Article
Toxicology
Christina M. Post, Jason R. Myers, Bethany Winans, B. Paige Lawrence
Summary: Developmental exposure to an AHR-binding chemical can have lasting effects on the function of antiviral CD8+ cytotoxic T lymphocytes (CTL). Diminished DNA methylation, initiated by developmental AHR activation, contributes to reduced polyfunctionality and altered transcriptional program of CD8+ T cells. However, increasing DNA methylation restores function and boosts the number of virus-specific CD8+ T cells. These findings suggest that the deleterious consequences of developmental exposure to environmental chemicals are not permanent and could potentially be improved through interventions.
TOXICOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Review
Clinical Neurology
Kiley Morgart, Joyce Nolan Harrison, Alexander H. Hoon, Anna Maria Wilms Floet
Summary: The groundbreaking work of Robert Anda and Vincent Felitti has highlighted the lifelong impact of adverse childhood experiences on physical, behavioral, and mental health, particularly for children with developmental disabilities. Through advancements in neuroscience and genomics, our understanding of ACEs, wellness, and diseases has improved, providing opportunities for intervention and policy changes in healthcare models.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Engineering, Environmental
Atinuke F. Ojo, Cheng Peng, Jack C. Ng
Summary: Human health risk assessment of PFAS relies on individual substance exposure data, which may not adequately predict the risk from combined exposure. Recent studies show adverse health outcomes of PFAA exposure, highlighting the need for more focus on potential interactions of mixtures within this class of chemicals.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Anika Kaestner, Vanessa Sophie Ernst, Wolfgang Hoffmann, Marco Franze
Summary: The impact of the COVID-19 pandemic on social-emotional developmental risks (SE-DR) of preschool children was studied. The findings showed a decrease in SE-DR among preschoolers after the first wave of the pandemic. However, the study only examined short-term effects and further research is needed to investigate the long-term impact of the pandemic on preschoolers' SE-DR.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Sarah de Voss, Philip Wilson, Sofie Saxild, Gritt Overbeck
Summary: This study investigates the clinical barriers and facilitators of introducing standardized child records with increased focus on psychosocial wellbeing and mental health into child developmental assessments. The results show that clinicians are positive towards increasing the psychosocial focus, but face challenges such as rigid conversations, limited space for parents to raise other issues, and discomfort when addressing unsolvable problems. Implementing standardized child development records with an increased psychosocial focus is feasible but improvements are needed. Parental views should be investigated before further implementation.
Review
Public, Environmental & Occupational Health
Paula Braveman, Tyan Parker Dominguez
Summary: The concept of race emerged in the 1600s with the trans-Atlantic slave trade and has been used to justify slavery, exploitation, denigration, and decimation. Despite scientific evidence against it, a deeply-rooted belief in biological differences based on physical appearance still persists. The term "race" should be abandoned in favor of "ethnic group" to dismantle racism, which influences health and well-being profoundly.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Melissa Kavanaugh, Kathleen Fisher, Jennifer J. Quinlan
Summary: Older adults are vulnerable to foodborne illness and many do not follow safe food handling guidelines. They generally do not perceive themselves as being susceptible to foodborne illness. The Health Belief Model could be expanded to include perceived risk of food contamination.
Review
Biochemistry & Molecular Biology
Udita Basu, Swarup K. Parida
Summary: This review explores the developmental similarities and peculiarities in chickpea and its close relatives pea and Medicago. Key features in chickpea which have potential in yield enhancement have been discussed. However, the developmental particularities and its potential in reforming the yield and nutritional value remain largely unexplored, despite advancements in next-generation sequencing and genomics tools.
PLANT MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov
Summary: Neonatal infections, particularly neonatal sepsis, contribute significantly to mortality rates and require empiric antibiotic therapy. However, the rise of antibacterial resistance has led to the use of antibiotics from higher-risk groups associated with less clinical experience. Choosing the proper dosing regimen is complicated in neonates due to the high variability in the maturation of organ systems. The developmental changes of pharmacokinetic parameters in preterm and full-term infants should be considered in neonatal intensive care units.
Review
Toxicology
Anja Kodila, Nina Franko, Marija Sollner Dolenc
Summary: Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products. Due to safety concerns, industry has started using new BPA analogues, which have similar properties but are less studied. Some BPA analogues have been shown to cause endocrine disruption, with effects on various nuclear receptors. The European Food Safety Authority has reduced the tolerable daily intake of BPA, leading to a comprehensive review of the immunomodulatory activity of BPA analogues, which suggests that they can impact the immune system and contribute to immune-mediated conditions.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Health Care Sciences & Services
Esben R. G. Pedersen, Frantisek Sudzina
Summary: Digital health is gaining attention but not fully integrated into the healthcare system. This study examines citizens' perceptions of digital health and how different health risks influence it. The results show that users' perceptions vary significantly, with high interest in data sharing but low interest in online health communities. The support for digital health is correlated with various health risks, but these risks do not have a uniform relationship with the perceived value of digital health.
Review
Clinical Neurology
Giulia Spoto, Giulia Valentini, Maria Concetta Saia, Ambra Butera, Greta Amore, Vincenzo Salpietro, Antonio Gennaro Nicotera, Gabriella Di Rosa
Summary: The proper connection between pre- and post-synaptic nervous cells relies on various components including membranes, the synaptic cleft, glial cells, and extracellular matrix. Synaptopathy refers to the alteration of mechanisms regulating these synaptic components and is associated with neuropsychiatric disorders. Developmental and Epileptic Encephalopathies (DEEs) are a group of epilepsy syndromes associated with cognitive disturbances, intellectual disability, autistic features, and movement disorders. This review focuses on the pathogenesis of DEEs, particularly on the role of pre-synaptic terminals and potential therapeutic approaches.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Developmental
Lydia Gabriela Speyer, Samuel Neaves, Hildigunnur Anna Hall, Gibran Hemani, Michael Vincent Lombardo, Aja Louise Murray, Bonnie Auyeung, Michelle Luciano
Summary: This study investigated the joint developmental trajectories of internalizing and externalizing problems using parallel process latent class growth analysis, identifying five classes ranging from unaffected to high internalizing and externalizing symptoms. Results showed that affected classes were distinguishable from the unaffected class based on factors such as sex, maternal age, maternal mental health, and child polygenic risk scores. Additionally, phenotypic and polygenic predictors had limited ability to differentiate between different affected classes, suggesting shared risk factors for internalizing and externalizing problems.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Business, Finance
Barbara Bedowska-Sojka, Ender Demir, Adam Zaremba
Summary: The study found that different asset classes exhibit varying levels of sensitivity to geopolitical risk, with bonds and stocks showing strong coherence over longer periods while currencies are affected more in shorter periods. Among these asset classes, green bonds, gold, silver, Swiss franc, and real estate are the most resistant to risk fluctuations.
FINANCE RESEARCH LETTERS
(2022)