Article
Biophysics
Keyi Luo, Hang Wu, Yongkang Chen, Jinfeng Li, Lingling Zhou, Fan Yang, Mingxian Huang, Xiao An, Shige Wang
Summary: Radiotherapy is a common treatment for cancer, but tumors with a hypoxic environment often show resistance to it, leading to potential recurrence and metastasis. Therefore, strategies to enhance radiotherapy efficiency are crucial for effective cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jing Wang, Jing Zhao, Fang Ma, Liuyun Gong, Yinliang Lu, Weiping Xiao, Hanmin Tang, Chengyi Gao, Yuetong Chen, Jun Ma, Zhan Gao, Jin Yan, Suxia Han
Summary: A new drug called PAICS has been developed for tumor radiotherapy, combining physical and biological radiosensitization methods. PAICS has shown strong sensitizing ability and controllable safety profile in vivo. Therefore, PAICS could provide a feasible solution to overcome the limitations of physical and biological radiosensitizers, enabling the development of tumor radiotherapy sensitization drugs.
Review
Polymer Science
Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo
Summary: This review provides an overview of functional polymer-based nanomaterials for radiosensitization in recent years. Different types of polymer nanomaterials, including polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels, are discussed in terms of their action mechanisms, drug loading methods, targeting efficiencies, impact on therapeutic effects, and biocompatibility. Polymeric nano-radiosensitizers have the potential to improve the efficacy of radiotherapy and minimize damage to healthy tissues.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Cell Biology
Zeta Chow, Jeremy Johnson, Aman Chauhan, Tadahide Izumi, Michael Cavnar, Heidi Weiss, Courtney M. Townsend, Lowell Anthony, Carrigan Wasilchenko, Matthew L. Melton, Joerg Schrader, B. Mark Evers, Piotr Rychahou
Summary: The study explored a new treatment strategy by combining PI3K/mTOR dual inhibition and radiotherapy to improve outcomes for patients with advanced-stage GEP-NETs. The results demonstrate that scheduled administration of a PI3K/mTOR inhibitor, combined with radiotherapy, can enhance cytotoxicity by promoting the radiosensitivity of NET cells. This finding suggests a promising therapeutic regimen for GEP-NET patients.
Article
Biochemistry & Molecular Biology
Sung-Won Shin, Kyungmi Yang, Miso Lee, Jiyoung Moon, Arang Son, Yeeun Kim, Suha Choi, Do-hyung Kim, Changhoon Choi, Nohyun Lee, Hee Chul Park
Summary: The study found that MFN may overcome radioresistance by alleviating hypoxia and enhancing antitumor immunity in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xianyu Zhu, Wenqi Zhang, Huandong Xiang, Qingchao Chang, Ruixue Liu, Yilong Wan, Ruiting Zhang, Feng Zhao, Yongxing She, Hui Yuan, Jigang Yang, Qiqiang Li, Shanshan Wang, Liang Yan
Summary: This study investigates the use of a phase change material (PCM)-gated Ti3C2Tx nanosheet as a photothermal-responsive drug delivery system for loading natural trans-resveratrol (RSV), aiming to achieve synergistic radiosensitization in a controlled manner. The results demonstrate that the combination of PCM-gated Ti3C2Tx nanosheets with RSV can fabricate photothermal-responsive theranostic systems and effectively enhance radiotherapy against tumor metastasis. This research highlights the importance of metal-based nanomaterials and natural products in enhancing the efficacy of radiotherapy and inhibiting tumor metastasis.
Article
Chemistry, Multidisciplinary
Jiahao Liu, Lina Guo, Ze Mi, Zhenguo Liu, Pengfei Rong, Wenhu Zhou
Summary: A two-step low-dose radiotherapy strategy combined with spherical nucleic acids-based nanomedicine was used to enhance the accumulation and penetration of nanoparticles in tumors. The strategy successfully recruited macrophages into the tumor, which not only served as drug depots but also enhanced extravasation to improve nanoparticle accumulation. Through optimized timing and administration, the delivered nanoparticles promoted a phenotype switch in macrophages, resulting in increased phagocytosis and further enhancing accumulation and penetration. This approach showed significant enhancement of nanoparticles accumulation compared to passive targeting, with efficient deep penetration throughout the tumor tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Medicine, Research & Experimental
Sushmitha Sriramulu, Shivani Thoidingjam, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas, Shyam Nyati
Summary: Radiotherapy is a commonly used cytotoxic therapy for solid cancers, utilizing ionizing radiation to damage DNA and kill tumor cells. Radioresistance is often caused by dysregulated DNA damage repair processes. Radiosensitizers enhance radiation-mediated DNA damage and inhibit DNA repair, leading to accumulation of DNA damages, cell-cycle arrest, and cell death. New molecularly targeted radiosensitizing agents that target key signals in DNA damage response are being evaluated in studies to enhance radiation cytotoxicity and reduce normal tissue toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nanoscience & Nanotechnology
Anqi Zhang, Lei Gao
Summary: Radiotherapy is an important method for treating malignant tumors. Enhancing its therapeutic gain ratio through physical techniques is the current direction of radiotherapy. The combination of hyperthermia and radiotherapy can improve the radiosensitivity of tumor cells and has significant clinical value. Nanomaterials have attracted widespread attention in tumor hyperthermia research and show great potential. This article summarizes the sensitizing mechanisms and effects of gold nanotechnology and provides an overview of the advancements of other nanoparticles in radiation therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ljubica Z. Petrovic, Michael Oumano, Justin Hanlon, Mark Arnoldussen, Igor Koruga, Sayeda Yasmin-Karim, Wilfred Ngwa, Jonathan Celli
Summary: Gold nanoparticles (GNPs) have potential as radiosensitizing and drug delivery agents in cancer treatment. Their localization and time-dependent behavior play a crucial role in their effectiveness. Studies have shown that GNPs initially embed in the extracellular matrix (ECM) and gradually accumulate in cancer cells in 3D cultures. Significant damage enhancement occurs when irradiation is performed after GNPs have accumulated in tumor nodules.
Article
Biotechnology & Applied Microbiology
Haijun Wang, Dianlong Jia, Dandan Yuan, Xiaolei Yin, Fengjiao Yuan, Feifei Wang, Wenna Shi, Hui Li, Li-Min Zhu, Qing Fan
Summary: This study presents a novel approach for translational tumor theranostics by integrating Her2 targeting, diagnosis, and RT sensitization into a single platform using nanocarriers. The developed nanoparticles demonstrated biodegradability and localized production of O-2 in a simulated tumor microenvironment, efficiently inhibited tumor growth, and improved radiosensitization. The incorporation of Z(Her2) endowed these nanoparticles with Her2-dependent binding ability and effective tumor homing and penetration, highlighting their potential for precise enhanced chemo-radiotherapy of Her2-positive ovarian tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Dandan Zhou, Yun Gao, Zhe Yang, Ning Wang, Jianxian Ge, Xiaoyi Cao, Dandan Kou, Yuan Gu, Cang Li, Mohammad Javad Afshari, Ruru Zhang, Can Chen, Ling Wen, Shuwang Wu, Jianfeng Zeng, Mingyuan Gao
Summary: To overcome the drawbacks of monomodal strategies, a combination therapy using lanthanide-doped upconversion nanoparticles (UCNPs) integrated with chlorin e6 (Ce6)-imbedded RBC membrane vesicles as a near-infrared-induced photodynamic therapy (PDT) agent is developed. The nanoagent not only acts as a light transductor for PDT but also as a radiosensitizer for enhanced low-dose radiotherapy (RT). The combination of PDT and RT shows potential for synergistic tumor growth inhibition and cancer metastasis arrest.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Zhongwen Yuan, Xinxin Liu, Jiabao Ling, Guanning Huang, Jiarun Huang, Xueqiong Zhu, Lizhen He, Tianfeng Chen
Summary: By constructing a TME-responsive nanozyme, the redox homeostasis in the tumor microenvironment can be disrupted, resulting in overproduction of ROS and suppression of ROS clearance through reaction with GSH. This enhances the therapeutic efficacy of radiotherapy/chemotherapy.
Article
Engineering, Environmental
Qingxu Song, Gongde Lan, Qian Li, Yang Lin, Xin Chen, Hong Liu, Yufeng Cheng, Yuxia Luan
Summary: Hypofractionated radiotherapy (HRT) is hindered by radio-resistance and inadequate immune activation. Researchers developed an injectable hydrogel platform that enables a cascade amplification of radiosensitization and immune activation to potentiate HRT. The hydrogel releases L-norvaline to spare L-arginine for radiosensitizer nitric oxide (NO) production and uses TLR7/8 agonist to repolarize tumor-associated macrophages, disrupting radio-resistance and immunosuppression. This hydrogel is a promising approach for enhancing HRT and inhibiting tumor growth and metastasis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Medicine, Research & Experimental
Morgan Brisset, Melodie Grandin, Agnes Bernet, Patrick Mehlen, Frederic Hollande
Summary: Dependence receptors play a role in promoting cell survival and positive signaling when activated, but trigger apoptosis when unbound to their ligand. Their abnormal regulation in cancer cells allows them to evade apoptosis and promote tumorigenesis, making them potential targets for therapy.
EMBO MOLECULAR MEDICINE
(2021)
