Article
Chemistry, Medicinal
Noah R. Flynn, S. Joshua Swamidass
Summary: Cytochrome P450 enzymes play a crucial role in drug metabolism, but can also generate reactive metabolites that may cause adverse reactions. In this study, a new model was developed using XenoNet 1.0 as a tool to generate metabolic networks and predict the authenticity of inferred Phase I metabolite structures. The model outperformed previous work and baselines, achieving high accuracy in separating observed and unobserved metabolites. The approach also proved robust in varying network contexts and showed potential for identifying new metabolites for experimental study.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Noah R. Flynn, S. Joshua Swamidass
Summary: Cytochrome P450 enzymes can eliminate small molecule drugs, but may produce reactive metabolites that react adversely with protein and DNA, leading to drug attrition or withdrawal. Previous models have helped understand how these enzymes modify molecule structure, but an integrative approach is needed to understand the network-level behavior of progenitor molecules. We developed a tool called XenoNet 1.0 that generates metabolic networks and extended it with a bidirectional message passing neural network. Our model significantly outperformed prior work and baselines, accurately predicting metabolite structures and important metabolic subnetworks.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Rohit Pal, Karanvir Singh, Shah Alam Khan, Pooja Chawla, Bhupinder Kumar, Md Jawaid Akhtar
Summary: Antiepileptic drugs can form reactive metabolites that may lead to dangerous adverse reactions, making it imperative for pharmaceutical companies to minimize this bioactivation potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Xiaolan Hu, Jian-Lin Wu, Wen Miao, Fei Long, Hudan Pan, Tao Peng, Xiaojun Yao, Na Li
Summary: This research characterized the protein modification of bisphenol A (BPA) in rats using liquid chromatography-tandem mass spectrometry (LC-MS) approaches. The results showed that covalent protein modification played a critical role in BPA-induced hepatotoxicity, which can lead to oxidative damage by disrupting the enzymatic functions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mary Alexandra Schleiff, Sasin Payakachat, Benjamin Mark Schleiff, S. Joshua Swamidass, Gunnar Boysen, Grover Paul Miller
Summary: The study identified a family of seven clinically relevant diphenylamine NSAIDs, which can be categorized into acetic acid and propionic acid subgroups with varying hepatotoxicity risks and bioactivation propensities. Structural modifications to the diphenylamine scaffold were found to influence the preference and efficiency of bioactivation pathways, leading to differences in metabolic reactions among the drugs.
Review
Biochemistry & Molecular Biology
Alison Jee, Samantha Christine Sernoskie, Jack Uetrecht
Summary: IDILI remains a significant problem for patients and drug development due to its idiosyncratic nature. Most cases of IDILI are likely caused by reactive metabolites of drugs and mediated by the adaptive immune system, with some associations with specific human leukocyte antigen haplotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Dong Lu, Xin Yu, Hanfeng Lin, Ran Cheng, Erika Y. Monroy, Xiaoli Qi, Meng C. Wang, Jin Wang
Summary: Proteolysis-targeting chimeras (PROTACs) and targeted covalent inhibitors (TCIs) are two exciting strategies in the fields of chemical biology and drug discovery. The emergence of covalent PROTACs, which combine these two strategies, has gained increasing interest in recent years. This review highlights the mechanism and advantages of TCIs and PROTACs, and discusses the recent development of covalent PROTACs using irreversible and reversible covalent chemistry.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Chunjing Guan, Guode Zhao, Chen Sun, Mingyu Zhang, Siyu Liu, Ziying Jiang, Weiwei Li, Ying Peng, Jiang Zheng
Summary: This study aims to characterize the reactive metabolites of IPC in vitro and in vivo, identify the cytochrome P450 enzymes responsible for metabolic activation, and determine the correlation between metabolic activation and cytotoxicity of IPC. Results showed that GSH and NAC conjugates were detected after IPC exposure in GSH- or NAC-supplemented microsomal incubations. These conjugates were also found in mouse liver homogenates and urine after IPC administration. IPC was found to be metabolized to a quinone intermediate reactive to GSH, and it induced cytotoxicity in cultured mouse primary hepatocytes. The cytotoxicity was attenuated by the selective CYP3A4/5 enzyme inhibitor, ketoconazole.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Chunyong He, Yuchang Mao, Hong Wan
Summary: The formation of reactive metabolites is considered to be a cause of idiosyncratic adverse drug reactions, leading to drug attritions and recalls. Minimizing or eliminating the formation of reactive metabolites is an effective strategy to reduce the risk of adverse reactions and cytochrome P450 enzyme inhibition. This article highlights the role of reactive metabolites in idiosyncratic adverse drug reactions and cytochrome P450 enzyme inhibition, discusses the assessment of reactive metabolites in the discovery stage, and suggests strategies to minimize or eliminate their liability. Considerations for handling a reactive metabolite-positive drug candidate are also provided.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Ortuzar, Kersti Karu, Daniela Presa, Goreti R. Morais, Helen M. Sheldrake, Steve D. Shnyder, Francis M. Barnieh, Paul M. Loadman, Laurence H. Patterson, Klaus Pors, Mark Searcey
Summary: This study examines the potential cytochrome P450 (CYP)-mediated cancer cell killing ability of seco-OH-chloromethylindoline (CI) duocarmycin-based bioprecursors. Results demonstrate up to a 10-fold increase in bioactivation of de-OH CI-MI and a fluoro bioprecursor analogue in CYP1A1-transfected cells. Additionally, it is shown that CYP1A2, but not CYP1B1 or CYP3A4, has a propensity for potentiating these compounds, indicating a preference for CYP1A bioactivation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Lloyd Wei Tat Tang, Eric Chun Yong Chan
Summary: Metabolic activation of drugs by P450 enzymes can lead to liver injury, and these labile intermediates can cause irreversible inhibition. Efforts have been made to minimize metabolic activation and its negative effects. This review summarizes the fundamental aspects of P450 metabolic activation, discusses the metabolic activation pathways of a class of new drugs, and explores the limitations of existing methods and a promising new strategy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Robert J. Fontana, Einar S. Bjornsson, Rajender Reddy, Raul J. Andrade
Summary: Idiosyncratic drug-induced liver injury (DILI) is a rare but significant cause of liver disease. Newly identified causes of DILI include COVID vaccines, turmeric, green tea extract, and immune checkpoint inhibitors. DILI is diagnosed through exclusion, requiring evaluation for more common causes and a temporal association with the suspected drug. Advances in DILI causality assessment and drug-specific HLA associations have improved diagnosis and prognosis. LiverTox provides important information on the hepatotoxicity profile of medications and supplements.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Chemistry, Medicinal
Jack Uetrecht
Summary: The founding of Chemical Research in Toxicology has played an important role in the study of idiosyncratic drug reactions (IDRs). Reactive metabolites and immune mechanisms have been investigated in IDRs, but there are differences in the mechanisms and pharmacological effects caused by different drugs. Studying the innate immune response may provide a more accurate way to screen drugs for their potential to cause IDRs.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Toxicology
Ege Arzuk, Mehmet Tokdemir, Hilmi Orhan
Summary: Mitochondria are the major target of paracetamol-induced hepatotoxicity. This study found that mitochondrial CYPs can catalyze the formation of toxic metabolite NAPQI from paracetamol, leading to the transmission of death signals. However, in the kidneys, there is no correlation between the formation of NAPQI and kidney CYP2E1 activity, suggesting a different toxicity mechanism compared to the liver.
TOXICOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Ege Arzuk, Fuat Karakus, Hilmi Orhan
Summary: The study suggests that clozapine-induced cardiotoxicity may be caused by the activation of cardiac mitochondria. Mitochondria in cardiac tissue contain CYP enzymes that can catalyze the formation of reactive metabolites from clozapine. Clozapine significantly reduces mitochondrial oxygen consumption rate, providing an explanation for its adverse effects on the heart.
Article
Engineering, Electrical & Electronic
Neng-Wu Liu, Bing-Bing Huang, Lei Zhu, Guang Fu
Summary: A low-profile microstrip patch antenna with enhanced isolation bandwidth is proposed using characteristic mode analysis. The unused modes are suppressed through loaded pins. By combining the magnetic wall and electrical wall of two modes via pins, the nulls of the electric fields are shifted to the unexcited port, resulting in two minimum mutual coupling poles. The radiator length is then enlarged to improve isolation bandwidth and reshape the nonbroadside pattern.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Hui Deng, Lei Zhu
Summary: This study presents a novel hybrid coupling interface (HCI) technique that achieves self-decoupling between two dual-frequency patch antennas (DFPAs) for the first time, without the need for external structures. A decoupling condition based on network analysis indicates that the DFPA must have two independent coupling interfaces (CIs) to achieve self-decoupling at two operating frequencies simultaneously. An actual DFPA with HCI, composed of a rectangular patch and a short-circuited λ/4 microstrip resonator, is proposed and constructed in a two-element array, demonstrating that decoupling can be achieved by adjusting the radius of the shorting pin conveniently. Experimental results show that the in-band isolation between the two antennas can be enhanced beyond 15 dB across two operating frequency ranges.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Engineering, Civil
Haoxuan Du, Pubing Yu, Lei Zhu, Kai Fei, Liang Gao
Summary: Portraying wind fields is crucial for storm surge simulation, including storm track, wind speed, wind speed radius, and pressure drop. This study evaluates the performances of five parametric wind models in predicting storm surges in the Pearl River Estuary. The synthetic wind fields show that different models produce wind fields with diverse structures, each with its own focus and advantages. The selection of wind models significantly affects wind and surge estimates, with potential surge height errors greater than 1.45m. The study also highlights the uncertainties in storm track parameters and drag coefficient. The proposed model by Emanuel and Rotunno (2011) yields accurate estimates among the selected wind models, while small track changes and drag coefficient variations contribute to significant uncertainty.
JOURNAL OF WIND ENGINEERING AND INDUSTRIAL AERODYNAMICS
(2023)
Article
Archaeology
Zhu Lei, Yi Weitong, Lan Desheng, Zhou Ping, Jiang Yonghui, Xia Yin, Hu Yungang, Li Xiaoxi, Hou Miaole, Chen Xi, Fu Qianli
Summary: This paper presents the structural mechanical analysis of the Terracotta Warriors using 3D laser scanning technology and finite element methodology. The workflow includes steps such as point cloud capture, reverse modeling, mesh generation, and analysis, utilizing different software. By analyzing sculpture cases at different angles, it is found that apart from the ankle, the thigh and hip joints are also affected adversely under gravity. Rotating the sculpture at an appropriate angle can help reduce the stress on the structure.
STUDIES IN CONSERVATION
(2023)
Article
Engineering, Chemical
Lei Zhu, Chengyong Liu, Wenzhe Gu, Chaofeng Yuan, Yuyi Wu, Zhicheng Liu, Tianqi Song, Fengtian Sheng
Summary: This study investigates the influencing factors of floor deformation and floor heave mechanisms in deep mining roadways using a combination of theoretical analyses, numerical simulations, and field observations. It is found that factors such as large buried depth, long duration of dynamic pressure, unique characteristics of surrounding rock, and insufficient support strength contribute to floor heave. A mechanics model of the roadway floor beam is established, determining the correlations between floor displacement and elastic modulus, floor thickness, buried depth of roadway, roadway width, and fracture zone width. Numerical simulations confirm the control effect of increasing floor rock thickness, strengthening floor rock elastic modulus, and enhancing side wall strength on floor displacement. On-site application of bottom lifting + bottom angle bolt + floor bolt control method effectively reduces floor heave volume, meeting the requirements of the roadway and validating the theoretical and numerical simulation results indirectly.
Article
Nuclear Science & Technology
Xiaoyan Tian, Sen Chen, Lixin Chen, Huaqi Li, Leitai Shi, Da Li, Xiaofei Luo, Lei Zhu, Weitong Li, Xiaoya Kang
Summary: In this study, a visualized experimental analysis on flow instability phenomenon in a natural circulation system was conducted using deionized water. Different types of flow instability under different heating powers were identified and studied, and the influence of heating power, inlet pressure, and temperature on pressure drop oscillations (PDO) was investigated. The experimental results showed the flow experienced three stages: single-phase, sub-cooled boiling two-phase, and unstable saturated boiling two-phase, with increasing heating power. The analysis demonstrated that the critical heating power of PDO increased with system pressure and decreased with the inlet temperature of the test section. The findings provide insight into flow instability characteristics and facilitate the improvement of flow stability in natural circulation loops under low-pressure conditions.
PROGRESS IN NUCLEAR ENERGY
(2023)
Article
Chemistry, Physical
Brandon D. D. Nusser, Joseph V. V. Accardo, Lei Zhu
Summary: This work reports the fluorescence, phosphorescence, and photochemical properties of di- and triaryl-substituted-1,2,3-triazoles. The synthesis of regioisomers of substituted triazoles enables a systematic study on the correlation between regiochemistry and excited state properties. The position of the substituent has a significant impact on the fluorescence emission energy, singlet-triplet energy gap, and photochemical reactivity and stability.
Article
Engineering, Electrical & Electronic
Mei Li, Zhi Yang, Zhehao Zhang, Ming-Chun Tang, Lei Zhu
Summary: A miniaturized, high-gain, circular polarization (CP) -reconfigurable antenna using a slow-wave transmission line (SW-TL)-based annular ring is developed. The detailed configuration and working mechanism of the CP-reconfigurable antenna are presented. The antenna exhibits a high gain of 7.83 dBic under a miniaturized annular ring radiator with radius of 0.136?(0), as verified by measured and simulated results.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Shi-Tong Wang, Lei Zhu
Summary: This article presents a novel multimode method for proposing and designing a null reconfigurable patch antenna. The characteristics of a multimode antenna are theoretically investigated, and the conditions for null formation are established based on a unified equivalent circuit model. Two prototypes, a single-plane null reconfigurable antenna (NRA) on a rectangular patch and a hemispherical NRA on a circular patch, are fabricated and measured to demonstrate the effectiveness and applicability of the proposed method.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Zhe-Jia He, Lianwen Deng, Pin Zhang, Yawen Liu, Tianyi Yan, Congwei Liao, Shengxiang Huang, Lei-Lei Qiu, Lei Zhu
Summary: In this paper, a wideband rectifying metasurface (RMS) for RF energy harvesting (EH) is proposed. The RMS utilizes the resonant modes of the paralleling metasurface (MS) resonator to achieve wideband feature and direct impedance matching, eliminating the need for impedance matching. A dc feed structure is also introduced to combine and export dc energy directly, eliminating power combining networks. Experimental results show that the proposed RMS system operates at a frequency range of 5.32-6.66 GHz with a fractional bandwidth of 22.4% and a peak efficiency of 74.5%. This work contributes to capturing RF energy on a broader frequency range with higher system efficiency and a simple structure, showing great potential in wireless power transfer and indoor RF EH.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Computer Science, Artificial Intelligence
Lei Yang, Xinyu Zhang, Jun Li, Li Wang, Minghan Zhu, Lei Zhu
Summary: This paper proposes a lightweight feature pyramid network (Lite-FPN) and an effective regression loss (attention loss) for keypoint-based monocular 3D object detectors in autonomous driving. Experimental results demonstrate significant accuracy improvements by performing multi-scale feature fusion only at sparsely distributed keypoint locations and addressing the misalignment between classification score and localization precision using attention loss. Furthermore, the enhanced performance of SMOKE with our Lite-FPN module surpasses the baseline enhanced by the classic FPN.
KNOWLEDGE-BASED SYSTEMS
(2023)
Article
Engineering, Manufacturing
Xuzhou Yu, Sai-Wai Wong, Jing-Yu Lin, Yejun He, Wenting Li, Long Zhang, Lei Zhu, Li Yu
Summary: This article proposes a design of a bandpass filter (BPF) based on stepped window resonators (SWRs) that allows inline resonators to generate transmission zeros (TZs). The proposed SWR consists of two metal cavities without any coupling iris, with the larger cavity acting as a bandstop resonator to provide TZs near the passband. The design methodology is validated through the fabrication and measurement of a fourth-order inline BPF with a fractional bandwidth of 1% at 10 GHz.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Chaoqun Zheng, Fengling Li, Lei Zhu, Zheng Zhang, Wenpeng Lu
Summary: This paper proposes a Structured Multi-Modal Hashing (SMMH) method, which can learn only a hash model for multiple multimedia retrieval tasks.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Computer Science, Information Systems
Chenghan Li, Yipu Liao, Rongjia Sun, Ruisheng Diao, Ke Sun, Jian Liu, Lei Zhu, Yunpeng Jiang
Summary: The fast adoption of electric vehicles has raised concerns about the planning and operation of the distribution power system. To accurately predict EV charging load series, a two-stage time series decomposition and BiLSTM deep learning architecture is proposed. The performance of the proposed architecture outperforms traditional algorithms in terms of MAPE and RMSE metrics for EV load prediction.
Proceedings Paper
Engineering, Electrical & Electronic
Li Yong, Zhu Lei, Xu Ziqiang, Xiao Yusong, Ji Xuebiao
Summary: Oil-immersed transformer is crucial for the power grid, and ensuring its safe operation is essential for power system reliability. Dissolved gas analysis can detect defects and potential faults, but the non-stationary and nonlinear variation of dissolved gas concentration limits accuracy. To improve prediction accuracy, this paper proposes a model combining EMD and BiGRU. EMD stabilizes the gas concentration series, while BiGRU predicts sub-sequence components. The method reduces data nonstationarity and significantly improves prediction accuracy, enhancing equipment lifespan and power grid reliability.
2023 5TH ASIA ENERGY AND ELECTRICAL ENGINEERING SYMPOSIUM, AEEES
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
