Article
Chemistry, Multidisciplinary
R. P. Vivek-Ananth, Karthikeyan Mohanraj, Ajaya Kumar Sahoo, Areejit Samal
Summary: IMPPAT 2.0 is an enhanced and expanded database that compiles manually curated information on 4010 Indian medicinal plants, 17,967 phytochemicals, and 1095 therapeutic uses. It also provides a nonredundant in silico stereo-aware library of 17,967 phytochemicals from Indian medicinal plants.
Review
Food Science & Technology
Janos Vetter
Summary: Carbohydrates, especially glucans, play an important role in the fungal cell wall and have positive biological effects on animals and humans. Different mushrooms contain different types of glucans, with molecular weights ranging from 10^4 to 10^5 Da. The biological effects of glucans are related to the integrity of their tertiary structure.
Article
Computer Science, Artificial Intelligence
Giancarlo Pastor, Inmaculada Mora-Jimenez, Riku Jantti, Antonio J. Caamano
Summary: This paper provides a rigorous examination of sparsity, proposing a broad definition that encompasses various measures useful in practice while still maintaining the fundamental properties of generalized sparsity. It constructs specific measures of sparsity that are successfully applied in complexity analysis and sparse optimization scenarios, with the main objective of facilitating and enhancing the design of innovative sensing technologies.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2022)
Article
Chemistry, Medicinal
Kunlong Li, Siqiang Chen, Xiaoyan Pang, Jian Cai, Xinya Zhang, Yonghong Liu, Yiguang Zhu, Xuefeng Zhou
Summary: This review provides a comprehensive overview of 519 natural products isolated from mangrove sediments-derived microbes (MSM) and their bioactivities. It reveals the structural diversity and medicinal potentials of these compounds. The review also summarizes the pharmacological mechanisms, biosynthetic pathways, and total synthetic strategies of representative compounds. It serves as an important reference for research and further development of natural products from MSM.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Jiawei Sun, He Yang, Wenjun Tang
Summary: This tutorial review summarizes the total synthesis of complex dimeric natural products and discusses various dimerization strategies. By highlighting selected representative examples, it aims to demonstrate the recent tactics of dimerization and provide insights on structural and chemical properties of related natural products, promoting advancements in organic synthesis and biological studies.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Ayesha Rafiq, Tooba Jabeen, Sana Aslam, Matloob Ahmad, Usman Ali Ashfaq, Noor ul Amin Mohsin, Magdi E. A. Zaki, Sami A. Al-Hussain
Summary: The ongoing COVID-19 pandemic has caused global panic due to its continuous evolution and recurring spikes. This article summarizes the literature reports to date on natural products showing inhibitory activity towards the SARS-CoV-2 virus through various approaches, such as in vivo, in vitro, and in silico studies. These natural compounds, mainly extracted from plants, have the potential to combat the deadly viral disease.
Review
Biochemistry & Molecular Biology
Guo-Qing Chen, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Xiaoting Li, Tian Luan
Summary: This review summarizes the structure, biological activity, and mechanism of natural product derivatives containing pyrazine fragments reported from 2000 to September 2023. The results show that pyrazine-modified natural product derivatives have a wide range of biological activities and lower toxicity.
Article
Pharmacology & Pharmacy
Luis D. Gonzalez-Morales, Adriana Moreno-Rodriguez, Lenci K. Vazquez-Jimenez, Timoteo Delgado-Maldonado, Alfredo Juarez-Saldivar, Eyra Ortiz-Perez, Alma D. Paz-Gonzalez, Edgar E. Lara-Ramirez, Lilian Yepez-Mulia, Patricia Meza, Gildardo Rivera
Summary: Cutaneous leishmaniasis (CL) is a global public health problem without available vaccines and with limited effective treatments. This study performed virtual screening of natural products against Leishmania mexicana using molecular docking, and selected four compounds with promising leishmanicidal activity. The ADME-Tox analysis suggested favorable properties for these compounds, and one of them, S-8, exhibited higher activity than the reference drug glucantime.
Review
Chemistry, Multidisciplinary
Xiamin Cheng, Hui Yan, Songhao Pang, Mingjun Ya, Feng Qiu, Pinzhu Qin, Chao Zeng, Yongna Lu
Summary: This review discusses the targeted delivery of medicinal natural products, focusing on the preparation of functional liposomes and the application of liposomal medicinal natural products. It provides useful guidance to enhance targeted therapy of medicinal natural products.
FRONTIERS IN CHEMISTRY
(2022)
Article
Ecology
Gisele P. Nighswander, James S. Sinclair, Adam G. Dale, Jiangxiao Qiu, Basil V. Iannone
Summary: The study found that in ornamental gardens, increasing vegetation clumping and volume in winter can reduce pest abundance, while increasing plant species and spatial variability of species can increase natural enemy abundance and family richness.
LANDSCAPE AND URBAN PLANNING
(2021)
Review
Chemistry, Multidisciplinary
Debobrata Paul, Ashis Kundu, Sanu Saha, Rajib Kumar Goswami
Summary: This feature article highlights total synthesis as a reliable tool for confirming the structure of natural products. Despite advances in spectroscopic techniques, structural misassignments of natural products remain common. Recent case studies have shown that chemical synthesis can be used to revise the structures of natural products.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Man Zhang, Xiaozheng Ou, Hui Shi, Weijuan Huang, Liyan Song, Jianhua Zhu, Rongmin Yu
Summary: In recent years, natural resources have been discovered to be valuable sources of glycoproteins. This review provides a summary and discussion on the development of glycoproteins from natural resources, including isolation methods, purification processes, structural features, and biological activities. The majority of glycoproteins can be isolated through hot water extraction and gel filtration chromatography purification. Various spectroscopic techniques such as UV-visible, FT-IR, and NMR are used to study the physicochemical properties of glycoproteins. Furthermore, natural glycoproteins exhibit significant biological activities such as anti-tumor, anti-oxidant, anti-coagulant, and anti-microbial activities. This review provides a theoretical basis for research on related glycoproteins and offers insights into the potential use of these medicinal resources.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Microbiology
Jian-Long Zhang, Wen-Li Tang, Qing-Rong Huang, You-Zhi Li, Mao-Lian Wei, Lin-Lin Jiang, Chong Liu, Xin Yu, Hong-Wei Zhu, Guo-Zhong Chen, Xing-Xiao Zhang
Summary: Fungi, especially Trichoderma, are essential in drug discovery due to their ability to synthesize diverse specialized metabolites with significant medicinal potential. Recent studies have isolated a large number of secondary metabolites from Trichoderma, showing considerable bioactivities and highlighting their importance in the discovery of new drugs. New strategies for discovering secondary metabolites of Trichoderma in recent years are also discussed.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cetin Bayrak, Parham Taslimi, Namik Kilinc, Ilhami Gulcin, Abdullah Menzek
Summary: In this study, the natural bromophenol butyl 2-(3,5-dibromo-4-hydroxyphenyl)acetate (1) and indene derivatives 34 and 35 were successfully synthesized. Several known natural bromophenols and their derivatives were also synthesized. The synthesized compounds exhibited strong inhibition effects against acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Food Science & Technology
Abdulhakeem S. Alamri, Hammad Saleem, Irfan Pervaiz, Umair Khurshid, Juwairiya Butt, Tahir Ali Chohan, Majid Alhomrani, Marcello Locatelli, Syafiq Asnawi Zainal Abidin, Yasir Nasser H. Alqahtani, Kannan R. R. Rengasamy, Mohamad Fawzi Mahomoodally
Summary: This study explored the phytochemical profiles of E. suberosa, which is traditionally used to treat ulcers and piles. The methanol and dichloromethane extracts from different parts of the plant were analyzed for their bioactive contents and potential therapeutic effects. The results showed that E. suberosa possesses antioxidant and enzyme inhibition properties, validating its traditional uses and suggesting its potential as a functional food.
Review
Chemistry, Multidisciplinary
Yikuan Liu, Xiaona Liu, An Su, Chengtao Gong, Shenwei Chen, Liwei Xia, Chengwei Zhang, Xiaohuan Tao, Yue Li, Yonghe Li, Tulai Sun, Mengru Bu, Wei Shao, Jia Zhao, Xiaonian Li, Yongwu Peng, Peng Guo, Yu Han, Yihan Zhu
Summary: Covalent organic frameworks are crystalline porous materials with designable structures and functions, which can acquire multifunctionalities and have versatile applications in gas separation/storage, catalysis, and optoelectronic devices.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut
Summary: Gene therapy has the potential to revolutionize the treatment of inherited and acquired diseases, but its success rate is currently limited. This review focuses on the obstacles faced by gene therapies in the human body, such as nucleic acid degradation by abundant nucleases, and discusses strategies to reduce degradation and methods to assess nucleic acid integrity.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Chenxi Duan, Chunming Cui
Summary: Low valent group 14 compounds with diazaborolyl substituents exhibit unique structures and reactivity due to the combination of sigma-electron donation and steric hindrance. The modulation of the HOMO-LUMO gap by the diazaborolyl substituents results in novel reaction patterns in the activation of small molecules and inert chemical bonds.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
David E. Salazar Marcano, Nada D. Savic, Kilian Declerck, Shorok A. M. Abdelhameed, Tatjana N. Parac-Vogt
Summary: Metal-oxo clusters have great potential in various fields and can react with biomolecules, making them promising for applications in disease treatment and energy development. They can also be used in the development of inorganic drugs and bioanalytical tools.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Lana K. Moree, Logan A. V. Faulkner, James D. Crowley
Summary: In this tutorial review, the general methods for synthesizing heterometallic metallosupramolecular architectures (MSAs), specifically heterometallic cages, are examined. The intrinsic properties and potential applications of these cages as host-guest systems and reaction catalysts are discussed.
CHEMICAL SOCIETY REVIEWS
(2024)