Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol

Recent Developments in Asymmetric Organocatalytic Domino Reactions

(2012) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Organocatalytic Three-Component Petasis Reaction among Salicylaldehydes, Amines, and Organoboronic Acids

(2012) Wen-Yong Han et al.   ORGANIC LETTERS

One-Pot Asymmetric Synthesis of γ-Nitroaldehydes from Aldehydes and Nitroalkanes through a Catalytic Tandem Reaction Using an Amino Acid Lithium Salt

(2011) Masanori Yoshida et al.   JOURNAL OF ORGANIC CHEMISTRY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Organocatalytic Michael−Wittig−Michael−Michael Reaction: Dichotomous Construction of Pentasubstituted Cyclopentanecarbaldehydes and Pentasubstituted Cyclohexanecarbaldehydes

(2011) Bor-Cherng Hong et al.   ORGANIC LETTERS

Organocatalytic Michael–Knoevenagel–Hetero-Diels–Alder Reactions: An Efficient Asymmetric One-Pot Strategy to Isochromene Pyrimidinedione Derivatives

(2011) Bor-Cherng Hong et al.   ORGANIC LETTERS

Simple and inexpensive threonine-based organocatalysts for the highly diastereo- and enantioselective direct large-scale syn-aldol and anti-Mannich reactions of α-hydroxyacetone

(2011) Chuanlong Wu et al.   TETRAHEDRON-ASYMMETRY

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

Multiple-Organocatalyst-Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted Piperidines

(2010) Yao Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Total Synthesis of (+)-Conicol via Cascade Three-Component Organocatalysis

(2010) Bor-Cherng Hong et al.   ORGANIC LETTERS

Sequential Organocatalytic Stetter and Michael-Aldol Condensation Reaction: Asymmetric Synthesis of Fully Substituted Cyclopentenes via a [1 + 2 + 2] Annulation Strategy

(2010) Bor-Cherng Hong et al.   ORGANIC LETTERS

Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction

(2010) Tatsuya Urushima et al.   ORGANIC LETTERS

One-Pot Enantioselective Syntheses of Iminosugar Derivatives Using Organocatalyticanti-Michael−anti-Aza-Henry Reactions

(2010) Ritsuo Imashiro et al.   ORGANIC LETTERS

Highly Enantioselective Biginelli Reaction Promoted by Chiral Bifunctional Primary Amine-Thiourea Catalysts: Asymmetric Synthesis of Dihydropyrimidines

(2009) Yangyun Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis

(2009) Bryon Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations

(2009) Hayato Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Organocatalytic Four-Component Quadruple Domino Reaction Initiated by Oxa-Michael Addition of Alcohols to Acrolein

(2009) Fang-Lin Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Target-Directed Organocatalysis: A Direct Asymmetric Catalytic Approach to Chiral Propargylic and Allylic Fluorides

(2009) Hao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Asymmetric Multicomponent Resolution: Lipase-Mediated Amidation of a Double Dynamic Covalent System

(2009) Pornrapee Vongvilai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines

(2009) Christopher G. Evans et al.   ORGANIC LETTERS

Microwave-Assisted Organocatalytic Quadruple Domino Reactions of Acetaldehyde and Nitroalkenes

(2009) Dieter Enders et al.   SYNTHESIS-STUTTGART

Asymmetric Synthesis of Polyfunctionalized Mono-, Bi-, and Tricyclic Carbon Frameworksvia Organocatalytic Domino Reactions

(2008) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Controlling the formation of 1 out of 64 stereoisomers using organocatalysis

(2008) Søren Bertelsen et al.   CHEMICAL COMMUNICATIONS

An Enantioselective Biginelli Reaction Catalyzed by a Simple Chiral Secondary Amine and Achiral Brønsted Acid by a Dual-Activation Route

(2008) Junguo Xin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Three-Component Reactions of Pyruvate, Aldehyde and Aniline by Hydrogen-Bonding Catalysts

(2008) Xin Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Lessons from Nature: Biomimetic Organocatalytic Carbon−Carbon Bond Formations§

(2008) Dieter Enders et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Enantioselective Mannich-Type Reaction of Phosphorus Ylides:  Synthesis of ChiralN-Boc-β-Amino-α-methylene Carboxylic Esters

(2008) Yan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole

(2008) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Petasis Reactions Catalyzed by Chiral Biphenols

(2008) Sha Lou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Enantioselective synthesis of the tetrahydro-6H-benzo[c]chromenes via Domino Michael–Aldol condensation: control of five stereocenters in a quadruple-cascade organocatalytic multi-component reaction

(2008) Prakash Kotame et al.   TETRAHEDRON LETTERS

Direct asymmetric three-component Mannich reactions catalyzed by a siloxy serine organocatalyst in water

(2008) Yong-Chua Teo et al.   TETRAHEDRON-ASYMMETRY

Organic Solvent-Free, Enantio- and Diastereoselective, Direct Mannich Reaction in the Presence of Water

(2007) Yujiro Hayashi et al.   ORGANIC LETTERS