Review
Environmental Sciences
Shiv Bolan, Hasintha Wijesekara, Achali Ireshika, Tao Zhang, Mingjun Pu, Gianniantonio Petruzzelli, Francesca Pedron, Deyi Hou, Liuwei Wang, Sarah Zhou, Hoachen Zhao, Kadambot H. M. Siddique, Hailong Wang, Jorg Rinklebe, M. B. Kirkham, Nanthi Bolan
Summary: This review provides an overview of the current knowledge on tungsten pollution in complex environmental settings, including its behavior in soil and water, environmental and human health hazards, and remediation strategies. Tungsten is a rare element used in many alloys with wide industrial applications. However, tungsten alloys and their particles have been recently identified as potentially carcinogenic and harmful to animals and humans.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Chemistry, Multidisciplinary
Chenglu Gu, Zhiqiang Wang, Yawen Pan, Shuang Zhu, Zhanjun Gu
Summary: This study provides a comprehensive review and analysis of the application of tungsten-based nanomaterials (TNMs) in the biomedical field using bibliometric analysis. The study identifies research hotspots in various biomedical fields and provides a comprehensive review of these hotspots, including biological sensing, anticancer treatments, antibacterials, and toxicity evaluation. Finally, the prospects and challenges of TNMs are discussed.
ADVANCED MATERIALS
(2023)
Article
Geochemistry & Geophysics
Graham W. Lederer, Federico Solano, Joshua A. Coyan, Kevin M. Denton, Kathryn E. Watts, Celestine N. Mercer, Damon P. Bickerstaff, Matthew Granitto
Summary: The new quantitative mineral resource assessment focuses on the Great Basin region of western Nevada and eastern California, providing estimates of known and undiscovered tungsten resources. By integrating various data and analysis methods, the assessment contributes to understanding the economic significance and potential of tungsten resources in the region.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2021)
Article
Energy & Fuels
Kurt O. Kraal, Bridget F. Ayling, Kelly Blake, Logan Hackett, Tito Satria Putra Perdana, Robert Stacey
Summary: The study conducted detailed geological characterization of the Fallon FORGE EGS site in Nevada and deep drilling exploration, revealing the presence of natural fractures suitable for hydraulic stimulation.
Article
Environmental Sciences
Hsin Her Yu, Yi-Chun Chen, Han-Pang Su, Liliang Chen, Hung-Hsiang Chen, Kun-Yi Andrew Lin, Chia-Hua Lin
Summary: This study evaluated the toxic risk of tungsten trioxide (WO3) nanoparticles and explored their mechanism of toxicity. The results showed that these nanoparticles have cytotoxic effects on lung cells and are associated with an increased risk of developing chronic obstructive pulmonary disease.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Samy Selim, Hamada AbdElgawad, Ahmed Mohamed Reyad, Bassam F. Alowaiesh, Nashwa Hagagy, Mohammad M. Al-Sanea, Salam S. Alsharari, Mahmoud M. Y. Madany
Summary: Tungsten nanoparticles (WNPs) can have a hazardous impact on plant growth and development, but this study found that pre-inoculation with Nocardiopsis sp. can effectively mitigate the phytotoxicity of WNPs on wheat, barley, and oat crops by enhancing growth and reactive oxygen species (ROS) homeostasis, regulating antioxidant balance, and improving detoxification metabolism.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Oncology
Katherine Green, Sneha Tandon, Mansur Ahmed, Wanda Toscano, David O'Connor, Philip Ancliff, Ajay Vora, Jack Bartram, Sujith Samarasinghe, Sara Ghorashian, Vesna Pavasovic, Anupama Rao
Summary: Congenital Acute Myeloid leukemia (CAML) is a rare form of leukemia diagnosed in infants within the first 28 days of life. Treatment remains challenging with low survival rates, particularly due to treatment-related toxicities which need to be addressed.
LEUKEMIA & LYMPHOMA
(2021)
Article
Environmental Sciences
Mengjia Li, Fangyu Zhang, Shaojing Li, Xuexia Wang, Jun Liu, Bin Wang, Yibing Ma, Ningning Song
Summary: Increasing pH values can alleviate W(VI) toxicity on wheat, while the activities of H2PO4- and SO42- can also decrease toxicity. Competition from Cl- and NO3 - does not significantly influence W(VI) toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biophysics
Anju Surendranath
Summary: In this study, solvothermal liquid exfoliation method was used to synthesize bright green emissive WS2 QDs with excellent properties. The size and morphology were confirmed by HRTEM, and cytotoxicity analysis and radioactivity measurement showed biocompatibility and distribution of the QDs. ICP-MS analysis further confirmed the renal excretion route and lack of toxic response. This study proves that WS2 QDs are safe materials for biomedical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Elisa da Silva Menezes, Francisco Cezar Aquino de Moraes, Amanda de Nazare Cohen-Paes, Alayde Vieira Wanderley, Esdras Edgar Batista Pereira, Lucas Favacho Pastana, Antonio Andre Conde Modesto, Paulo Pimentel de Assumpcao, Rommel Mario Rodriguez Burbano, Sidney Emanuel Batista dos Santos, Ney Pereira Carneiro dos Santos, Marianne Rodrigues Fernandes
Summary: This study investigated the role of genetic variations in miRNA genes and genes encoding proteins of the miRNA synthesis complex (SC) in the treatment-related toxicities (TRTs) of acute lymphoblastic leukemia (ALL) patients. The findings revealed several SNVs associated with increased or decreased risk of developing different toxicities, such as neurological toxicity, gastrointestinal toxicity, infectious toxicity, and severe hematologic toxicity. The study suggests the potential use of these genetic variants to understand and predict the development of toxicities in ALL patients from the Brazilian Amazon region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Lorena Perez-Amill, Alex Bataller, Julio Delgado, Jordi Esteve, Manel Juan, Nela Klein-Gonzalez
Summary: This article provides guidance for the design, development, and clinical translation of CAR-T cell therapies for AML treatment. It discusses the considerations in designing these therapies, in vitro and in vivo assays to prove their efficacy and safety, and the expertise and facilities required for treating and managing patients in the hospital.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gabriela Burgueno-Rodriguez, Yessika Mendez, Natalia Olano, Magdalena Schelotto, Luis Castillo, Ana Maria Soler, Julio da Luz
Summary: This study aims to identify genetic variants related to drugs used in the treatment of pediatric acute lymphoblastic leukemia in Uruguay and analyze their contribution to adverse effects. The study found that mucositis, Cushing syndrome, and neurotoxicity were linked to specific genetic variants and individual genetic ancestry.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Akbar Padash, Rasoul Heydarnajad Giglou, Mousa Torabi Giglou, Rasoul Azarmi, Amir Mohammad Mokhtari, Gholamreza Gohari, Mojtaba Amini, Cristina Cruz, Mansour Ghorbanpour
Summary: The production and release of nanoparticles and their impacts on living organisms are a major global concern. Spirulina platensis was used to study the effects of a new type of nanoparticles, specifically vanadium oxide nanoparticles (VNPs) and tungsten oxide nanoparticles (WNPs). The concentrations of these nanoparticles had varying effects on protein and phycocyanin content, with VNPs showing toxic effects at higher concentrations, while WNPs increased protein and phycocyanin concentrations without toxic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Riitta Niinimaki, Henri Aarnivala, Joanna Banerjee, Tytti Pokka, Kaisa Vepsalainen, Arja Harila-Saari
Summary: This study aimed to investigate whether a shorter duration of FA rescue in the setting of rapid HD-MTX clearance is associated with increased toxicity. Results showed that one or two doses of FA following rapid MTX clearance resulted in a shorter inpatient time without an increase in toxic effects.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Naveed, Noor ul Ain, Tariq Aziz, Khushbakht Javed, Muhammad Aqib Shabbir, Metab Alharbi, Abdulrahman Alsahammari, Abdullah F. Alasmari
Summary: BCR-ABL1 is a fusion protein that is used as a clinical biomarker primarily for chronic myeloid leukemia (CML). This study explores the use of gamma-tocotrienol as a BCR-ABL1 inhibitor and utilizes deep learning artificial intelligence (AI) drug design to develop new drug compounds. The research shows that the AI-designed gamma-tocotrienol is effective and more hepatoprotective than the currently provided medications. However, further in vivo testing is needed for verification.
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)