期刊
JOURNAL OF HEAD TRAUMA REHABILITATION
卷 30, 期 1, 页码 E15-E25出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HTR.0000000000000030
关键词
diffusion tensor imaging (DTI); diffusivity; fractional anisotropy; mild traumatic brain injury (mTBI); military veterans; primary blast; subconcussive blast exposure; white matter
资金
- Department of Defense, Joint Improvised Explosive Device Defeat Organization [51467EGJDO]
- Department of Veterans Health Affairs Rehabilitation Research and Development [RX000389-01]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS086885] Funding Source: NIH RePORTER
- Veterans Affairs [I01RX000389] Funding Source: NIH RePORTER
Objective: Use diffusion tensor imaging to investigate white matter alterations associated with blast exposure with or without acute symptoms of traumatic brain injury (TBI). Participants: Forty-five veterans of the recent military conflicts included 23 exposed to primary blast without TBI symptoms, 6 having primary blast with mild TBI, and 16 unexposed to blast. Design: Cross-sectional case-control study. Main Measures: Neuropsychological testing and diffusion tensor imaging metrics that quantified the number of voxel clusters with altered fractional anisotropy (FA) radial diffusivity, and axial diffusivity, regardless of their spatial location. Results: Significantly lower FA and higher radial diffusivity were observed in veterans exposed to primary blast with and without mild TBI relative to blast-unexposed veterans. Voxel clusters of lower FA were spatially dispersed and heterogeneous across affected individuals. Conclusion: These results suggest that lack of clear TBI symptoms following primary blast exposure may not accurately reflect the extent of brain injury. If confirmed, our findings would argue for supplementing the established approach of making diagnoses based purely on clinical history and observable acute symptoms with novel neuroimaging-based diagnostic criteria that look below the surface for pathology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据