Review
Chemistry, Organic
Diana Gimenez, Aoife Phelan, Cormac D. Murphy, Steven L. Cobb
Summary: F-19 NMR is widely used in the field of chemical biology for synthesizing new fluorinated probes, monitoring protein interactions, structural analysis, etc. It remains relevant for investigating the biosynthesis and biodegradation of fluorinated organic compounds.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Qing Miao, Christoph Nitsche, Henry Orton, Mark Overhand, Gottfried Otting, Marcellus Ubbink
Summary: Paramagnetic chemical probes have been widely used in EPR and NMR spectroscopy, especially in the study of biological macromolecules. Recent developments include an increase in the variety of paramagnetic probes, the development of lanthanoid probes for protein studies, and the development of isotropic paramagnetic probes for NMR and EPR measurements.
Review
Chemistry, Multidisciplinary
Qing Miao, Christoph Nitsche, Henry Orton, Mark Overhand, Gottfried Otting, Marcellus Ubbink
Summary: This review provides a comprehensive overview of the existing paramagnetic chemical probes, including chemical synthetic approaches, functional properties, and selected applications in the study of biological macromolecules. Recent developments have seen a rapid expansion of lanthanoid probes with anisotropic magnetic susceptibilities and isotropic paramagnetic probes for protein studies and investigations of biological macromolecules.
Article
Chemistry, Multidisciplinary
Zhenchuang Xu, Yanchuan Zhao
Summary: NMR technique is powerful but hindered by crowded spectra when analyzing complex real-world samples. This account summarizes the development of novel F-19-labeled probes for separation-free multicomponent analysis. Strategies for chiral discrimination, sensitivity enhancement, and automated analyte identification are discussed.
Article
Biology
Madalena Cipriano, Katharina Schluender, Christopher Probst, Kirstin Linke, Martin Weiss, Mona Julia Fischer, Lena Mesch, Kevin Achberger, Stefan Liebau, Marina Mesquida, Valeria Nicolini, Anneliese Schneider, Anna Maria Giusti, Stefan Kustermann, Peter Loskill
Summary: Researchers have developed a human immunocompetent Choroid-on-Chip model that mimics immune responses in the presence of immune cells, offering a potential tool for studying the interplay between the immune system and oncology. This model may provide insights into eye disorders causing visual impairment and serve as a platform for evaluating drug efficacy and toxicity mechanisms.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dmitry P. Krut'ko, Alexey V. Medved'ko, Konstantin A. Lyssenko, Andrei V. Churakov, Alexander I. Dalinger, Mikhail A. Kalinin, Alexey O. Gudovannyy, Konstantin Y. Ponomarev, Eugeny V. Suslov, Sergey Z. Vatsadze
Summary: In this study, the solution conformations of seventeen 3,7-diacyl bispidines were investigated using NMR spectroscopy, revealing the presence of syn/anti-isomers and their ratios in different environments. A new dynamic process and energy estimation for amide bond inversion were discovered, as well as unexpected mechanisms for the process.
Article
Business
Stephen L. France, Yuying Shi, Brett Kazandjian
Summary: This study discusses the use of Google Trends web search data for economic forecasting, with a focus on creating consistent and aggregated data. It also explores how Google Trends data can be utilized to create brand equity series and improve predictions of movie revenue.
JOURNAL OF BUSINESS RESEARCH
(2021)
Article
Chemistry, Physical
Ivan Hung, Zhehong Gan, Gang Wu
Summary: This study presents two- and three-dimensional C-13-O-17 heteronuclear correlation solid-state NMR experiments under magic-angle spinning (MAS) conditions. The experiments were performed on different samples using various schemes to achieve coherence transfer between C-13 and O-17 nuclei. This new 3D O-17 NMR experiment aims for site-resolved solid-state O-17 NMR studies, demonstrating successful correlations between O-17, C-13, and C-13 nuclei.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Lucrezia Cosottini, Stefano Zineddu, Lara Massai, Veronica Ghini, Paola Turano
Summary: In this study, we present a method to efficiently produce 5-F-Trp human H ferritin by selectively incorporating 19F into the side chain of W93 using 5-fluoroindole as the fluorinated precursor. Human H ferritin is a nanocage composed of 24 identical subunits, each containing a single Trp exposed on the external surface. The incorporation of 5-F-Trp allows for the study of intermolecular interactions and monitoring of ferritin uptake by cells, which has important applications in drug delivery.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Ana Bastos, Sebastian Sippel, Dorothea Frank, Miguel D. Mahecha, Soenke Zaehle, Jakob Zscheischler, Markus Reichstein
Summary: Extreme weather and climate events have significant impacts on ecosystems, and their frequency or intensity is projected to increase, which could amplify ecological impacts and reduce CO2 mitigation potential. However, current risk assessments often overlook the multiple feedbacks between ecosystems and climate extremes. To address this, the authors propose a systemic framework that combines climate risk assessment and disturbance ecology to analyze the causal relationships between climate extremes, disturbance regimes, and ecosystems. This framework can help understand the role of different factors in high-impact events, incorporate uncertainties, and quantify the human influence on such events.
NATURE REVIEWS EARTH & ENVIRONMENT
(2023)
Review
Agriculture, Multidisciplinary
Rafael Chelala Moreira, Rayanne Priscilla Franca de Melo, Julian Martinez, Mario Roberto Marostica Junior, Glaucia Maria Pastore, Holger Zorn, Juliano Lemos Bicas
Summary: This review explores the potential of using supercritical carbon dioxide (SC-CO2) in the flavor industry for extraction, fractionation, and synthesis of aroma esters. The advantages of SC-CO2, such as mild reaction conditions, time savings, reduced toxicity concerns, higher sustainability, and adjustable solvent selectivity, are compared to traditional methods. The findings suggest that SC-CO2 has the potential to selectively obtain compounds applicable in aroma technology and related fields.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
J. Peris-Vicente, Ester Peris-Garcia, Jaume Albiol-Chiva, Abhilasha Durgbanshi, Enrique Ochoa-Aranda, Samuel Carda-Broch, Devasish Bose, Josep Esteve-Romero
Summary: This review discusses the determination of antibiotics in biological, food and environmental samples using liquid chromatography. It emphasizes the pharmacological activity and sources of exposure to antimicrobial agents, and suggests the development of automated online detection protocols.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Fenfen Zhang, Wenbin Shen, Ming Yang
Summary: An accurate, simple and reproducible FNMR-F-19 method was developed and successfully applied to the determination of ticagrelor, showing no significant difference compared to the H-1 NMR method.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Henry W. Orton, Haocheng Qianzhu, Elwy H. Abdelkader, Edan I. Habel, Yi Jiun Tan, Rebecca L. Frkic, Colin J. Jackson, Thomas Huber, Gottfried Otting
Summary: In this study, it was demonstrated that fluorine atoms in noncanonical amino acids positioned in the hydrophobic core or on the surface of a protein can be linked by scalar through-space F-19-F-19 couplings, even if the F-19 spins are separated by more than the van der Waals distance. The use of fluorinated amino acids and F-19-F-19 interactions offer a straightforward way to probe the spatial proximity of selected sites in proteins, without requiring H-1 NMR resonance assignments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Polymer Science
Fabian Hoffmann, Karel Kouril, Stefan T. Berger, Benno Meier, Burkhard Luy
Summary: In this study, the formation of liquid crystalline phases of PBLG in CDCl3 is investigated using a home-built rheo-NMR apparatus. The effects of spinning speeds and shear forces on the alignment of the liquid crystalline phases are explored, and the influence of temperature, concentration, and shear rate on the alignment properties is characterized.
Article
Chemistry, Multidisciplinary
Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu
Summary: This study reports a biodegradable poly(aminoester) dendrimer for effective siRNA delivery, which features a lipid/dendrimer hybrid structure. It is of great significance for developing biodegradable and biocompatible vectors for siRNA therapeutics.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Thi Khanh Ly Nguyen, Trang N. T. Phan, Fabrice Cousin, Didier Devaux, Sumit Mehan, Fabio Ziarelli, Stephane Viel, Didier Gigmes, Priscillia Soudant, Renaud Bouchet
Summary: This paper focuses on increasing the lithium transport number by synthesizing POSS-based macroanions and studying their properties in electrolytes. It is found that the size of macroanions has a significant impact on transport number, electrolyte viscosity, and tortuosity. The chemical affinity between the organic POSS shell and the solvent also affects the dissociation rate of Li+ ions.
CHEMISTRY OF MATERIALS
(2022)
Article
Biology
Patricia Santofimia-Castano, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Summary: Mutations or treatment with the NUPR1 inhibitor ZZW-115 can inhibit the activity of PARP1 and induce cell death. Treatment with ZZW-115 or genetic inactivation of NUPR1 leads to mitochondrial catastrophe, which can be partially rescued by olaparib and NAD(+) precursor nicotinamide mononucleotide.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dao Le, Amelie Frison, Yasmine Masmoudi, Abir Bouledjouidja, Pierre Thureau, Giulia Mollica, Elisabeth Badens, Fabio Ziarelli, Stephane Viel
Summary: In this study, supercritical CO2 was used to impregnate polymers with paramagnetic polarizing agents for dynamic nuclear polarization solid-state NMR experiments. The results showed that scCO2 impregnation could significantly enhance the DNP signal, reaching a maximum value of 8. This method has the potential to be an efficient and versatile approach for preparing polymer samples for DNP ssNMR investigations.
MAGNETIC RESONANCE IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
A. Ya-Ting Huang, C. -L. Kao, A. Selvaraj, L. Peng
Summary: Dendrimers have a unique dendritic structure and multivalent cooperativity, making them promising for various applications. However, dendrimer synthesis faces challenges with structural defects and purification. Solid-phase synthesis can overcome these problems by enabling complete reactions and facilitating purification. This review discusses the challenges and current research in solid-phase dendrimer synthesis, as well as efforts to develop more effective methods.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Physical
D. Marin, G. Gerbaud, O. Margeat, F. Ziarelli, F. Ferrer, O. Ouari, A. Campos, S. Bertaina, A. Savoyant
Summary: The combination of nuclear and electron magnetic resonance techniques was used to study the light-induced magnetic state at the surface of chemically prepared zinc oxide nanoparticles. It was found that the observed four-line structure arises from surface-located methyl radicals and is replaced by trideuteromethyl with functionalization. Advanced pulse-EPR techniques reveal the modulation and correlations between different EPR transitions of the radicals.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Peng Zhang, Zhi Li, Weiling Cao, Jingjie Tang, Yi Xia, Ling Peng, Jing Ma
Summary: The study presents an effective strategy for treating metastatic breast cancer by using a self-assembling dendrimer nanosystem to deliver siRNA inhibiting PDK1 and modulating cancer metabolism, while promoting PD-1/PD-L1 pathway-based immunotherapy. This nanosystem, named PPD, effectively inhibits tumor growth and metastasis without notable toxicity in tumor-bearing mouse models. The results highlight the potential use of PPD as an effective and safe tumor-targeting therapy for breast cancer.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Florian Ferrer, Marie Juramy, Ribal Jabbour, Samuel Cousin, Fabio Ziarelli, Giulia Mollica, Pierre Thureau, Stephane Viel
Summary: Dynamic nuclear polarization can significantly improve the sensitivity of magic-angle spinning solid-state NMR experiments. The use of a glycerol-based DNP solution is common to prevent phase separation of the paramagnetic polarizing agents. However, this study demonstrates that high H-1 DNP enhancements can also be achieved in water without glycerol by adding high concentrations of electrolytes, which disrupt ice crystallization and restore DNP efficiency.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Biomedical
Marco Viola, Claudia Migliorini, Fabio Ziarelli, Stephane Viel, Claudia Cencetti, Daniel Di Risola, Luciana Mosca, Laura Masuelli, Pietro Matricardi, Chiara Di Meo
Summary: The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, has been extensively characterized and investigated, showing promising potential as an innovative excipient. It can enhance drug solubility, viscosity, and emulsifying properties, and forms stable hydrogel complexes with chitosan.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Samuel F. Cousin, Colan E. Hughes, Fabio Ziarelli, Stephane Viel, Giulia Mollica, Kenneth D. M. Harris, Arthur C. Pinon, Pierre Thureau
Summary: Solid-state DNP NMR can improve the detection of minor solid phases in heterogeneous materials. We demonstrated the use of NMR contrast based on DNP-enhanced polarization transport for the early detection of a small amount of a minor polymorphic phase within a major polymorph. We also showed that this approach allows for quantitative information on the spatial distribution of the two polymorphs.
Review
Materials Science, Biomaterials
Christina Galanakou, Dinesh Dhumal, Ling Peng
Summary: With the increasing concern for antimicrobial resistance, there is a need for novel antimicrobial agents that can effectively combat bacterial resistance without inducing further resistance development. Amphiphilic dendrimers are emerging as a promising solution, as they mimic antimicrobial peptides and possess stable dendritic structures that resist enzymatic degradation. These dendrimers can be precisely designed to optimize their hydrophobic-hydrophilic balance, resulting in potent antibacterial activity and minimal adverse effects. This review explores the challenges, mechanisms, and future prospects of using amphiphilic dendrimers as antibiotic substitutes to combat antimicrobial resistance.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Physical
Eric Besson, Aurelien Vebr, Fabio Ziarelli, Emily Bloch, Guillaume Gerbaud, Severine Queyroy, Pierre Thureau, Stephane Viel, Stephane Gastaldi
Summary: Dynamic nuclear polarisation (DNP) is a technique that enhances the sensitivity of solid-state nuclear magnetic resonance (SSNMR) experiments by transferring the electron spin polarisation of paramagnetic species to nuclei. This study focuses on porous materials with wall-embedded radicals and explores the relationship between the molecular structure and the theoretical distance between the embedded radicals. The results suggest that the silica materials with the shortest oxygen-oxygen distance between the embedded radicals exhibit the highest DNP efficiency.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng
Summary: Dendrimers, a special family of polymers, have promising applications in biomedical fields due to their dendritic structure and multivalency. This Account presents the use of amphiphilic dendrimers for delivering nucleic acids, specifically siRNA and mRNA. While lipid and polymer vectors are advanced nonviral delivery systems, only lipid vectors have been used clinically for delivering RNA. To address the need for innovative materials, lipid/dendrimer conjugates, called amphiphilic dendrimers, have been developed to combine the advantages of lipid and polymer vectors. These vectors mimic lipid vectors' membrane-fusion delivery mechanism and polymer vectors' endocytosis-based delivery, while also offering precise control and stability in a nanosized structure. The hydrophilic/hydrophobic balance of amphiphilic dendrimers plays a crucial role in successful RNA delivery. This Account provides an overview of the design and breakthroughs in amphiphilic dendrimers for siRNA and mRNA delivery, highlighting their historical development and promising features. The future of amphiphilic dendrimer vectors for nucleic acid delivery is also discussed.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Yikuan Liu, Xiaona Liu, An Su, Chengtao Gong, Shenwei Chen, Liwei Xia, Chengwei Zhang, Xiaohuan Tao, Yue Li, Yonghe Li, Tulai Sun, Mengru Bu, Wei Shao, Jia Zhao, Xiaonian Li, Yongwu Peng, Peng Guo, Yu Han, Yihan Zhu
Summary: Covalent organic frameworks are crystalline porous materials with designable structures and functions, which can acquire multifunctionalities and have versatile applications in gas separation/storage, catalysis, and optoelectronic devices.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut
Summary: Gene therapy has the potential to revolutionize the treatment of inherited and acquired diseases, but its success rate is currently limited. This review focuses on the obstacles faced by gene therapies in the human body, such as nucleic acid degradation by abundant nucleases, and discusses strategies to reduce degradation and methods to assess nucleic acid integrity.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Chenxi Duan, Chunming Cui
Summary: Low valent group 14 compounds with diazaborolyl substituents exhibit unique structures and reactivity due to the combination of sigma-electron donation and steric hindrance. The modulation of the HOMO-LUMO gap by the diazaborolyl substituents results in novel reaction patterns in the activation of small molecules and inert chemical bonds.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
David E. Salazar Marcano, Nada D. Savic, Kilian Declerck, Shorok A. M. Abdelhameed, Tatjana N. Parac-Vogt
Summary: Metal-oxo clusters have great potential in various fields and can react with biomolecules, making them promising for applications in disease treatment and energy development. They can also be used in the development of inorganic drugs and bioanalytical tools.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Lana K. Moree, Logan A. V. Faulkner, James D. Crowley
Summary: In this tutorial review, the general methods for synthesizing heterometallic metallosupramolecular architectures (MSAs), specifically heterometallic cages, are examined. The intrinsic properties and potential applications of these cages as host-guest systems and reaction catalysts are discussed.
CHEMICAL SOCIETY REVIEWS
(2024)
