期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 194, 期 1, 页码 23-30出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2011.08.001
关键词
Bisphenol-A; PC12 cell; MAPK; ERK; Neurite; Nerve growth factor
资金
- Japan Society for the Promotion of Science [20310017, 18590548, 22659120]
- Grants-in-Aid for Scientific Research [18590548, 23655139, 22659120, 20310017] Funding Source: KAKEN
An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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