期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 171, 期 1, 页码 45-56出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2007.08.010
关键词
Polyalthia longifolia; cytotoxicity; apoptosis; HL-60 cells
Polyalthia longifolia is a lofty evergreen tree found in India and Sri Lanka. We are reporting first time the anticancer potential of P longifolia leaves extract (A001) and its chloroform fraction (17002). Both inhibited cell proliferation of various human cancer cell lines in which colon cancer cells SW-620 showed maximum inhibition with IC50 value 6.1 mu g/ml. Furthermore, F002 induce apoptosis in human leukemia HL-60 cells as measured by several biological end points. F002 induce apoptotic bodies formation, DNA ladder, enhanced annexin-V-FITC binding of the cells, increased sub-Go DNA fraction, loss of mitochondrial membrane potential (A release of cytochrome c, activation of caspase-9, caspase-3, and cleavage of poly ADP ribose polymerase (PARP) in HL-60 cells. All the above parameters revealed that F002-induced apoptosis through the mitochondrial-dependent pathway in HL-60 cells. (c) 2007 Elsevier Ireland Ltd. All lights reserved.
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