Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

Safety, Tolerability and Pharmacokinetic and Pharmacodynamic Learnings from a Double-Blind, Randomized, Placebo-Controlled, Sequential Group First-in-Human Study of the TRPV1 Antagonist, JNJ-38893777, in Healthy Men

(2015) Prasarn Manitpisitkul et al.   CLINICAL DRUG INVESTIGATION

Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF

(2012) Jan Hoffmann et al.   CEPHALALGIA

Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons

(2012) Miles Steven Evans et al.   HEADACHE

The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat

(2012) Duangthip Chatchaisak et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system

(2012) Jan Hoffmann et al.   PAIN

The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches

(2012) Mária Dux et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population

(2011) Oriel Carreño et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Poster Session 1, Sunday 11 September

(2011)   EUROPEAN JOURNAL OF NEUROLOGY

TRPV1 receptor blockade is ineffective in different in vivo models of migraine

(2010) Oliver Summ et al.   CEPHALALGIA

BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study

(2010) Hans-Christoph Diener et al.   CEPHALALGIA

Triptan Therapy in Migraine

(2010) Elizabeth Loder   NEW ENGLAND JOURNAL OF MEDICINE

TRPV1 in migraine pathophysiology

(2010) Jannis E. Meents et al.   TRENDS IN MOLECULAR MEDICINE

Medullary pain facilitating neurons mediate allodynia in headache-related pain

(2009) Rebecca M. Edelmayer et al.   ANNALS OF NEUROLOGY

Intracisternal Injection of Inflammatory Soup Activates the Trigeminal Nerve System

(2009) J Hoffmann et al.   CEPHALALGIA

702 A RANDOMISED, TWO-PERIOD CROSS-OVER STUDY TO INVESTIGATE THE EFFICACY OF THE TRPV1 ANTAGONIST SB-705498 IN ACUTE MIGRAINE

(2009) B. Chizh et al.   EUROPEAN JOURNAL OF PAIN

Serotonin Depletion Increases Nociception-Evoked Trigeminal NMDA Receptor Phosphorylation

(2009) Montree Maneepak et al.   HEADACHE

The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission

(2009) G. A. Lambert et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Neurobiology of migraine

(2009) P.J. Goadsby et al.   NEUROSCIENCE

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

(2009) Prisca Honore et al.   PAIN

Electrophysiological and morphological properties of neurons in the substantia gelatinosa of the mouse trigeminal subnucleus caudalis

(2009) Alexander J. Davies et al.   PAIN

Headache and Multiple Sclerosis: A Population-Based Case-Control Study in Catania, Sicily

(2008) A Nicoletti et al.   CEPHALALGIA

Almotriptan and Its Combination with Aceclofenac For Migraine Attacks: A Study of Efficacy and The Influence of Auto-Evaluated Brush Allodynia

(2008) J Schoenen et al.   CEPHALALGIA

Early vs. Non-Early Intervention in Acute Migraine — ‘Act When Mild (AwM)’. A Double-Blind, Placebo-Controlled Trial of Almotriptan

(2008) PJ Goadsby et al.   CEPHALALGIA

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

(2008) Tony W Ho et al.   LANCET

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Cutaneous allodynia in the migraine population

(2007) Richard B. Lipton et al.   ANNALS OF NEUROLOGY