Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Neha Raina, Rakesh Pahwa, Vijay Kumar Thakur, Madhu Gupta
Summary: Polysaccharides have extensive potential applications in wound healing due to their availability, harmlessness, and biodegradability. Polysaccharide-derived hydrogels mimic the natural extracellular matrix and promote cell proliferation, effectively protecting wounds from bacterial infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Rafael Itzhakov, Noy Eretz-Kdosha, Eldad Silberstein, Topaz Alfer, Raanan Gvirtz, Elazar Fallik, Navit Ogen-Shtern, Guy Cohen, Elena Poverenov
Summary: We developed a biocompatible hydrogel for wound healing using natural building blocks. OCS and IdA were used as the building macromolecule and cross-linker, respectively, forming bulk hydrogels with interconnected porous structure. The release rate of hydrogels loaded with Alexa 555 labeled bovine serum albumin and the ameliorating action of epidermal growth factor (EGF) were controlled by the concentration of cross-linker. The hydrogels showed excellent tolerance by human skin, enhanced wound closure, and increased cell proliferation and EGF impact.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Biomaterials
Shengyu Li, Xijin Wu, Ningning Bai, Jianyu Ni, Xianli Liu, Weiye Mao, Lu Jin, Hai Xiang, Huiying Fu, Qiyang Shou
Summary: An oxidized cellulose (OC) sponge with antibacterial properties and biosafety was developed for hemorrhage control and wound healing. The sponge had the ability to expand and absorb water, effectively concentrating blood components. It showed significant biodegradability and minimal irritation to the skin, reducing plasma clotting time and blood loss. The OC sponge also exhibited good biocompatibility and antimicrobial properties, making it a promising material for clinical applications.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Ahmed Mowafy Tafish, Mohamed El-Sherbiny, Ahmed A. Al-Karmalawy, Osama Abd El-Azeem Soliman, Noha Mohamed Saleh
Summary: This study developed novel CAR-loaded phytosomes for wound healing. The optimized formulation showed spherical vesicles with uniform size, enhanced release and permeation properties, and demonstrated significant wound reduction and tissue regeneration in animal experiments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Applied
Quan Yan, Xiaoyan Long, Puxiang Zhang, Wei Lei, Dequn Sun, Xiaoying Ye
Summary: A synergistic hemostatic and antibacterial aerogel dressing based on oxidized Bletilla rhizome polysaccharide and polyvinyl alcohol has been developed. The aerogel exhibits excellent antibacterial and hemostatic capabilities, and promotes wound healing by reducing inflammation and accelerating epithelialization.
CARBOHYDRATE POLYMERS
(2022)
Review
Polymer Science
Maria Morales-Gonzalez, Luis Eduardo Diaz, Carlos Dominguez-Paz, Manuel F. Valero
Summary: Dressings made with polyurethanes have potential applications in wound healing, but current research lacks consideration of different stages of wound healing. The design of polyurethane dressings should better meet the requirements of each stage and address the issue of frequent replacement.
Article
Biochemistry & Molecular Biology
Nam-Gyun Kim, Se-Chang Kim, Tae-Hee Kim, Jae-Young Je, Bonggi Lee, Sang Gil Lee, Young-Mog Kim, Hyun Wook Kang, Zhong-Ji Qian, Namwon Kim, Won-Kyo Jung
Summary: This study investigated the potential application of wound dressing hydrogels in tissue engineering, focusing on their ability to deliver drugs and absorb exudates. The researchers explored the use of polyphenols, specifically Ishophloroglucin A (IPA), as bioactive and cross-linking agents in hydrogel fabrication. By incorporating the extracted IPA into oxidized alginate (OA) and gelatin (GEL) hydrogels, the authors found that the mechanical properties, thermal stability, swelling, and degradation of the hydrogel can be controlled through intermolecular interactions with IPA. The controlled release of IPA also endowed the hydrogel with antioxidant and antimicrobial characteristics, leading to accelerated wound closure and collagen deposition in a mouse wound model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Asma Chetouani, Meriem Elkolli, Hichem Haffar, Henni Chader, Farid Riahi, Tony Varacavoudin, Didier Le Cerf
Summary: Gelatin cross-linked with oxidized pectin shows potential as a scaffold material for tissue engineering, with improved wound healing activity observed in animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Garima Tripathi, Myeongki Park, Hansung Lim, Byong-Taek Lee
Summary: In this study, a novel ACTE aerogel was successfully prepared and showed excellent physicochemical properties for biomedical applications. The aerogel exhibited remarkable platelet adhesion and fibrin network formation abilities, enabling a fast clotting time of less than 60 seconds. In vivo experiments demonstrated that ACT1E10 samples had enhanced skin wound healing compared to ACT1E0 samples, with increased neo-epithelialization, collagen deposition, and extracellular matrix remodeling. Therefore, ACT1E10 aerogel holds promise for skin defect regeneration due to its improved wound-healing ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Dermatology
Minglei Bi, Danyi Li, Jin Zhang
Summary: Ferroptosis is a newly discovered cell death type that differs from other types in terms of morphology, biochemistry, gene, and regulatory mechanisms. It is regulated by mechanisms such as system Xc(-) mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism, and lipid metabolism. Ferroptosis has been found to play a significant role in wound healing, particularly in diabetic, irradiated, and UV-driven wounds. Therefore, understanding and regulating ferroptosis may lead to advancements in wound treatment.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jinhua Chi, Ai Li, Mingyu Zou, Shuo Wang, Chenqi Liu, Rui Hu, Zhiwen Jiang, Wanshun Liu, Rongju Sun, Baoqin Han
Summary: In this study, dopamine was successfully grafted with oxidized sodium alginate to fabricate OSA-DA hydrogels with enhanced biocompatibility and suitable adhesion. The hydrogels exhibited appropriate swelling ratio and adhesion characteristics, and demonstrated satisfactory cytocompatibility in cells and biocompatibility in animals. Moreover, OSA-DA hydrogels showed remarkable promoting effects on angiogenesis and wound healing, making them a potential clinical wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Jennifer Vandooren, Karin Nylander, Erik Martens, Lieve Van Mellaert, Jo Van Damme, Jan Jeroen Vranckx, Patrick Matthys, Tiina Alamae, Mia Phillipson, Triinu Visnapuu, Ghislain Opdenakker
Summary: This study confirmed the in vitro antibacterial effects of the amylose derivative chlorite-oxidized oxyamylose (COAM) against opportunistic bacterial pathogens common to skin wounds. It also demonstrated that COAM modulates macrophage contents in mouse skin wounds.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Robert G. Salomon, Wenzhao Bi
ANTIOXIDANTS & REDOX SIGNALING
(2015)
Article
Chemistry, Medicinal
Hua Wang, Mikhail Linetsky, Junhong Guo, Jaewoo Choi, Li Hong, Amanda S. Chamberlain, Scott J. Howell, Andrew M. Howes, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Young-Woong Kim, Valentin P. Yakubenko, Xiaoxia Z. West, Gabriel B. Gugiu, Kutralanathan Renganathan, Sudipta Biswas, Detao Gao, John W. Crabb, Robert G. Salomon, Eugene A. Podrez, Tatiana V. Byzova
CIRCULATION RESEARCH
(2015)
Article
Hematology
Sudipta Biswas, Liang Xin, Soumya Panigrahi, Alejandro Zimman, Hua Wang, Valentin P. Yakubenko, Tatiana V. Byzova, Robert G. Salomon, Eugene A. Podrez
Article
Chemistry, Medicinal
Junhong Guo, Hua Wang, Borys Hrinczenko, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Junhong Guo, Li Hong, Xiaoxia Z. West, Hua Wang, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Wenzhao Bi, Geeng-Fu Jang, Lei Zhang, John W. Crabb, James Laird, Mikhail Linetsky, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Hua Wang, Mikhail Linetsky, Junhong Guo, Annabelle O. Yu, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Junhong Guo, Mikhail Linetsky, Annabelle O. Yu, Liang Zhang, Scott J. Howell, Heather J. Folkwein, Hua Wang, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2017)
Article
Plant Sciences
Yu-Shiuan Cheng, Wenyuan Yu, Yunfeng Xu, Robert G. Salomon
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, Mikhail D. Linetsky, Robert G. Salomon, Ciro Ramos-Estebanez, Yanming Wang, Xin Yu
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Chemistry, Medicinal
Mikhail Linetsky, Karina S. Bondelid, Sofiya Losovskiy, Vadym Gabyak, Mario J. Rullo, Thomas I. Stiadle, Vasu Munjapara, Priyali Saxena, Duoming Ma, Yu-Shiuan Cheng, Andrew M. Howes, Emeka Udeigwe, Robert G. Salomon
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Gastroenterology & Hepatology
Bakytzhan Bakhautdin, Dola Das, Palash Mandal, Sanjoy Roychowdhury, Jazmine Danner, Katelyn Bush, Katherine Pollard, James W. Kaspar, Wei Li, Robert G. Salomon, Megan R. McMullen, Laura E. Nagy
JOURNAL OF HEPATOLOGY
(2014)
Article
Oncology
Chunying Wu, Xizhen Wang, Nicholas Tomko, Junqing Zhu, William R. Wang, Jinle Zhu, Bin Wang, Yanming Wang, Robert G. Salomon
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2017)
