Article
Biochemistry & Molecular Biology
Ignazio Restivo, Alessandro Attanzio, Ilenia Concetta Giardina, Francesca Di Gaudio, Luisa Tesoriere, Mario Allegra
Summary: Research shows that exposure to cigarette smoke can induce apoptosis in red blood cells, involving the initiation of DISC formation by p38 MAPK and activation of caspase-8/caspase-3 through ceramide generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Noof Aloufi, Yoon Namkung, Hussein Traboulsi, Emily T. Wilson, Stephane A. Laporte, Barbara L. F. Kaplan, Matthew K. Ross, Parameswaran Nair, David H. Eidelman, Carolyn J. Baglole
Summary: Cannabis is a commonly used illicit product globally and the second most popular smoking plant after tobacco. This study developed a standardized protocol for generating cannabis smoke extract (CaSE) and investigated its impact on cellular mechanisms in vitro. The results showed that CaSE contains cannabinoids and induces an inflammatory response in human lung fibroblasts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhen Chen, Hao Wu, Weiyang Fan, Jiashuo Zhang, Yue Yao, Weiwei Su, Yonggang Wang, Peibo Li
Summary: Extracellular vesicles play a role in maintaining lung homeostasis in cigarette smoke-induced lung diseases. Previous studies have shown that cigarette smoke extract-treated extracellular vesicles promote macrophage polarization, leading to the development of inflammatory responses. This study found that naringenin and cigarette smoke extract co-treated extracellular vesicles significantly inhibit macrophage polarization and the secretion of inflammatory factors. Furthermore, naringenin downregulates miR-21-3p in extracellular vesicles, which targets the PTEN/AKT cascade in macrophages and suppresses M1 macrophage polarization. It also decreases PARP1 expression in extracellular vesicles, potentially suppressing M1 macrophage polarization. These findings provide new pharmacological references for naringenin in the treatment of cigarette smoke-induced lung inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yiming Ma, Lijuan Luo, Xiangming Liu, Herui Li, Zihang Zeng, Xue He, Zijie Zhan, Yan Chen
Summary: The study demonstrates the potential role of PFD in regulating inflammation and oxidative stress induced by cigarette smoke extract, reversing pathological changes and reducing levels of inflammatory factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhen Chen, Hao Wu, Rui Shi, Weiyang Fan, Jiashuo Zhang, Weiwei Su, Yonggang Wang, Peibo Li
Summary: Cigarette smoke-induced inflammation in the lungs, leading to conditions like COPD, is influenced by macrophage polarization and cross-talk between alveolar macrophages and lung epithelial cells via exosomes and miRNAs. This study identified differentially expressed exosomal miRNAs and their target genes involved in regulating macrophage polarization pathways. Furthermore, miR-21-3p and miR-27b-3p were found to play critical roles in promoting macrophage polarization in response to cigarette smoke exposure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physiology
Baishakhi Ghosh, Pratulya Pragadaraju Chengala, Sonya Shah, Daniel Chen, Vaishnavi Karnam, Kai Wilmsen, Bonnie Yeung-Luk, Venkataramana K. Sidhaye
Summary: The airway epithelial barrier plays a crucial role in defending against respiratory diseases, and this study reveals sex-specific differences in the baseline characteristics and response to chronic cigarette smoke exposure in murine tracheal epithelial cells. The findings suggest potential protective roles of planar cell polarity and highlight the importance of recognizing sex-based differences in disease susceptibility and treatment response in respiratory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Serena Di Vincenzo, Claudia Sangiorgi, Maria Ferraro, Marco Buscetta, Chiara Cipollina, Elisabetta Pace
Summary: This study investigated the effects of cigarette smoke on different types of lung cancer cell lines and found that it induces oxidative stress and mitochondrial damage, leading to metabolic reprogramming. Cigarette smoke exposure also downregulates the tumor suppressor FOXO3a, promoting tumor migration and progression.
Article
Multidisciplinary Sciences
Lissethe Palomo-Ligas, Job Estrada-Camacho, Mariana Garza-Ontiveros, Jose Roberto Vargas-Villanueva, Filiberto Gutierrez-Gutierrez, Sendar Daniel Nery-Flores, Jorge Arturo Callas Montoya, Juan Ascacio-Valdes, Lizeth Guadalupe Campos-Muzquiz, Raul Rodriguez-Herrera
Summary: This study aims to investigate the antigiardial effects of pomegranate polyphenols and demonstrate their inhibitory effects on the growth and adhesion capacity of Giardia lamblia trophozoites. Furthermore, pomegranate polyphenols affect the expression and distribution of α-tubulin in the cytoskeleton of Giardia trophozoites. These findings are significant in the development of potential alternative drugs for giardiasis treatment.
Article
Medicine, Research & Experimental
Meng-Yu Zhang, Ying-Xiao Jiang, Yi-Can Yang, Jian-Yu Liu, Chen Huo, Xiu-Li Ji, Yi-Qing Qu
Summary: The study found that cigarette smoke induces inflammation and promotes pyroptosis in 16HBE cells through the ROS/NLRP3/caspase-1 pathway.
Article
Cell Biology
Prathyusha Bagam, Gagandeep Kaur, Dhirendra Pratap Singh, Sanjay Batra
Summary: Cigarette smoking is the primary cause of chronic obstructive pulmonary disease. Oxidative stress induced by cigarette smoke leads to abnormal autophagy, resulting in acute lung injury. The study highlights the crucial role of FOXO1 and FOXO3a in regulating autophagy in response to cigarette smoke exposure.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Toxicology
Amlan Das, Subhendu Chakrabarty, Debasish Nag, Santanu Paul, Arnab Ganguli, Gopal Chakrabarti
Summary: D2O induces autophagy-dependent apoptosis in A549 cells via ROS generation upon microtubule depolymerization and inhibition of PI3K/Akt/mTOR signaling. It augments the efficacy of other microtubule-targeting anticancer drug taxol.
TOXICOLOGY IN VITRO
(2023)
Article
Physiology
Soudipta Pramanik, Alok Kumar Sil
Summary: This study investigates the effects of cigarette smoke extract (CSE) on foam cell formation, demonstrating that CSE treatment leads to lipid accumulation and affects lipid influx and efflux, lysosomal degradation, and mitochondrial utilization. Additionally, the study shows that leucine supplement can significantly reduce CSE-induced foam cell formation.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Neurosciences
Andrew C. Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov, Mark G. LeSage
Summary: Conventional tobacco cigarettes have greater abuse liability compared to non-combusted products, possibly due to higher levels of non-nicotine constituents. This study found that cigarette smoke extract had stronger reinforcing effects than nicotine alone in rats, while non-combusted products had no effect. These findings provide insights into the mechanisms of tobacco addiction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maria Ferraro, Serena Di Vincenzo, Valentina Lazzara, Paola Pinto, Bernardo Patella, Rosalinda Inguanta, Andreina Bruno, Elisabetta Pace
Summary: This study found that long-acting beta 2-agonist formoterol (FO), commonly used for COPD treatment, may exert anti-cancer effects by reversing oxidative stress, inflammation, and epithelial-mesenchymal transition (EMT) processes induced by cigarette smoke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Christy B. M. Tulen, Antoon Opperhuizen, Frederik-Jan van Schooten, Alexander H. V. Remels
Summary: Chronic obstructive pulmonary disease (COPD) is a devastating lung disease mainly caused by cigarette smoking. Aldehydes, such as acetaldehyde, acrolein, and formaldehyde, which are formed during the pyrolysis and combustion of tobacco, have been linked to respiratory toxicity. Mitochondrial dysfunction is suggested to play a crucial role in the pathogenesis of smoking-associated lung diseases like COPD. This review comprehensively discusses the impact of these aldehydes on mitochondrial function and content, as well as the molecular pathways controlling this, in epithelial cells of the airways and lungs.
Article
Nanoscience & Nanotechnology
Pawandeep Kaur, Arun Kumar Sharma, Debasish Nag, Amlan Das, Satabdi Datta, Arnab Ganguli, Vanshita Goel, Satyendra Rajput, Gopal Chakrabarti, Biswarup Basu, Diptiman Choudhury
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Correction
Biochemistry & Molecular Biology
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Article
Biochemistry & Molecular Biology
Amlan Das, Maruthi Kumar Narayanam, Santanu Paul, Pritha Mukhnerjee, Suvranil Ghosh, Debabrata Ghosh Dastidar, Subhendu Chakrabarty, Arnab Ganguli, Biswarup Basu, Mahadeb Pal, Urmi Chatterji, Sushanta K. Banerjee, Parimal Karmakar, Dalip Kumar, Gopal Chakrabarti
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Debabrata G. Dastidar, Amlan Das, Satabdi Datta, Suvranil Ghosh, Mahadeb Pal, Neeraj S. Thakur, Uttam C. Banerjee, Gopal Chakrabarti
Article
Plant Sciences
Santanu Paul, Subhendu Chakrabarty, Suvranil Ghosh, Debasish Nag, Amlan Das, Debabrata Ghosh Dastidar, Moumita Dasgupta, Naibedya Dutta, Mandavi Kumari, Mahadeb Pal, Gopal Chakrabarti
Article
Microbiology
Payel Paul, Poulomi Chakraborty, Ahana Chatterjee, Ranojit K. Sarker, Debabrata Ghosh Dastidar, Taraknath Kundu, Niloy Sarkar, Amlan Das, Prosun Tribedi
Summary: Staphylococcus aureus, a Gram-positive opportunistic microorganism, poses a major threat to public healthcare through biofilm formation. This study found that 1,4-naphthoquinone has significant antimicrobial and antibiofilm activity against Staphylococcus aureus, potentially offering a promising approach to inhibit biofilm formation caused by this pathogen.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Poulomi Chakraborty, Payel Paul, Monika Kumari, Surajit Bhattacharjee, Mukesh Singh, Debasish Maiti, Debabrata Ghosh Dastidar, Yusuf Akhter, Taraknath Kundu, Amlan Das, Prosun Tribedi
Summary: Thymoquinone exhibited significant antibiofilm activity against Pseudomonas aeruginosa by accumulating ROS and inhibiting the expression of quorum sensing gene lasI. Combinatorial application of thymoquinone with other reported antibiofilm agents, such as tryptophan and tetrazine-capped silver nanoparticles, showed enhanced antibiofilm efficiency. The combination of these antibiofilm molecules resulted in ROS accumulation in cells, leading to the inhibition of biofilm formation with minimal cytotoxicity.
FOLIA MICROBIOLOGICA
(2021)
Article
Pharmacology & Pharmacy
Amlan Das, Inamul Haque, Priyanka Ray, Arnab Ghosh, Debasmita Dutta, Mohiuddin Quadir, Archana De, Sumedha Gunewardena, Indranil Chatterjee, Snigdha Banerjee, Scott Weir, Sushanta K. Banerjee
Summary: This study demonstrates that EGCG activates CCN5 to inhibit in vitro cell viability, reverse TNBC cells' stemness, and suppress tumor growth. Additionally, EGCG-loaded nanoparticles are found to be more effective in suppressing tumors compared to free-EGCG.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Microbiology
Payel Paul, Sharmistha Das, Sudipta Chatterjee, Aditya Shukla, Poulomi Chakraborty, Sarita Sarkar, Debasish Maiti, Amlan Das, Prosun Tribedi
Summary: The study investigated the impact of 1,4-naphthoquinone on pre-existing biofilm of Staphylococcus aureus, revealing the key role of extracellular DNA in biofilm integrity. The generation of reactive oxygen species was found to degrade the eDNA and lead to the disintegration of pre-existing biofilm.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Meenu Mehta, Keshav Raj Paudel, Shakti Dhar Shukla, Venkata Sita Rama Raju Allam, Vinod Kumar Kannaujiya, Nisha Panth, Amlan Das, Vipan Kumar Parihar, Amlan Chakraborty, Md Khadem Ali, Niraj Kumar Jha, Dikaia Xenaki, Qian Peter Su, Peter Richard Wich, Jon Adams, Philip Michael Hansbro, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Kamal Dua
Summary: NFicB is a significant player in respiratory diseases, and NFicB decoy ODNs have been utilized in the treatment of chronic inflammatory diseases. However, challenges such as poor pharmacokinetic profile of naked decoy ODNs exist. Structural modifications and nanotechnology offer potential solutions in enhancing the pharmacokinetic profiles of therapeutic substances.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biotechnology & Applied Microbiology
Payel Paul, Poulomi Chakraborty, Ranojit K. Sarker, Ahana Chatterjee, Debasish Maiti, Amlan Das, Sukhendu Mandal, Surajit Bhattacharjee, Debabrata Ghosh Dastidar, Prosun Tribedi
Summary: The study showed that tryptophan can effectively inhibit biofilm formation of Staphylococcus aureus by interfering with its quorum-sensing property and downregulating specific gene expression. Furthermore, tryptophan did not exhibit cytotoxicity at tested concentrations.
Article
Microbiology
Sharmistha Das, Payel Paul, Sudipta Chatterjee, Poulomi Chakraborty, Ranojit K. Sarker, Amlan Das, Debasish Maiti, Prosun Tribedi
Summary: Piperine, a plant-based alkaloid, has shown considerable antimicrobial activity against Staphylococcus aureus, inhibiting its biofilm formation at lower concentrations without compromising microbial growth.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sudipta Chatterjee, Payel Paul, Poulomi Chakraborty, Sharmistha Das, Ranojit Kumar Sarker, Subhasis Sarkar, Amlan Das, Prosun Tribedi
Summary: The study demonstrated that cuminaldehyde has strong antibiofilm activity against Pseudomonas aeruginosa without showing antimicrobial activity. Cuminaldehyde treatment led to the accumulation of cellular reactive oxygen species, inhibiting microbial biofilm formation. Ascorbic acid exposure could restore the biofilm-forming ability of cuminaldehyde-treated cells.
Article
Multidisciplinary Sciences
Dipanjan Ghosh, Debabrata Ghosh Dastidar, Kamalesh Roy, Arnab Ghosh, Debanjan Mukhopadhyay, Nilabja Sikdar, Nidhan K. Biswas, Gopal Chakrabarti, Amlan Das
Summary: This study used computational analysis to predict the potential mechanism by which statin drugs inhibit SARS-CoV-2 pathogenesis. The researchers found that fluvastatin can bind to multiple target proteins of SARS-CoV-2 and exhibits strong antiviral efficacy.
SCIENTIFIC REPORTS
(2022)