Article
Pharmacology & Pharmacy
Jana Slovackova, Josef Slavik, Pavel Kulich, Josef Vecera, Ondrej Kovac, Hana Paculova, Nicol Strakova, Radek Fedr, Joao Pedro Silva, Felix Carvalho, Miroslav Machala, Jirina Prochazkova
Summary: This study found that polychlorinated organic pollutants can significantly alter sphingolipid metabolism and cellular morphology in neuronal cells in vitro, affecting neurogenesis. PCB153 was identified as the most prominent deregulator of sphingolipid metabolism, while TCDD and PCB11 also exhibited varying degrees of toxic effects.
Article
Green & Sustainable Science & Technology
Mengdi Gao, Qingyang Wang, Lei Li, Wei Xiong, Conghu Liu, Zhifeng Liu
Summary: This study introduces an emergy-based evaluation method to analyze the environmental impacts and sustainability of stamping systems. Results indicate that the stamping system exhibits high productivity levels and low pollution discharge rates, but its sustainability index is low. Potential improvements in energy consumption, productivity, and environmental impact can be achieved through energy-saving scheduling.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Biology
Peter J. Gawthrop, Michael Pan
Summary: This paper summarises the significant contributions of Edmund Crampin and his group in applying energy-based bond graph methods to biological systems. It motivates the importance of considering energy in biological modelling, introduces bond graphs as a methodology, describes extensions for modelling electrochemical transduction, outlines modular construction of bond graph models, and explains stoichiometric approaches for deriving fundamental properties of reaction networks.
MATHEMATICAL BIOSCIENCES
(2022)
Article
Thermodynamics
Bodin Singpai, Desheng Dash Wu
Summary: This study used an integrative approach to analyze the causes of changes in energy consumption and CO2 emissions in countries involved in the Belt and Road Initiative, identifying labor market, demographic change, and economic situation as main drivers. Higher-income countries perform better in energy and economic efficiencies, but should focus on manufacturing.
Article
Thermodynamics
Ragip Yildirim, Afsin Gungor, Ali Akyuz, Azim Dogus Tuncer
Summary: In this study, a new metric called Environmental Impact Index (EII) was proposed for the environmental analysis of Vapor-Compression Refrigeration (VCR) systems. It integrates the utilization of energy, exergy, and low-emission renewable energy. The EII analysis of a cooling system using different refrigerants showed that Ardahan had the highest EII value, while Şanlıurfa had the lowest. Therefore, when selecting refrigerants for VCR systems, not only the Global Warming Potential (GWP) ratios should be considered, but also the energy, exergy performance, and options with lower emissions.
THERMAL SCIENCE AND ENGINEERING PROGRESS
(2023)
Article
Engineering, Marine
Shawn Hinz, Jennifer Coston-Guarini, Michael Marnane, Jean-Marc Guarini
Summary: This review evaluates the use of environmental DNA (eDNA) in Environmental Impact Assessment (EIA), highlighting key challenges including defining sampling unit and optimal strategy, preliminary assay validation protocols, statistical issues, and unknown fate and transport of DNA fragments in environmental systems.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Editorial Material
Multidisciplinary Sciences
Alison Abbott
Summary: Researchers are interested in understanding the reasons behind cell secretion of vesicles and the functions of these vesicles during delivery.
Article
Environmental Sciences
Andrea Teston, Enedir Ghisi, Igor Catao Martins Vaz, Taylana Piccinini Scolaro, Roni Matheus Severis
Summary: The study used a modular approach to assess the environmental impact of implementing rainwater harvesting systems in urban buildings. The results showed that rainwater harvesting can reduce environmental impacts, particularly in terms of energy and chemical consumption in urban water systems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Green & Sustainable Science & Technology
Victoria Gonzalez, Xingqiu Lou, Ting Chi
Summary: This research analyzes the environmental impact of six fibers in the textile industry, focusing on their agriculture, spinning, weaving, and dyeing stages. The study finds significant differences among these fibers in terms of fossil resource scarcity, global warming, land use, terrestrial ecotoxicity, and water consumption. Silk has the most significant impact in most categories during yarn preparation and spinning, while conventional cotton shows significant impacts in weaving and dyeing. The study contributes to existing LCA research in the textile industry and provides valuable insights for sustainable fashion supply chain management.
Review
Engineering, Biomedical
Payam E. Farahani, Ellen H. Reed, Evan J. Underhill, Kazuhiro Aoki, Jared E. Toettcher
Summary: Cells receive information from their environment and use optogenetic tools to study how they decode signals and produce appropriate responses. Optogenetics helps researchers manipulate protein interactions and activities with precision, leading to a better understanding and engineering of biology.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Green & Sustainable Science & Technology
Gaetana Napolitano, Paola Venditti, Claudio Agnisola, Saverio Quartucci, Gianluca Fasciolo, Maria Teresa Muscari Tomajoli, Eugenio Geremia, Claudio Marcello Catone, Sergio Ulgiati
Summary: Spirulina can improve the growth and wellbeing of fish when used as a supplement in the diet, and growing spirulina in a circular economy context can reduce environmental impacts and enhance fish welfare.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Ecology
Nathaniel T. Marshall, Daniel E. Symonds, Cheryl A. Dean, Gregg Schumer, William Cody Fleece
Summary: Freshwater unionid mussels play a critical role in maintaining freshwater ecosystems, but are heavily imperiled. Environmental DNA (eDNA) offers potential benefits for monitoring these mussels, and this study compared eDNA metabarcoding with traditional methods. The results showed that eDNA could detect a high percentage of sampled species and provide similar estimates of mussel abundances and diversity compared to traditional methods. This demonstrates the practicality of eDNA metabarcoding as a supplemental sampling method for studying diverse mussel communities and improving the detection of threatened species.
FRESHWATER BIOLOGY
(2022)
Article
Genetics & Heredity
Hadi Rezaeeyan, B. Fatemeh Nobakht M. Gh, Masoud Arabfard
Summary: This study investigated COPD, asthma, IPF, and MLD, identifying 22 shared genes and related inflammatory pathways. By understanding the shared genes and pathways, this research can contribute to understanding the pathogenesis of these diseases and designing preventive and therapeutic strategies.
BMC MEDICAL GENOMICS
(2023)
Article
Environmental Sciences
Shahid Ali, Qingyou Yan, Muhammad Irfan, Muhammad Sajjad Hussain, Muhammad Arshad
Summary: The adoption of solar home lighting system (SHLS) has multiple benefits and can be a vital tool in eradicating poverty and improving social lifestyles. This study aims to identify the significant barriers to adopting SHLS in Pakistan and validate the model using data from 271 adopters of SHLS. The findings suggest that overcoming maintenance barriers with professional assistance, government subsidies, ensuring owner satisfaction, and creating awareness through social media are key factors in promoting the adoption of SHLS.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Rachel L. Shapiro, Kevin DeLong, Fareeha Zulfiqar, Davell Carter, Marina Better, Laura M. Ensign
Summary: Vaginal drug delivery systems are preferred for treating female reproductive tract diseases with fewer systemic side effects, but face anatomical and biological barriers. In vitro and ex vivo models are crucial for evaluating these systems. Advanced model systems for other mucosa can inspire future development for the female reproductive tract.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemical Research Methods
Vincenzo Belcastro, Stephane Cano, Diego Marescotti, Stefano Acali, Carine Poussin, Ignacio Gonzalez-Suarez, Florian Martin, Filipe Bonjour, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
Review
Medicine, General & Internal
Julia Hoeng, Serge Maeder, Patrick Vanscheeuwijck, Manuel C. Peitsch
INTERNAL AND EMERGENCY MEDICINE
(2019)
Article
Toxicology
Anita R. Iskandar, Filippo Zanetti, Diego Marescotti, Bjorn Titz, Alain Sewer, Athanasios Kondylis, Patrice Leroy, Vincenzo Belcastro, Laura Ortega Torres, Stefano Acali, Shoaib Majeed, Sandro Steiner, Keyur Trivedi, Emmanuel Guedj, Celine Merg, Thomas Schneider, Stefan Frentzel, Florian Martin, Nikolai Ivanov, Manuel C. Peitsch, Julia Hoeng
ARCHIVES OF TOXICOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyi Zhao, Filippo Zanetti, Lin Wang, Jie Pan, Shoaib Majeed, Hans Malmstrom, Manuel C. Peitsch, Julia Hoeng, Yanfang Ren
JOURNAL OF DENTISTRY
(2019)
Article
Biochemical Research Methods
Diego Marescotti, David Bovard, Moran Morelli, Antonin Sandoz, Karsta Luettich, Stefan Frentzel, Manuel Peitsc, Julia Hoeng
Article
Biochemical Research Methods
Linda Gijzen, Diego Marescotti, Elisa Raineri, Arnaud Nicolas, Henriette L. Lanz, Diego Guerrera, Remko van Vught, Jos Joore, Paul Vulto, Manuel C. Peitsch, Julia Hoeng, Giuseppe Lo Sasso, Dorota Kurek
Article
Toxicology
Albert Giralt, Anita R. Iskandar, Florian Martin, Elisa Moschini, Tomasso Serchi, Athanasios Kondylis, Diego Marescotti, Patrice Leroy, Laura Ortega-Torres, Shoaib Majeed, Celine Merg, Keyur Trivedi, Emmanuel Guedj, Stefan Frentzel, Nikolai Ivanov, Manuel C. Peitsch, Arno C. Gutleb, Julia Hoeng
Summary: The study found that exposure to aerosol from the IQOS MESH device had less cytotoxic effects and did not impact ciliary beating frequency compared to exposure to cigarette smoke in bronchial and alveolar cell cultures.
TOXICOLOGY LETTERS
(2021)
Article
Chemistry, Medicinal
Ainhoa Alzualde, Oihane Jaka, Diogo A. R. S. Latino, Omar Alijevic, Inaki Iturria, Jorge Hurtado de Mendoza, Pavel Pospisil, Stefan Frentzel, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu
Summary: The study found nicotine to be the most effective anxiolytic alkaloid tested, with other natural alkaloids also potentially regulating anxiety.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Immunology
Hasmik Yepiskoposyan, Manuel C. Peitsch, Marja Talikka
Summary: Any stressor that disrupts cellular homeostasis can trigger an inflammatory response, with inflammasomes playing a crucial role in this process. Causal biological network models can be used to interpret transcriptomic data and understand inflammasome activation.
INTERNATIONAL JOURNAL OF INFLAMMATION
(2022)
Article
Biology
Sonia Ouadi, Nicolas Sierro, Simon Goepfert, Lucien Bovet, Gaetan Glauser, Armelle Vallat, Manuel C. Peitsch, Felix Kessler, Nikolai V. IVanov
Summary: This study compares the newly assembled clove genome with Eucalyptus grandis to investigate genome evolution in the Myrtaceae family and identifies potential genes involved in the biosynthesis of eugenol. The findings provide important genomic resources for clove research and the Myrtaceae family.
COMMUNICATIONS BIOLOGY
(2022)
Article
Food Science & Technology
Stephanie Johne, Marco Van der Toorn, Anita R. Iskandar, Shoaib Majeed, Laura O. Torres, Julia Hoeng, Manuel C. Peitsch
Summary: Homemade e-liquids and power-adjustable vaping devices may pose higher risks than commercial formulations and fixed-power devices. This study examined the toxicity of homemade e-liquids containing various chemicals and power settings using human cell cultures. The results showed that certain chemicals in the e-liquids caused cytotoxicity and disrupted epithelial function, while higher power settings generated higher levels of toxic compounds. These findings suggest the need for toxicity assessments for both e-liquid formulations and their aerosols.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catherine Verhaeghe, Marja Talikka, Alain Sewer, Nicolas Sierro, Mehdi Auberson, Dariusz Peric, David Bornand, Remi Dulize, Emmanuel Guedj, Patrick Nef, Sebastien P. Tabruyn, Julia Hoeng, Manuel C. Peitsch, Giuseppe Lo Sasso
Summary: This study investigated the potential anti-inflammatory activities of tobacco alkaloids nicotine and anatabine in a fully humanized UC mouse model. The results showed that nicotine significantly reduced acute colitis symptoms and improved colitis-specific endpoints. Anatabine also demonstrated similar effectiveness, although weaker or not significant. Gene expression analysis provided insights into the possible mechanism by which nicotine attenuated DSS-induced colitis in humanized mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
David Bovard, Marco van der Toorn, Walter K. Schlage, Samuel Constant, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng
Summary: This study confirms the efficacy and safety of Iota-carrageenan nasal spray in preventing SARS-CoV-2 infection. The nasal spray can inhibit the virus from entering and replicating in cells, and it does not cause toxicity or harm to the respiratory epithelium.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemical Research Methods
David Bovard, Antonin Sandoz, Karsta Luettich, Stefan Frentzel, Anita Iskandar, Diego Marescotti, Keyur Trivedi, Emmanuel Guedj, Quentin Dutertre, Manuel C. Peitsch, Julia Hoeng
Article
Medicine, Research & Experimental
Diego Marescotti, Tommaso Serchi, Karsta Luettich, Yang Xiang, Elisa Moschini, Marja Talikka, Florian Martin, Karine Baumer, Remi Dulize, Dariusz Peric, David Bornand, Emmanuel Guedj, Alain Sewer, Sebastien Cambier, Servane Contal, Aline Chary, Arno C. Gutleb, Stefan Frentzel, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2019)