Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Aaron B. Bowman, Michael Aschner
Summary: MeHg disrupts the physiological functions of ghrelin differently in males and females, enhancing ghrelin-induced body weight gain in males by activating the AMPK/UCP2 signaling pathway and mitigating ghrelin-induced weight gain in females by inhibiting mTOR signaling and decreasing Npy mRNA expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Toxicology
Selinay Basak Erdemli-Kose, Anil Yirun, Aylin Balci-Ozyurt, Pinar Erkekoglu
Summary: Short-chained alkyl mercury compounds accumulate in the brain, associated with various neurotoxic effects. Gender-based differences in neurodevelopmental disorders may be influenced by testosterone and estradiol altering the toxic effect of these compounds. The study found that both thimerosal and methylmercury are toxic to SH-SY5Y cells, with methylmercury showing more severe toxic effects.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Review
Neurosciences
Claire L. J. Bottini, Scott A. MacDougall-Shackleton
Summary: Methylmercury (MeHg) is a concerning contaminant due to its ubiquity and harmful effects on organisms. The literature on MeHg effects on the avian brain is limited, and the neural effects of MeHg exposure in birds have changed with time and researcher interest. Measures of oxidative stress were most consistently affected by MeHg exposure in birds. NMDA, acetylcholinesterase, and Purkinje cells also seem to be sensitive to MeHg exposure. Additional research is needed to validate the effects of MeHg on neurotransmitter systems in birds.
Article
Pharmacology & Pharmacy
B. Martins, J. P. Novo, E. Fonseca, R. Raposo, V. A. Sardao, F. Pereira, R. B. Oria, C. Fontes-Ribeiro, J. Malva
Summary: Methylmercury is a dangerous environmental contaminant that accumulates in the food chain and has neurotoxic properties. This study found that high concentrations of methylmercury can impair cell production, decrease the release of inflammatory mediators, and increase cell death.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aline H. Sousa, Joao P. G. Pereira, Allan C. Malaquias, Fernanda do E. S. Sagica, Edivaldo H. C. de Oliveira
Summary: Mercury is widely used in industrial processes and improper disposal of waste or products containing this metal can have significant negative impacts on ecosystems and living organisms, including humans. Methylmercury, a highly toxic organic compound, can cause neurological and developmental impairments. Recent research has shown that mercurial compounds can also cause genotoxic effects, such as disrupting mitotic spindle and causing chromosome loss, which are associated with the neurological effects of mercury. This study aimed to investigate the cytotoxic and genotoxic potential of methylmercury in neuron and glia cell lines. The findings showed that glial cells had a higher tolerance to methylmercury compared to neuronal cells, leading to higher intracellular accumulation of mercury and the occurrence of genotoxic effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rebecca von Hellfeld, Christoph Gade, Neil Vargesson, Astley Hastings
Summary: With the increasing annual chemical development and production, there is a growing demand for safety testing. QSAR modeling can predict the biological effect of a chemical structure, but there is insufficient toxicity data for different mercury species.
Review
Toxicology
Geir Bjorklund, Halyna Antonyak, Alexandr Polishchuk, Yuliya Semenova, Marta Lesiv, Roman Lysiuk, Massimiliano Peana
Summary: Methylmercury is a global environmental pollutant with neurotoxic effects, even at levels well tolerated by adults. This article reviews the mechanisms of methylmercury toxicity during nervous system development and discusses potential neuroprotective strategies.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Engineering, Environmental
Francisco Carlos da Silva Junior, Thais Agues-Barbosa, Ana Carolina Luchiari, Silvia Regina Batistuzzo de Medeiros
Summary: The study demonstrates the genotoxic and neurotoxic effects of Retene on zebrafish, indicating the potential to induce DNA micronuclei formation and behavioral changes. The results suggest that alterations in oxidative stress and mRNA expression of neurotransmitter systems may contribute to these effects.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Kathryn M. Pflug, Dong W. Lee, Kassandra McFadden, Linda Herrera, Raquel Sitcheran
Summary: The prognosis of high-grade gliomas, such as glioblastoma multiforme (GBM), is very poor due to their highly invasive nature. Previous studies have shown that TWEAK can promote the invasiveness of GBM cells through the noncanonical NF-.B pathway, with NIK being a key player. Our study reveals that NIK is upregulated at the transcriptional level in invading cells, and high expression of NIK facilitates collective invasion of GBM cells. Additionally, we demonstrate that E2F4 and E2F5 transcription factors are involved in the regulation of NIK transcription and the promotion of GBM cell invasion in response to TWEAK.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yue Wang, Lin Li, Xia Ning, Nan Sang, Guangke Li
Summary: Landfill leachate has become a public health concern due to its adverse effects. In this study, mung beans and zebrafish were used to investigate the toxicological effects of landfill leachate. The results showed that exposure to landfill leachate caused developmental toxicity and genotoxicity in plants and fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Biomaterials
Seyma Tasdemir, Zehra Gul Morcimen, Asli Aybike Dogan, Cansu Gorgun, Aylin Sendemir
Summary: Graphene and its derivatives are widely used for biomedical applications due to their unique physicochemical properties. This study examined the in vitro neurotoxicity of graphene with different surface areas on dopaminergic neuron model cells. The results showed that both sizes of graphene had increased cell viability in decreasing concentrations, but cell damage increased with higher surface area. The study also found that graphene had antioxidant effects on the neurons and did not show genotoxicity on either surface area.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Environmental Sciences
Vanessa Bezerra, Wagner Ezequiel Risso, Claudia Bueno dos Reis Martinez, Juliana Delatim Simonato
Summary: The aim of this study was to evaluate the effects of duckweed (Lemna minor) on Prochilodus lineatus exposed to cadmium and nickel. The results showed that duckweed partially attenuated some adverse effects of cadmium and nickel, such as reducing acetylcholinesterase activity, decreasing erythrocytic nuclear abnormality frequency, and alleviating hyperglycemia. However, duckweed did not mitigate changes in plasma ion concentrations, reduction in activity of ion transport enzymes, and histological damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Food Science & Technology
Linlin Ni, Yanfeng Wei, Jingjing Pan, Xiaoyang Li, Bin Xu, Yu Deng, Tianyao Yang, Wei Liu
Summary: The study found that MeHg dose-dependently induced pathological changes, increased levels of autophagy and apoptosis in the cerebral cortex. Rapamycin pretreatment antagonized MeHg-induced apoptosis, while 3-methyladenine further aggravated apoptosis. This suggests that mTOR and Vps34 may play important roles in mediating autophagy, which in turn regulates apoptosis through MAPKs or mitochondrial apoptosis pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Shubhankar Das, Ajanta Paul, Kamalesh D. Mumbrekar, Satish B. S. Rao
ENVIRONMENTAL TOXICOLOGY
(2017)
Article
Oncology
Kamalesh Dattaram Mumbrekar, Satish Rao Bola Sadashiva, Shama Prasada Kabekkodu, Donald Jerard Fernandes, Bejadi Manjunath Vadhiraja, Tomo Suga, Yoshimi Shoji, Fumiaki Nakayama, Takashi Imai, Kapaettu Satyamoorthy
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Biochemistry & Molecular Biology
Visesh Kumar Rathi, Shubhankar Das, Archana Parampalli Raghavendra, Bola Sadashiva Satish Rao
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2017)
Article
Engineering, Biomedical
Bharath Rathnakar, Bola Sadashiva Satish Rao, Vijendra Prabhu, Subhash Chandra, Krishna Kishore Mahato
LASERS IN MEDICAL SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Suma Prabhu, Jayant Sastri Goda, Srinivas Mutalik, Bhabani Shankar Mohanty, Pradip Chaudhari, Sharada Rai, Nayanabhirama Udupa, Bola Sadashiva Satish Rao
Article
Spectroscopy
Manjunath Siddaramaiah, Kapaettu Satyamoorthy, Bola Sadashiva Satish Rao, Suparna Roy, Subhash Chandra, Krishna Kishore Mahato
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2017)
Article
Dentistry, Oral Surgery & Medicine
N. V. Ballal, S. Das, B. S. S. Rao, M. Zehnder, D. Mohn
INTERNATIONAL ENDODONTIC JOURNAL
(2019)
Article
Environmental Sciences
Adwaid Manu Krishna Chandran, Hannah Christina, Shubhankar Das, Kamalesh D. Mumbrekar, B. S. Satish Rao
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shubhankar Das, Manjunath B. Joshi, Guruprasad K. Parashiva, Satish B. S. Rao
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Dentistry, Oral Surgery & Medicine
L. Giardino, A. Bidossi, M. Del Fabbro, P. Savadori, M. Maddalone, L. Ferrari, N. Ballal, S. Das, B. S. S. Rao
INTERNATIONAL ENDODONTIC JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Rashi Kanoi, Pooja Loachan, Shubhankar Das, Bola Sadashiva Satish Rao
Summary: Chronic oxidative stress has been linked to various human ailments, including aging. Studies have shown a causal relationship between oxidative stress, aging, and cellular senescence. The findings suggest that Mangiferin may have potential as a cytoprotective agent against premature cell senescence induced by chronic oxidative stress.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nidambur Vasudev Ballal, Rajkumar Narkedamalli, Poornika Gandhi, Maria Teresa Arias-Moliz, Pilar Baca, Shubhankar Das, Jothi Varghese, Santosh Laxman Gaonkar, Bola Sadashiva Satish Rao, Joshua Frazier, Brian E. Bergeron, Franklin R. Tay
Summary: This study evaluated the capacity of three 2-in-1 root canal irrigating solutions in removing canal wall smear layer, precipi-tation caused by irrigant interaction, antibacterial activity, and cytotoxicity. The results showed that QMix and SmearOFF were effective in removing smear layers and exhibited good antimicrobial activity. However, QMix and Irritrol showed cytotoxicity. The evaluation of smear layer removal capability, antibacterial activity, and cytotoxicity of 2-in-1 root canal irrigants is important for ensuring their safe use during root canal treatment.
JOURNAL OF DENTISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pooja R. Kamath, Dhanya Sunil, Shubhankar Das, Abdul Ajees Abdul Salam, B. S. Satish Rao
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)