 15 different cancer types. Of these, 22,060 have been experimentally validated. Additionally, SPENCER predicted the immunogenicity of 4497 ncPEPs, making it a valuable resource for cancer research.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Elina Gashimova, Azamat Temerdashev, Vladimir Porkhanov, Igor Polyakov, Dmitry Perunov, Ekaterina Dmitrieva
Summary: Development of simple, fast, and non-invasive tests for lung cancer diagnostics is crucial in clinical practice. This paper explores the use of exhaled breath and skin as potential objects for diagnosing lung cancer, and develops diagnostic models using machine learning algorithms. The results show that artificial neural networks perform well in classifying lung cancer patients and healthy individuals. Additionally, the study identifies significant differences in parameters in exhaled breath samples of lung cancer patients and evaluates the potential of skin analysis for lung cancer diagnosis.
Article
Multidisciplinary Sciences
Jiazhen Zhou, Xinchao Guan, Enwu Xu, Jiaxin Zhou, Rui Xiong, Qiaoyuan Yang
Summary: In this study, the high expression of chimeric RNA RRM2-C2orf48 was found to be significantly correlated with lymph node metastasis, distant metastasis, TNM stage, and smoking in lung cancer patients and cell lines. Overexpressing RRM2-C2orf48 promoted cell growth and accelerated the NNK-induced lung cancer process. The knockdown of RRM2-C2orf48 inhibited the growth of RRM2-C2orf48-overexpressing cells, and miR-219a-2-3p was identified as a potential target of RRM2-C2orf48 in lung cancer.
Article
Biochemistry & Molecular Biology
Kevin P. Gillespie, Ross Pirnie, Clementina Mesaros, Ian A. Blair
Summary: It has been found that cisplatin treatment can induce secretion of HMGB1 from human non-small cell lung cancer cells, while carboplatin cannot. This secretion is dose-dependent and regulated by nuclear exportin 1. Additionally, the secreted HMGB1 after cisplatin treatment is mainly in the fully reduced form.
Article
Oncology
Yanhong Liu, Lan Gao, Yanru Fan, Rufei Ma, Yunxia An, Guanghui Chen, Yan Xie
Summary: Potential protein biomarkers and mechanism of venous thromboembolism (VTE) in non-small cell lung cancer (NSCLC) patients were identified through proteomics research. A total of 280 differentially expressed proteins were found, and 5 proteins (SAA1, S100A8, LBP, HP and LDHB) showed significant changes between VTE and non-VTE patients. These results suggest that these proteins may be used for diagnosing VTE in NSCLC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Belen Callejon-Leblic, Saida Sanchez Espirilla, Carolina Gotera-Rivera, Rafael Santana, Isabel Diaz-Olivares, Jose M. Marin, Ciro Casanova Macario, Borja Garcia Cosio, Antonia Fuster, Ingrid Solanes Garcia, Juan P. de-Torres, Nuria Feu Collado, Carlos Cabrera Lopez, Carlos Amado Diago, Amparo Romero Plaza, Luis Alejandro Padron Fraysse, Eduardo Marquez Martin, Margarita Marin Royo, Eva Balcells Vilarnau, Antonia Llunell Casanovas, Cristina Martinez Gonzalez, Juan Bautista Galdiz Iturri, Celia Lacarcel Bautista, Jose Luis Gomez-Ariza, Antonio Pereira-Vega, Luis Seijo, Jose Luis Lopez-Campos, German Peces-Barba, Tamara Garcia-Barrera
Summary: This study found that the severity of chronic obstructive pulmonary disease (COPD) and lung cancer (LC) significantly impact the elemental composition of human serum. These findings may pave the way for the potential use of elements as biomarkers for the diagnosis and prognosis of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eva Cifkova, Radana Brumarova, Magdalena Ovcacikova, Dana Dobesova, Katerina Micova, Ales Kvasnicka, Zuzana Vankova, Jiri Siller, Lukas Sakra, David Friedecky, Michal Holcapek
Summary: The study conducted lipidomic and metabolomic analysis on tumor and surrounding normal tissues of 23 patients with non-small cell lung cancer, identifying and quantifying 500 molecular species. Significant changes were observed in several biochemical pathways related to lung cancer, particularly involving glycerophospholipids, sphingolipids, and cholesteryl esters in lipid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Oncology
Ayse Ece Gulen, Rakesh Rudraboina, Mohammad Tarique, Vahap Ulker, Haval Shirwan, Esma S. S. Yolcu
Summary: Immunotherapy utilizing checkpoint inhibitors has shown remarkable success in cancer treatment. This study investigates the potential of using a specific immune co-stimulatory receptor, CD137, to enhance immune activation and inhibit tumor growth. The researchers generated a soluble form of the CD137 ligand, which effectively inhibited the development of lung tumors in mice induced by a tobacco carcinogen. The study suggests that this immune co-stimulation approach can be extended to other cancer types.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemical Research Methods
Mohd Altaf Najar, Prashant Kumar Modi, Poornima Ramesh, David Sidransky, Harsha Gowda, T. S. Keshava Prasad, Aditi Chatterjee
Summary: CAMKK2 is highly expressed in gastric cancer and promotes tumor progression. Inhibiting CAMKK2 can reduce the migration, invasion, and proliferation abilities of gastric cancer cells. Quantitative proteomic analysis identified several key proteins involved in cell division and proliferation that were downregulated upon CAMKK2 inhibition, suggesting CAMKK2 as a potential therapeutic target in gastric cancer.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Medicine, Research & Experimental
Gunjan Sharma, Md. Umama Ashhar, Vidhu Aeri, Deepshikha Pande Katare
Article
Biochemistry & Molecular Biology
Kanagarethinam Selvaraj, Deepshikha Pande Katare, Prabhanshu Kumar, Nidhee Chaudhary
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Neurosciences
Nitu Dogra, Ruchi Jakhmola Mani, Deepshikha Pande Katare
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2020)
Article
Neurosciences
Ruchi Jakhmola-Mani, Anam Islam, Deepshikha Pande Katare
Summary: The study investigates the impact of junk food on the liver-brain axis and the protein connections leading to neurodegenerative disorders, highlighting the crucial role of specific genes in impairing liver and brain health.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Review
Cell Biology
Nitu Dogra, Ruchi Jakhmola Mani, Deepshikha Pande Katare
Summary: Parkinson's disease is a chronic and progressive neurological disorder involving the motor system, with its pathogenesis closely related to the gut microbiome and the gut-brain axis, which may influence the disease progression through various mechanisms. Understanding the interaction between the gut-brain axis, gut microbiota, and Parkinson's disease is crucial for the development of novel therapeutic and diagnostic approaches.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kanagarethinam Selvaraj, Deepshikha Pande Katare, Subhash Chand, Nidhee Chaudhary
Summary: Nutraceuticals like Trachyspermum ammi and Cinnamomum verum contain potent Protein Tyrosine Phosphatases (PTPases) that play crucial roles in cell signal transduction and development, making them potential pharmacological targets. These PTPases also exhibit thermal stability and sensitivity to certain ions, indicating their industrial relevance and potential therapeutic applications.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Uoorakkottil Ilyas, Deepshikha P. Katare, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Muhammed Elayadeth-Meethal, Vidhu Aeri
Summary: This study evaluated the immunomodulatory activity of Phyllanthus species and found that the ethyl acetate fraction had a significant stimulatory effect on NO production by macrophages. The fraction contained high amounts of polyphenols, which were responsible for immunomodulation. The polyphenols exhibited both inhibitory and stimulatory effects on NO production at different concentrations.
Review
Neurosciences
Kritie Agarwal, Deepshikha Pande Katare, Ruchi Jakhmola-Mani
Summary: Alzheimer's Disease (AD) is a prevalent neurodegenerative disorder with no known cure. Drug repurposing has emerged as a promising approach for finding a treatment for AD, utilizing existing medications in innovative ways.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Anthropology
Jai Chand Patel, Apoorv Gupta, Prince Kumar, Kamran Manzoor Waidha, Aakash Deep, Ashish Kumar, Deepshikha Pande Katare, Arun K. K. Sharma
Summary: Seasonal changes in the human cardiovascular system have a significant impact on the onset of various diseases. Evaluating the etiological and seasonal sensitive patterns of cardiovascular diseases is crucial for the majority of the population.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Neurosciences
Ruchi Jakhmola Mani, Nitu Dogra, Deepshikha Pande Katare
Summary: Junk foods with low nutrients and high trans fats can cause liver and brain damage, including non-alcoholic fatty liver disease and memory impairment. A high intake of junk foods can lead to insulin resistance, affecting the liver's detoxification function and the brain's memory function.
Article
Chemistry, Applied
Kanagarethinam Selvaraj, Subhash Chand, Deepshikha Pande Katare, Nidhee Chaudhary
Summary: Functional foods have gained attention in the healthcare industry for their therapeutic potential. Dry fruit and nuts, such as Ribes nigrum and Juglans regia, have been identified as potential sources of bioactive ingredients with significant therapeutic potential.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ruchi Jakhmola Mani, Nikita Sehgal, Nitu Dogra, Shikha Saxena, Deepshikha Pande Katare
Summary: This study explores the potential use of Nigella sativa as a treatment for COVID-19. In-silico studies show that its bioactive constituents have similar pathways to the SARS-CoV-2 infection, and have a strong binding affinity to ACE2. The herb's phytoconstituents also play a role in various molecular pathways that can help combat hypoxia and inflammation caused by compromised immune system and oxidative stress.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Oncology
Sandhya Hora, Mohammad Asad, Swatantra Kumar Jain, Deepshikha Pande Katare
Summary: The study developed a stage-specific HCC rat model using diethylnitrosamine and thioacetamide (TAA) in Wistar rats, identifying promising stage-specific targets (EHMT2, GMPS, and SPRY2). Using high-throughput microarray data, EHMT2, GMPS, and SPRY were found to be high centrality nodes in protein-protein interaction studies, suggesting their potential role in signaling pathways of HCC.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Nitu Dogra, Dheeraj Nagpal, Vidhu Aeri, Saif Ahmad, Deepshikha Pande Katare
Summary: The combination of MP extract and SO can alleviate oxidative stress, significantly increase cholinergic enzyme activity and dopamine levels, thereby helping to prevent neuronal cell damage.
Article
Multidisciplinary Sciences
Oyesolape B. Oyelaja-Akinsipo, Enock O. Dare, Deepshikha P. Katare
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
