Article
Biochemistry & Molecular Biology
Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
Summary: The study revealed that CCL8 may promote atherosclerosis by inducing endothelial permeability increase. The NOX2/ROS signaling pathway may be the underlying mechanism for this effect. This research contributes to a deeper understanding of the connection between chemokines and atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Article
Biochemistry & Molecular Biology
Ana Asenjo-Bueno, Elena Alcalde-Estevez, Mariam El Assar, Gemma Olmos, Patricia Plaza, Patricia Sosa, Patricia Martinez-Miguel, Maria Piedad Ruiz-Torres, Susana Lopez-Ongil
Summary: Aging impairs vascular function, potentially due to hyperphosphatemia-induced oxidative stress. Old mice showed an imbalance in oxidant/antioxidant levels in their aortas, but a low-phosphate diet improved vascular function and restored the balance.
Article
Biochemistry & Molecular Biology
Ayaka Yoshinaga, Nobuhiro Kajihara, Daisuke Kukidome, Hiroyuki Motoshima, Takeshi Matsumura, Takeshi Nishikawa, Eiichi Araki
Summary: Hypoglycemia induces mitochondrial ROS production through fatty acid oxidation and leads to increased vascular permeability in retinal endothelial cells. Blocking fatty acid oxidation reduces mtROS production and prevents hypoglycemia-induced vascular permeability in the retina.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Qian Gao, Zhong-Yuan Zhou, Ya-Ning He, Ming-Hui Dong, Zhao-Ning Wang, Hong-Mei Chen
Summary: This study evaluated the toxicity of BDE-47 towards RAW264.7 mouse macrophage cells and found that it caused a decrease in cell viability, an increase in apoptosis, and inhibition of phagocytosis. The mechanisms involved mitochondrial pathway-induced cell apoptosis and oxidative damage. Treatment with an antioxidant reversed the effects, while treatment with a ROS-inducer exacerbated them. These findings highlight the critical role of oxidative damage in BDE-47-induced suppression of immune function.
Article
Plant Sciences
Fang Zhao, Meili Lu, Hongxin Wang
Summary: Chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications in obstructive sleep apnea (OSA). Ginsenoside Rg1 may alleviate CIH-induced vascular endothelial dysfunction through the calpain-1 pathway.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kian Chung Chok, Rhun Yian Koh, Ming Guan Ng, Pei Ying Ng, Soi Moi Chye
Summary: This study investigated the role of melatonin in autophagy pathways in CRC cells and found that melatonin significantly induced autophagy through the ER stress pathway. Overall, melatonin showed potential as an anticancer drug for CRC.
Article
Chemistry, Medicinal
Ah-Won Kwak, Jin-Young Lee, Seung-On Lee, Ji-hye Seo, Jin Woo Park, Yung Hyun Choi, Seung-Sik Cho, Goo Yoon, Mee-Hyun Lee, Jung-Hyun Shim
Summary: This study elucidates the molecular mechanism of Ech-induced apoptosis in both oxaliplatin-sensitive and -resistant CRC cells, showing that Ech exhibits anticancer activity by inducing ROS-mediated apoptosis through the JNK/p38 MAPK signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jinna Chen, Jianwu Zhang, Jiaxiong Wu, Shulei Zhang, Yamin Liang, Bin Zhou, Peng Wu, Dangheng Wei
Summary: Low shear stress induces vascular endothelial cell pyroptosis through the TET2/SDHB/ROS pathway, offering new insights into atherosclerosis. TET2 deficiency results in upregulation of SDHB expression and activity, leading to increased ROS production and mitochondrial injury.ROS scavenger NAC can alleviate VEC pyroptosis induced by SDHB overexpression and TET2 deficiency.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Thomas Jansen, Miroslava Kvandova, Isabella Schmal, Sanela Kalinovic, Paul Stamm, Marin Kuntic, Marc Foretz, Benoit Viollet, Andreas Daiber, Matthias Oelze, John F. Keaney Jr, Thomas Muenzel, Eberhard Schulz, Swenja Kroeller-Schoen
Summary: The study demonstrates that mice with endothelial-specific deletion of alpha 1AMPK have detrimental effects during voluntary exercise training, including increased reactive oxygen species production, eNOS uncoupling, and endothelial dysfunction. These results suggest that endothelial alpha 1AMPK plays a critical role in vascular protection and determines whether the effects of exercise on the vasculature are beneficial or harmful.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jang-Hyuk Yun
Summary: This study focused on the effect of IL-1 beta on pericyte loss and endothelial permeability in diabetic retinopathy. It was found that IL-1 beta induced pericyte apoptosis via NFkB activation under high glucose conditions, leading to increased endothelial permeability. Blocking IL-1 beta/NF-kappa B signaling could be a promising therapeutic target to prevent pericyte loss in diabetic retinopathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Xi Zhao, Guolin Miao, Lijun Zhang, Yuke Zhang, Huanhuan Zhao, Zhelong Xu, Beibei Wang, Lijun Zhang
Summary: The study reveals that C. pneumoniae infection impairs mitochondrial function and increases mitochondrial reactive oxygen species level, promoting the development of atherosclerosis. The antioxidant Mito-TEMPO can inhibit VSMC migration induced by C. pneumoniae infection and reduce the expression of related proteins. Knocking out TLR2 also suppresses these effects, suggesting that targeting antioxidants or TLR2 may be potential therapeutic strategies for C. pneumoniae infection-induced atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
ChengYu Mao, DongJiu Li, En Zhou, JunFeng Zhang, ChangQian Wang, Chao Xue
Summary: Nicotine intake may accelerate atherosclerosis by promoting macrophage pyroptosis and endothelial damage. Therefore, targeting the TXNIP/NLRP3-mediated pyroptotic pathway in macrophages may help alleviate nicotine-induced endothelial damage.
Article
Immunology
Lana Monteiro Meuren, Elisa Beatriz Prestes, Michelle Premazzi Papa, Luiza Rachel Pinheiro de Carvalho, Yasmin Mucuna Mustafa, Leandro Silva da Costa, Andrea T. Da Poian, Marcelo Torres Bozza, Luciana Barros Arruda
Summary: Infection with DENV induces ROS production in HBMECs through activation of mitochondrial function and NADPH oxidase, impacting cell physiology and leading to increased cell death and endothelial permeability. Inhibiting ROS generation by targeting mitochondrial or NOX pathways can reduce virus replication, cell death, and inflammation, presenting potential therapeutic targets for preventing dengue pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)