Article
Oncology
Dongbin Ahn, Ji-Hye Kwak, Gil-Joon Lee, Jin-Ho Sohn
Summary: This study evaluated the prevalence and characteristics of human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP), showing an overall prevalence of 14.5%. High-risk HPV types accounted for 75% of all HPV infections, with HPV16 being the most prevalent genotype, accounting for 58.3% of all HPV infections. Patients with OPSP aged <= 45 years, never-smokers, and those with multifocal diseases had a higher prevalence of high-risk HPV infection. These findings could enhance our understanding of HPV infection in OPSP and provide valuable epidemiological data for the management of HPV-associated OPSP.
Article
Oncology
Xinyi Liu, Ping Liu, Rebecca D. Chernock, Krystle A. Lang Kuhs, James S. Lewis, Hua Li, Hiram A. Gay, Wade L. Thorstad, Xiaowei Wang
Summary: This study identified differences in tumor microenvironment (TME) associated with HPV infection in OPSCC, with enrichment of specific cell types in HPV+ and HPV- OPSCCs. By constructing a coexpression network, it was found that HPV+ OPSCCs exhibit elevated immune activities and suppressed extracellular matrix-related activities compared to HPV- OPSCCs. Clinical analysis showed that TME-relevant genes were closely linked to prognosis and therapy response in OPSCC, with results validated in an independent OPSCC cohort.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Genetics & Heredity
David J. Peace, Evgeny Izumchenko, David Sidransky
Summary: A study uses single-cell RNA sequencing to analyze human papillomavirus (HPV)-positive and -negative oropharyngeal squamous cell carcinoma, discovering significant diversity within and between tumors. In HPV-positive tumors, subsets of malignant cells are identified with undetectable HPV expression and decreased HPV-related phenotypes, potentially impacting prognosis and therapeutic response.
Article
Otorhinolaryngology
Alyssa Larish, Linda Yin, Gretchen Glaser, Eric Moore, Jamie Bakkum-Gamez, David Routman, Daniel Ma, Daniel Price, Jeffrey Janus, Katharine Price, Ashish Chintakuntlawar, Michelle Neben-Wittich, Robert Foote, Kathryn Van Abel
Summary: The study found that 37.0% of women with HPV-positive oropharyngeal squamous cell carcinoma had a history of HPV-related anogenital disease, with the cervix being the most common site. Among those with a history, 94.1% required procedures to diagnose or treat HPV lesions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Laurence Bauwens, Aline Baltres, Danny-Joe Fiani, Philippe Zrounba, Guillaume Buiret, Bertrand Fleury, Nazim Benzerdjeb, Vincent Gregoire
Summary: The study aimed to compare the prevalence and distribution of neck node metastases in HPV+ and HPV- oropharyngeal squamous cell carcinoma patients, showing a higher rate of metastases in the HPV+ group.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Otorhinolaryngology
Faris A. Mirza, Christopher Z. Johnson, James Kenneth Byrd, William Greer Albergotti
Summary: This study found that the percentage of locally advanced OPSCC undergoing surgery-based therapy has decreased in both HPV-positive and HPV-negative disease. Factors associated with surgery included younger age, health insurance, and treatment at academic centers.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Lisa M. Pinatti, Hana N. Sinha, Collin Brummel, Christine M. Goudsmit, Timothy J. Geddes, George D. Wilson, Jan A. Akervall, Chad J. Brenner, Heather M. Walline, Thomas E. Carey
Summary: This study found that HPV integration was positively correlated with E6/E7 expression, age at diagnosis, and patient survival. HPV integration may serve as a molecular marker of good prognosis.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Pathology
Nina Gale, Mario Poljak, Metka Volavsek, Lea Hosnjak, Dane Velkavrh, Luka Bolha, Kristina Fujs Komlos, Primoz Strojan, Aleksandar Anicin, Nina Zidar
Summary: The study evaluated the transcriptional activity of high-risk HPV in oropharyngeal squamous cell carcinomas and found that HPV positivity is significant for predicting patient survival.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Oncology
Yaxuan Huang, Yunyun Lan, Zhe Zhang, Xue Xiao, Tingting Huang
Summary: Oropharyngeal squamous cell carcinoma (OPSCC) is a rare malignancy that has seen an increasing incidence in developed countries. Human papillomavirus (HPV) infection has become a major factor in the development of OPSCC. While radiotherapy and surgery are recommended as first-line treatments, chemotherapy is used for advanced cases. Immunotherapy is gaining attention in the treatment of advanced head and neck squamous cell carcinoma (HNSCC). Research on checkpoint inhibitors has shown benefit for metastatic HNSCC patients. The impact of HPV infection on immunotherapeutic efficacy in HNSCC patients is still debated.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Justin R. Shinn, Seth J. Davis, Krystle A. Lang-Kuhs, Sarah Rohde, Xiaowei Wang, Ping Liu, William D. Dupont, Dale Plummer, Wade L. Thorstad, Rebecca D. Chernock, Mitra Mehrad, James S. Lewis
Summary: The study found a high positivity rate of p16 and HPV mRNA in oropharyngeal squamous cell carcinoma patients, with those who had concordant testing results showing higher survival rates. While patients with discordant testing results had survival rates falling between the two concordant groups, there was no significant difference found in outcomes in multivariate analysis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Oncology
Jennifer A. Silver, Sena Turkdogan, Catherine F. Roy, Thavakumar Subramaniam, Melissa Henry, Nader Sadeghi
Summary: The prevalence of oropharyngeal squamous cell carcinoma, associated with human papillomavirus, is increasing in North America. This cancer is distinct from other head and neck cancers due to its occurrence in young populations and high survival rates. Current treatment regimens cause significant long-term toxicities. Studies now focus on patient-reported outcomes and quality of life, instead of mortality-based outcomes. Numerous completed and ongoing trials are investigating alternative therapy regimens or de-escalation strategies to minimize negative secondary effects while maintaining overall survival and disease-free survival.
Article
Medicine, Research & Experimental
Michael G. G. Lin, Alexander Zhu, Paul W. Read, Jonathan Garneau, Christopher McLaughlin
Summary: This study aims to propose a modified surveillance strategy using a novel blood assay to detect circulating tumor-specific HPV DNA, and evaluate the cost implications of avoiding routine imaging and surveillance visits at our institution. The findings suggest that implementing this detection method for HPV positive oropharyngeal squamous cell carcinoma surveillance would reduce costs and unnecessary diagnostic testing.
Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Review
Oncology
Yong Lu, Gary M. Clifford, Christopher K. Fairley, Andrew E. Grulich, Suzanne M. Garland, Fei Xiao, Yuan Wang, Huachun Zou
Summary: This study provides updated information on the prevalence of HPV and p16(INK4a) in oropharyngeal SCC, and highlights the importance of HPV vaccination in preventing a significant proportion of these cases.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Otorhinolaryngology
Farahna Sabiq, Kitty Huang, Adarsh Patel, Robyn Banerjee, Brock Debenham, Harold Lau, David Skarsgard, Guanmin Chen, John T. Lysack, Harvey C. Quon
Summary: In HPV-mediated OPC, a subtype of matted nodes consisting of >= 3 abutting lymph nodes with imaging features of surrounding extranodal extension is associated with worse prognosis. Other imaging patterns did not show significant associations with patient outcomes. Overall inter-rater agreement was substantial (kappa = 0.73).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Engineering, Biomedical
Olivia T. Cheng, Andrew P. Stein, Eric Babajanian, Kathryn R. Hoppe, Shawn Li, Hyungjin Jung, Anish Abrol, Anna Akkus, Mousa Younesi, Ghaith Altawallbeh, Mahmoud A. Ghannoum, Tracey Bonfield, Ozan Akkus, Chad A. Zender
Summary: The study developed and evaluated a novel biologic antimicrobial coating for medical implants, utilizing electrochemically compacted collagen sheets with crosslinked heparin and antibiotics. The results showed that collagen-heparin-antibiotic sheets had larger growth inhibition zones against Pseudomonas aeruginosa compared to collagen-antibiotic alone sheets, with a prolonged elution profile observed via HPLC. This novel local antibiotic delivery system could potentially reduce post-operative infections associated with medical implants in the future.
BIO-MEDICAL MATERIALS AND ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Lindsey Abel, Arda Durmaz, Rong Hu, Colin Longhurst, Andrew M. Baschnagel, Deric Wheeler, Jacob G. Scott, Randall J. Kimple
Summary: Our study showed that fresh human cancer tissue can be cryopreserved and implanted later to establish PDXs. This resource-saving approach allows for tumor profiling before implantation into animals, maximizing the likelihood of future research utilization.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Joshua D. Smith, Jason A. Correll, Jennifer L. Stein, Robbi A. Kupfer, Norman D. Hogikyan, Robert J. Morrison, Andrew P. Stein
Summary: This study evaluated discordance in SARS-CoV-2 detection in hospitalized patients with tracheostomies and found that one-third of patients demonstrated discordant testing results when nasopharyngeal and tracheal specimens were collected within a 48-hour time period. It is recommended to analyze samples from both the nasopharynx and trachea for these patients to reduce the risk of false-negative results.
Article
Oncology
Andrew M. Baschnagel, Jacob H. Elnaggar, Haley J. VanBeek, Ashley C. Kromke, Justin H. Skiba, Saakshi Kaushik, Lindsey Abel, Paul A. Clark, Colin A. Longhurst, Kwangok P. Nickel, Ticiana A. Leal, Shuang G. Zhao, Randall J. Kimple
Summary: The study found enrichment of DDR pathways in many NSCLC patient tumors. M6620 can enhance the effect of radiation on NSCLC brain metastases, leading to improved overall survival in mice when used in combination with radiation.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Florent Carsuzaa, Michel Lapeyre, Vincent Gregoire, Philippe Maingon, Arnaud Beddok, Pierre-Yves Marcy, Julia Salleron, Alexandre Coutte, Severine Racadot, Yoann Pointreau, Pierre Graff, Beth Beadle, Karen Benezery, Julian Biau, Valentin Calugaru, Joel Castelli, Melvin Chua, Alessia Di Rito, Melanie Dore, Pirus Ghadjar, Florence Huguet, Pauline Jardel, Jorgen Johansen, Randall Kimple, Marco Krengli, Sarbani Laskar, Lachlan Mcdowell, Anthony Nichols, Silke Tribius, Izaskun Valduvieco, Chaosu Hu, Xavier Liem, Antoine Moya-Plana, Ida D'onofrio, Upendra Parvathaneni, Vinita Takiar, Ester Orlandi, Amanda Psyrri, George Shenouda, David Sher, Conor Steuer, Xu Shan Sun, Yungan Tao, David Thomson, Mu-Hung Tsai, Noemie Vulquin, Philippe Gorphe, Hisham Mehanna, Sue S. Yom, Jean Bourhis, Juliette Thariat
Summary: International consensus was only achieved for functional deterioration (73.3%), with lower rates for poRT avoidance of flap structures (55.6%), flap definition (41.2%), and tumor spread patterns (11.1%). Recognized the impact of radiation-induced flap fibrosis or atrophy on function, suggesting volume adaptation, and recommended flap avoidance to minimize bone flap osteoradionecrosis.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Immunology
Raghavan Chinnadurai, Paul D. Bates, Keith A. Kunugi, Kwangok P. Nickel, Larry A. DeWerd, Christian M. Capitini, Jacques Galipeau, Randall J. Kimple
Summary: MSCs are being tested as a cell therapy in clinical trials for inflammatory disorders, but suitable preclinical animal models are rare. In this study, two robust animal models of immune pathology were introduced to study the effect of IFN gamma primed bone marrow derived MSCs in acute radiation syndrome and graft versus host disease. The results showed that infused IFN gamma primed allogeneic MSCs protect against lethality from ARS, but not GvHD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
Matthew E. Witek, Neil M. Woody, Hima B. Musunuru, Patrick M. Hill, Poonam Yadav, Adam R. Burr, Huaising C. Ko, Richard B. Ross, Randall J. Kimple, Paul M. Harari
Summary: The study aimed to define the location of initial contralateral lymph node metastasis in patients with oropharynx cancer. The results showed that most patients had a single contralateral LN in level IIA, and the radiation dose to the contralateral parotid gland varied based on the defined CTV. This systematic approach could potentially improve treatment planning for patients with oropharynx cancer.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemistry & Molecular Biology
Samantha T. Bradley, Yong-Syu Lee, Zafer Gurel, Randall J. Kimple
Summary: Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Dysregulation of autophagy can lead to various human diseases and cancers due to its complexity in regulating vital cellular functions. The role of autophagy in cancer development, progression, and treatment is complex, especially given its modulation by most cancer therapies.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Wei Wang, Taja Lozar, Athena E. Golfinos, Denis Lee, Ellery Gronski, Ella Ward-Shaw, Mitchell Hayes, Justine Y. Bruce, Randall J. Kimple, Rong Hu, Paul M. Harari, Jin Xu, Aysenur Keske, Paul M. Sondel, Megan B. Fitzpatrick, Huy Q. Dinh, Paul F. Lambert
Summary: This study investigates the association between high expression of stress keratin 17 (K17) and poor survival and resistance to immunotherapy in human head and neck squamous cell carcinoma (HNSCC). Through the use of a mouse model and patients with HNSCC, it is found that K17 expression plays an important role in regulating the tumor microenvironment and immune responsiveness. Knocking out K17 results in slower tumor growth, increased infiltration of immune cells, and elimination of tumors upon immune-checkpoint blockade treatment. High K17 expression is associated with poor response to pembrolizumab treatment in HNSCC patients.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Graham Campbell, Tiffany A. Glazer, Randall J. Kimple, Justine Yang Bruce
Summary: At the University of Wisconsin, the treatment of head and neck cancer patients is initiated through discussion at the multidisciplinary tumor board. Most patients undergo a laryngeal sparing approach, while those with advanced disease or certain risk factors may undergo total laryngectomy. Radiotherapy, preferably with concurrent cisplatin, is the main treatment approach, with accelerated schedules for patients receiving radiation alone. Significant weight loss, cisplatin use, and radiation to the bilateral neck are identified as major risk factors. Regular follow-up and imaging are conducted to monitor patients for signs of progression.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Grace C. Blitzer, Nicole M. Rogus-Pulia, Cristina Paz, Kwangok P. Nickel, Vanessa L. Cannaday, Cynthia A. Kelm-Nelson, Sailendharan Sudakaran, Richard J. Chappell, Tiffany Glazer, Randall J. Kimple
Summary: Objective Radiation therapy for head and neck cancer can lead to severe xerostomia. This study explored the very late effects of radiation therapy on xerostomia and found that the quality of life of patients with radiation-induced xerostomia was significantly worse. The study also found differences in salivary mucin levels and oral microbiome diversity between patients and healthy controls.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Suman Debnath, Aaron B. Woeppel, Cristina Paz, Nicole Rogus-Pulia, Randall J. Kimple, Georgia A. Malandraki, Bryan W. Boudouris
Summary: Xerostomia often leads to deficits in swallowing, oral communication, and oral hygiene. Current treatments only provide temporary relief. This study shows the use of biocompatible saliva-gels to control artificial saliva release, offering a promising solution for future xerostomia treatment.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Oncology
Noah A. Stueven, DeannaLee M. Beauvais, Rong Hu, Randall J. Kimple, Alan C. Rapraeger
Summary: Previous studies have found that the IGF1R suppresses apoptosis through its coupling with a matrix adhesion receptor complex in HNSCC. In this study, disrupting this complex with a peptide mimetic called SSTNIGF1R inactivates IGF1R and reduces tumor cell survival. Targeting this mechanism with SSTNIGF1R shows promising outcomes in reducing tumor growth in HNSCC.
CANCER RESEARCH COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Seyedehtanaz Saeidzadeh, Kristine Kwekkeboom, Lisa Bratzke, Vijayvardhan Kamalumpundi, Randall J. Kimple
Article
Otorhinolaryngology
Andrew J. Neevel, Joshua D. Smith, Robert J. Morrison, Norman D. Hogikyan, Robbi A. Kupfer, Andrew P. Stein
Summary: Patients recovering from COVID-19 may experience voice, airway, and swallowing issues, which are not exclusive to those who required intubation or tracheostomy. Multidisciplinary laryngology clinics play a crucial role in diagnosing and treating COVID-19-related laryngeal sequelae.