期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 21, 期 8, 页码 1586-1593出版社
AMER CHEMICAL SOC
DOI: 10.1021/tx8000576
关键词
-
资金
- NIH [P30-ES10126]
- Formaldehyde Council, Inc
Numerous experiments have demonstrated the genotoxic and mutagenic effects of formaldehyde, including DNA-protein cross-links (DPC). Historic was reported to be involved in the formation of DPC in which the E-amino groups of lysine and exocyclic amino groups of DNA were thought to be cross-linked through multiple step reactions. Using mass spectrometry, the N-terminus of historic and lysine residues located in both the historic N-terminal tail and the globular fold domain were identified as binding sites for formaldehyde in the current study. The observation that only lysine residues without post-translational modification (PTM) can be attacked by formaldehyde indicates that PTM blocks the reaction between lysine and formaldehyde. Additionally, we found that formaldehyde-induced Schiff bases on lysine residues could inhibit the formation of PTM on histone, raising the possibility that formaldehyde might alter epigenetic regulation.
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