Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats

The effect of 2,2-dichlorovinyl dimethyl phosphate on redox homeostasis in male rats was investigated. Rats were grouped into four: A, B, C and D where A (the control) received orally 1 ml of distilled water; B, C and D (test groups) received orally 2.5, 5 and 10 mg/kg body weight of DDVP respectively for 28 days. DDVP administration significantly reduced (P<0.05) the alkaline phosphatase activity in the liver and kidney with corresponding increases in the serum. Acid phosphatase activity increased significantly (P<0.05) in liver and kidney, while there was no significant change (P>0.05) in the serum acid phosphatase activity. There was also a significant decrease (P<0.05) in the activities of superoxide dismutase. catalase, glutathione peroxidase and glutathione reductase in the liver and kidney. Liver and kidney levels of GSH, vitamins C and E were also significantly reduced (P<0.05). Serum malonidialdehyde and lipid hydroperoxide also increased significantly (P<0.05) in all DDVP treated groups. The available data from this study revealed that DDVP brings about its toxicity through depletion of the antioxidant systems and thus exposing the cells and cellular macromolecules to oxidative attacks by reactive oxygen species generated either from its metabolites or other in vivo means. (C) 2010 Elsevier Ireland Ltd. All rights reserved.