Article
Biochemistry & Molecular Biology
Malgorzata Zaklos-Szyda, Nina Pietrzyk, Agnieszka Kowalska-Baron, Adriana Nowak, Katarzyna Chalaskiewicz, Marcin Ratajewski, Grazyna Budryn, Maria Koziolkiewicz
Summary: The chronic consumption of large amounts of fructose in food has been linked to hypertension and disturbances in carbohydrate and lipid metabolism, leading to obesity, non-alcoholic fatty liver disease, insulin resistance, and type 2 diabetes. The absorption of fructose by small intestine cells and hepatocytes is mediated by proteins such as GLUT5. Extracts from plants like B. juncea and M. chamomilla have been shown to reduce fructose uptake and downregulate GLUT5 expression, potentially through the inhibition of transcription factors TXNIP and ChREBP.
Article
Chemistry, Applied
Carlos M. Donado-Pestana, Erika V. M. Pessoa, Larissa Rodrigues, Rafaela Rossi, Marcio H. C. Moura, Priscila R. dos Santos-Donado, Erique Castro, William T. Festuccia, Maria Ines Genovese
Summary: Polyphenols from Cambuci have therapeutic actions in alleviating insulin resistance and hepatic steatosis in obese mice fed with a high-fat-sucrose diet. The effects include reductions in body weight gain, inflammation, hyperglycemia, and improvement in glucose intolerance and insulin resistance through the activation of Akt and AMPK.
Review
Nutrition & Dietetics
Berner Andree Sandoval-Ramirez, Ursula Catalan, Anna Pedret, Rosa M. Valls, Jose Ma Motilva, Laura Rubio, Rosa Sola
Summary: Oral administration of phenolic compounds improves intestinal barrier integrity in animals by reducing inflammatory molecules, enhancing tight-junction protein expression, and boosting antioxidant activity.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Huimin Jin, Siyan Che, Kunfu Wu, Miaomiao Wu
Summary: This study found that ellagic acid (EA) has the potential to replace antibiotics to prevent microbial-mediated immune responses and alleviate inflammation caused by intestinal stress. EA preprocessing reduced the abundance of Streptococcus in the gut, modulated the distribution of intestinal lymphocytes, reduced the frequency of specific cells, and alleviated the upward migration of cells to the apex of the intestinal villi.
Article
Biochemistry & Molecular Biology
Yunqing Wang, Ganwarige Sumali N. Fernando, Natalia N. Sergeeva, Nikolaos Vagkidis, Victor Chechik, Thuy Do, Lisa J. Marshall, Christine Boesch
Summary: The present study compared the absorption and transport patterns of three main betalains, betanin, vulgaxanthin I, and indicaxanthin, in intestinal epithelial cells. The results showed that these compounds have different molecular effects on inflammatory and redox-related cell signaling. Betanin demonstrated a potent dose-dependent radical scavenging activity.
Review
Food Science & Technology
Ana Paula da Fonseca Machado, Roberto de Paula do Nascimento, Mariana da Rocha Alves, Livia Mateus Reguengo, Mario Roberto Marostica Junior
Summary: Latin America boasts a variety of native plants, including the Astrocaryum genus, which have potential medicinal and technological uses. Two native Brazilian fruits, tucuma-do-Amazonas and tucuma-do-Para, are rich in antioxidants and bioactive compounds, showing promise in preventing and treating diseases. Additionally, tucuma plants have potential industrial applications such as biofuel production and alternative packaging materials.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Jaroslaw Czubinski
Summary: The study reveals that gamma-conglutin is the main protein fraction released from lupin seeds during high-temperature incubation. The monomeric form of gamma-conglutin shows increased interaction strength with flavonoids and enhanced inhibitory activity against glycoside hydrolases at specific temperatures.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Applied
Carolina Otero, Sebastian Miranda-Rojas, Felipe M. Llancalahuen, Juan A. Fuentes, Cristian Atala, Gloria Gonzalez-Silva, Diego Verdugo, Paulina Sierra-Rosales, Adrian Moreno, Felipe Gordillo-Fuenzalida
Summary: Peumus boldus is an endemic tree species from Chile, with its leaves and bark being the focus of study for decades. Research has found that extracts contain alkaloids and flavonoids, showing antioxidant and anti-inflammatory activities. In vitro testing of fruit extract demonstrated anti-inflammatory activity, suggesting potential health benefits for the Chilean population.
Article
Food Science & Technology
Andressa S. Fernandes, Tatiele C. Nascimento, Pricila N. Pinheiro, Veridiana V. de Rosso, Cristiano R. de Menezes, Eduardo Jacob-Lopes, Leila Q. Zepka
Summary: The study investigated the bioaccessibility and uptake of chlorophyll pigments from Scenedesmus obliquus in human intestinal cells for the first time. Different products were evaluated, with isolated chlorophyll extract showing the highest bioaccessibility for intestinal uptake.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Thaise Boeing, Silvia Speca, Priscila de Souza, Anthony Martin Mena, Benjamin Bertin, Pierre Desreumax, Luisa Mota da Silva, Sergio Faloni de Andrade, Laurent Dubuqoy
Summary: Luteolin can reduce inflammation and oxidative stress induced by irinotecan in Caco-2 cells by upregulating the expression of PPAR gamma, HO-1, and SOD genes, and decreasing the expression of IL-1 beta and iNOS. However, when PPAR gamma expression is downregulated, luteolin loses this effect.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Sonia Saib, Sophie Hodin, Clement Mercier, Mireille Paul, Valerie Bin, Edouard Oilier, Xavier Delavenne
Summary: This study investigated the impact of pro-inflammatory cytokines on the expression and activity of P-gp in intestinal and renal cells. The results showed that cytokines can alter the gene expression and functionality of P-gp, potentially leading to altered exposure to drug substrates.
MOLECULAR PHARMACEUTICS
(2022)
Article
Immunology
Rowayna Shouib, Gary Eitzen
Summary: Airway epithelial cells can respond to pathogens and stimulants through cytokine and chemokine secretion, but excessive secretion can cause chronic inflammation and pulmonary disorders. We identified Cdc42 as an important signaling molecule that regulates cytokine production and release. Inhibiting or silencing Cdc42 affected the gene expression and secretion of specific cytokines, particularly IL-8 trafficking and secretion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Andrea Toschi, Andrea Piva, Ester Grilli
Summary: The study aimed to evaluate the effects of phenolic compounds on intestinal oxidation and barrier integrity. The results showed that phenol-rich botanicals had a positive effect on intestinal cells and could potentially improve intestinal barrier function. This is important for controlling gut barrier function and reducing the negative effects of oxidative stress.
Article
Biochemistry & Molecular Biology
Francesca Truzzi, Anne Whittaker, Eros D'Amen, Maria Chiara Valerii, Veronika Abduazizova, Enzo Spisni, Giovanni Dinelli
Summary: Increases in non-communicable and auto-immune diseases have led to research on natural products and the interrelationship between autophagy and inflammation. The study investigates the effects of wheat-germ spermidine and clove eugenol combination supplement on inflammation and autophagy. Results show that the supplement reduces ROS levels and midkine expression, stimulates autophagy, and improves intestinal health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cristina P. B. Melo, Priscila Saito, David L. Vale, Camilla C. A. Rodrigues, Ingrid C. Pinto, Renata M. Martinez, Julia Rojo Bezerra, Marcela M. Baracat, Waldiceu A. Verri Jr, Yris Maria Fonseca-Bazzo, Sandra R. Georgetti, Rubia Casagrande
Summary: Cordia verbenacea extract demonstrates strong antioxidant properties, effectively inhibiting inflammation and oxidative stress in the skin caused by UVB exposure. This medicinal plant extract shows potential as a therapeutic approach for protecting the skin from damage.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)