标题
Carbon Nanomaterials for Targeted Cancer Therapy Drugs: A Critical Review
作者
关键词
-
出版物
CHEMICAL RECORD
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-08-30
DOI
10.1002/tcr.201800038
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Specific Oxygenated Groups Enriched Graphene Quantum Dots as Highly Efficient Enzyme Mimics
- (2018) Huan Wang et al. Small
- Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery
- (2017) Pascal Röthlisberger et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Graphene quantum dots for cancer targeted drug delivery
- (2017) Daniela Iannazzo et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy
- (2017) Samer Bayda et al. JOURNAL OF CONTROLLED RELEASE
- Enhanced near-infrared photoacoustic imaging of silica-coated rare-earth doped nanoparticles
- (2017) Yang Sheng et al. Materials Science & Engineering C-Materials for Biological Applications
- Preparation of dual-responsive hybrid fluorescent nano probe based on graphene oxide and boronic acid/BODIPY-conjugated polymer for cell imaging
- (2017) Khoerunnisa et al. Materials Science & Engineering C-Materials for Biological Applications
- Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system
- (2017) Fatemeh Khodadadei et al. Materials Science & Engineering C-Materials for Biological Applications
- Functionalization of 2D transition metal dichalcogenides for biomedical applications
- (2017) Zibiao Li et al. Materials Science & Engineering C-Materials for Biological Applications
- Aminated carbon-based “cargo vehicles” for improved delivery of methotrexate to breast cancer cells
- (2017) Mayank Joshi et al. Materials Science & Engineering C-Materials for Biological Applications
- Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation
- (2017) Kati Erdmann et al. Beilstein Journal of Nanotechnology
- SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer
- (2017) Feng Yin et al. Theranostics
- Thermomechanical Behavior of Polymer Composites Based on Edge-Selectively Functionalized Graphene Nanosheets
- (2017) Ki-Ho Nam et al. Polymers
- Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system
- (2017) Jingjing Liu et al. Biomaterials Science
- Studies on the cytotoxicity of diamond nanoparticles against human cancer cells and lymphocytes
- (2016) Kinga Adach et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Carbon nanotubes as cancer therapeutic carriers and mediators
- (2016) Kuk Hui Son et al. International Journal of Nanomedicine
- Chelerythrine and Fe3O4 Loaded Multi-Walled Carbon Nanotubes for Targeted Cancer Therapy
- (2016) Liangli Cao et al. Journal of Biomedical Nanotechnology
- Rapid dehalogenation of pesticides and organics at the interface of reduced graphene oxide–silver nanocomposite
- (2016) Dibyashree Koushik et al. JOURNAL OF HAZARDOUS MATERIALS
- Immobilization of ruthenium phthalocyanine on silica-coated multi-wall partially oriented carbon nanotubes: Electrochemical detection of fenitrothion pesticide
- (2016) Thiago C. Canevari et al. MATERIALS RESEARCH BULLETIN
- Water-soluble fullerenes for medical applications
- (2016) I. Rašović MATERIALS SCIENCE AND TECHNOLOGY
- Ionic Adsorption and Desorption of CNT Nanoropes
- (2016) Jun-Jun Shang et al. Nanomaterials
- Self-Assembled Hybrids of Fluorescent Carbon Dots and PAMAM Dendrimers for Epirubicin Delivery and Intracellular Imaging
- (2015) Ishita Matai et al. ACS Applied Materials & Interfaces
- Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy
- (2015) Sangiliyandi Gurunathan et al. International Journal of Nanomedicine
- A Green Biosensing Matrix Based on Chitosan and Graphene nanohybrid for the Immobilization of Glucose Oxidase: Synthesis and Property evaluation
- (2015) Sriparna De et al. Journal of Inorganic and Organometallic Polymers and Materials
- Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model
- (2015) Joseph T. Acquaviva et al. Journal of Innovative Optical Health Sciences
- Photoacoustic Imaging Guided Near-Infrared Photothermal Therapy Using Highly Water-Dispersible Single-Walled Carbon Nanohorns as Theranostic Agents
- (2014) Daiqin Chen et al. ADVANCED FUNCTIONAL MATERIALS
- Carbon nanowall scaffold to control culturing of cervical cancer cells
- (2014) Hitoshi Watanabe et al. APPLIED PHYSICS LETTERS
- The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer
- (2014) Zhiwen Zhang et al. BIOMATERIALS
- Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy
- (2014) Jing Bai et al. BIOMATERIALS
- Heteroatom-doped graphene materials: syntheses, properties and applications
- (2014) Xuewan Wang et al. CHEMICAL SOCIETY REVIEWS
- Aqueous stabilisation of carbon-encapsulated superparamagnetic α-iron nanoparticles for biomedical applications
- (2014) Noemí Aguiló-Aguayo et al. DALTON TRANSACTIONS
- Antitumor Therapy Using Nanomaterial-Mediated Thermolysis
- (2014) Alicia Sawdon et al. Journal of Biomedical Nanotechnology
- Biocompatible Graphene Oxide Nanoparticle-Based Drug Delivery Platform for Tumor Microenvironment-Responsive Triggered Release of Doxorubicin
- (2014) Xubo Zhao et al. LANGMUIR
- Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid
- (2014) Julia Tan et al. Drug Design Development and Therapy
- siRNA delivery targeting to the lung via agglutination-induced accumulation and clearance of cationic tetraamino fullerene
- (2014) Kosuke MINAMI et al. Scientific Reports
- Fabrication of Graphene-isolated-Au-nanocrystal Nanostructures for Multimodal Cell Imaging and Photothermal-enhanced Chemotherapy
- (2014) Xia Bian et al. Scientific Reports
- Functional Surface Engineering of C-Dots for Fluorescent Biosensing and in Vivo Bioimaging
- (2013) Changqin Ding et al. ACCOUNTS OF CHEMICAL RESEARCH
- Carbon nanotubes for biomedical imaging: The recent advances
- (2013) Hua Gong et al. ADVANCED DRUG DELIVERY REVIEWS
- Carbon nanotubes in hyperthermia therapy
- (2013) Ravi Singh et al. ADVANCED DRUG DELIVERY REVIEWS
- Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer
- (2013) Jisheng Xiao et al. BIOMATERIALS
- Biocompatible multi-walled carbon nanotube-chitosan–folic acid nanoparticle hybrids as GFP gene delivery materials
- (2013) Xiahui Liu et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Graphene and its derivatives for the development of solar cells, photoelectrochemical, and photocatalytic applications
- (2013) Da Chen et al. Energy & Environmental Science
- A multi-residue method for the determination of pesticides in tea using multi-walled carbon nanotubes as a dispersive solid phase extraction absorbent
- (2013) Xue Hou et al. FOOD CHEMISTRY
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- (2013) Behzad Behnam et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Single-walled carbon nanohorns decorated with semiconductor quantum dots to evaluate intracellular transport
- (2013) Kristen A. Zimmermann et al. JOURNAL OF NANOPARTICLE RESEARCH
- Biological Properties of Carbon Powders Synthesized Using Chemical Vapour Deposition and Detonation Methods
- (2013) M. Batory et al. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Tumor-targeted drug delivery systems based on supramolecular interactions between iron oxide–carbon nanotubes PAMAM–PEG–PAMAM linear-dendritic copolymers
- (2013) Mohsen Adeli et al. Journal of the Iranian Chemical Society
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- (2013) Jonathan Cebik et al. NANOTECHNOLOGY
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- (2013) Omid Akhavan et al. Small
- ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL
- (2013) FEIFAN ZHOU et al. Journal of Innovative Optical Health Sciences
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- (2013) Shun Shen et al. Journal of Materials Chemistry B
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- (2012) Liming Dai ACCOUNTS OF CHEMICAL RESEARCH
- Functionality is Key: Recent Progress in the Surface Modification of Nanodiamond
- (2012) Anke Krueger et al. ADVANCED FUNCTIONAL MATERIALS
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- (2012) Kai Yang et al. ADVANCED MATERIALS
- New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
- (2012) Lingyan Feng et al. ADVANCED MATERIALS
- Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence
- (2012) Changjun Liu et al. BIOMATERIALS
- Laser light triggered-activated carbon nanosystem for cancer therapy
- (2012) Maoquan Chu et al. BIOMATERIALS
- Synthesis and Properties of Polyacrylamide-Based Conducting Gels with Enhanced Mechanical Strength
- (2012) Anfeng Zhu et al. Journal of Macromolecular Science Part B-Physics
- Amphiphilic chitosan modified upconversion nanoparticles for in vivo photodynamic therapy induced by near-infrared light
- (2012) Sisi Cui et al. JOURNAL OF MATERIALS CHEMISTRY
- Nanomaterials formulations for photothermal and photodynamic therapy of cancer
- (2012) Edakkattuparambil Sidharth Shibu et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
- A distinct element method for large scale simulations of carbon nanotube assemblies
- (2012) Igor Ostanin et al. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
- Functionalized multiwalled carbon nanotubes as ultrasound contrast agents
- (2012) L. G. Delogu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Edge-carboxylated graphene nanosheets via ball milling
- (2012) I.-Y. Jeon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemical functionalization of graphene and its applications
- (2012) Tapas Kuila et al. PROGRESS IN MATERIALS SCIENCE
- A clinical study on regional lymphatic chemotherapy using an activated carbon nanoparticle–epirubicin in patients with breast cancer
- (2012) Qian Yang et al. TUMOR BIOLOGY
- Nano-Carbons as Theranostics
- (2012) Zhuang Liu et al. Theranostics
- The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
- (2012) Ying Zhu et al. Theranostics
- Uptake and Translocation Mechanisms of Cationic Amino Derivatives Functionalized on Pristine C60 by Lipid Membranes: A Molecular Dynamics Simulation Study
- (2011) Sebastian Kraszewski et al. ACS Nano
- Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide
- (2011) Bo Tian et al. ACS Nano
- Highly biocompatible multi-walled carbon nanotube–chitosan nanoparticle hybrids as protein carriers
- (2011) Cuiyun Li et al. Acta Biomaterialia
- Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy
- (2011) Satya Prakash et al. ADVANCED DRUG DELIVERY REVIEWS
- Solution-Processable Reduced Graphene Oxide as a Novel Alternative to PEDOT:PSS Hole Transport Layers for Highly Efficient and Stable Polymer Solar Cells
- (2011) Jin-Mun Yun et al. ADVANCED MATERIALS
- Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms
- (2011) Alicia Fernandez-Fernandez et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead
- (2011) Massimo Bottini et al. BIOMACROMOLECULES
- Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study
- (2011) Nanda Gopal Sahoo et al. CHEMICAL COMMUNICATIONS
- Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes
- (2011) Yu-Jen Lu et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment
- (2011) Feng Yang et al. EUROPEAN JOURNAL OF CANCER
- Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia
- (2011) Cornel Iancu International Journal of Nanomedicine
- SiRNA delivery with functionalized carbon nanotubes
- (2011) Amir Khashayar Varkouhi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The properties and applications of nanodiamonds
- (2011) Vadym N. Mochalin et al. Nature Nanotechnology
- Zero-dimensional, one-dimensional, two-dimensional and three-dimensional nanostructured materials for advanced electrochemical energy devices
- (2011) Jitendra N. Tiwari et al. PROGRESS IN MATERIALS SCIENCE
- Assessment of the Evolution of Cancer Treatment Therapies
- (2011) Manuel Arruebo et al. Cancers
- Solution-Processable Graphene Oxide as an Efficient Hole Transport Layer in Polymer Solar Cells
- (2010) Shao-Sian Li et al. ACS Nano
- DNA and carbon nanotubes as medicine
- (2010) William Cheung et al. ADVANCED DRUG DELIVERY REVIEWS
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
- (2010) Jun Fang et al. ADVANCED DRUG DELIVERY REVIEWS
- Detonation Nanodiamond and Onion-Like-Carbon-Embedded Polyaniline for Supercapacitors
- (2010) Igor Kovalenko et al. ADVANCED FUNCTIONAL MATERIALS
- Luminescent Carbon Nanodots: Emergent Nanolights
- (2010) Sheila N. Baker et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Nanodiamonds as intracellular transporters of chemotherapeutic drug
- (2010) Jing Li et al. BIOMATERIALS
- Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors
- (2010) Xiaowen Liu et al. BIOMATERIALS
- Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration
- (2010) Xiaoyong Zhang et al. CARBON
- High-yield exfoliation of three-dimensional graphite into two-dimensional graphene-like sheets
- (2010) Eun-Kyoung Choi et al. CHEMICAL COMMUNICATIONS
- Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs
- (2010) Jinlou Gu et al. CHEMICAL COMMUNICATIONS
- Photothermal Response of Tissue Phantoms Containing Multi-Walled Carbon Nanotubes
- (2010) Saugata Sarkar et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Synthesis of nano onion-like fullerenes by chemical vapor deposition using an iron catalyst supported on sodium chloride
- (2010) Yongzhen Yang et al. JOURNAL OF NANOPARTICLE RESEARCH
- Amorphous Carbon Nanofibers and Their Activated Carbon Nanofibers as Supercapacitor Electrodes
- (2010) V. Barranco et al. Journal of Physical Chemistry C
- Activated carbon nanoparticles or methylene blue as tracer during video-assisted thoracic surgery for lung cancer can help pathologist find the detected lymph nodes
- (2010) Jianxing HE et al. JOURNAL OF SURGICAL ONCOLOGY
- Single-wall carbon nanotubes assisted photothermal cancer therapy: Animal study with a murine model of squamous cell carcinoma
- (2010) Naiyan Huang et al. LASERS IN SURGERY AND MEDICINE
- Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy
- (2010) Kai Yang et al. NANO LETTERS
- High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes
- (2010) Joshua T. Robinson et al. Nano Research
- Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy
- (2010) Kuang-Kai Liu et al. NANOTECHNOLOGY
- The era of carbon allotropes
- (2010) Andreas Hirsch NATURE MATERIALS
- Nanodiamond as the pH-Responsive Vehicle for an Anticancer Drug
- (2010) Bo Guan et al. Small
- Polymers for Drug Delivery Systems
- (2010) William B. Liechty et al. Annual Review of Chemical and Biomolecular Engineering
- In Vivo Near-Infrared Mediated Tumor Destruction by Photothermal Effect of Carbon Nanotubes
- (2009) Hye Kyung Moon et al. ACS Nano
- Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes
- (2009) Supratim Ghosh et al. ACS Nano
- Preparation, Structure, and Electrochemical Properties of Reduced Graphene Sheet Films
- (2009) Longhua Tang et al. ADVANCED FUNCTIONAL MATERIALS
- Carbon nanofiber supercapacitors with large areal capacitances
- (2009) James R. McDonough et al. APPLIED PHYSICS LETTERS
- Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes
- (2009) Xiaoke Zhang et al. BIOMATERIALS
- Analysis of the structure and chemical properties of some commercial carbon nanostructures
- (2009) Jean-Philippe Tessonnier et al. CARBON
- Microwave-Assisted Bromination of Double-Walled Carbon Nanotubes
- (2009) J.-F. Colomer et al. CHEMISTRY OF MATERIALS
- Glycated chitosan as a new non-toxic immunological stimulant
- (2009) Sheng Song et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes
- (2009) Feifan Zhou et al. JOURNAL OF BIOMEDICAL OPTICS
- Fluorescent Carbon Nanoparticles: Synthesis, Characterization, and Bioimaging Application
- (2009) S. C. Ray et al. Journal of Physical Chemistry C
- Synthesis of vertically aligned carbon nanofibres for interfacing with live systems
- (2009) Anatoli V Melechko et al. JOURNAL OF PHYSICS D-APPLIED PHYSICS
- Chemical functionalization of graphene
- (2009) D W Boukhvalov et al. JOURNAL OF PHYSICS-CONDENSED MATTER
- Optical imaging-guided cancer therapy with fluorescent nanoparticles
- (2009) S. Jiang et al. Journal of the Royal Society Interface
- In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1α) using single-walled carbon nanotubes noncovalently coated with siRNA
- (2009) Geoffrey Bartholomeusz et al. Nano Research
- In vitrophotothermal destruction of neuroblastoma cells using carbon nanotubes conjugated with GD2 monoclonal antibody
- (2009) Chung-Hao Wang et al. NANOTECHNOLOGY
- Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents
- (2009) Jin-Woo Kim et al. Nature Nanotechnology
- Promises, facts and challenges for carbon nanotubes in imaging and therapeutics
- (2009) K. Kostarelos et al. Nature Nanotechnology
- Graphene: Status and Prospects
- (2009) A. K. Geim SCIENCE
- Cancer therapy: Small 10/2009
- (2009) Jennifer E. Podesta et al. Small
- Formation of isolated carbon nanofibers with hot-wire CVD using nanosphere lithography as catalyst patterning technique
- (2009) Z.S. Houweling et al. THIN SOLID FILMS
- Evaluation of Solution-Processed Reduced Graphene Oxide Films as Transparent Conductors
- (2008) Héctor A. Becerril et al. ACS Nano
- Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment
- (2008) Z. Liu et al. CANCER RESEARCH
- Carbon-Supported Ruthenium Nanoparticles Stabilized by Methylated Cyclodextrins: A New Family of Heterogeneous Catalysts for the Gas-Phase Hydrogenation of Arenes
- (2008) Audrey Denicourt-Nowicki et al. CHEMISTRY-A EUROPEAN JOURNAL
- Nanodiamond synthesis by pulsed laser ablation in liquids
- (2008) David Amans et al. DIAMOND AND RELATED MATERIALS
- Graphitic Carbon Nanofibers Synthesized by the Chemical Vapor Deposition (CVD) Method and Their Electrochemical Performances in Supercapacitors
- (2008) Denisa Hulicova-Jurcakova et al. ENERGY & FUELS
- Synthesis of Fullerenes and Other Nanomaterials in Arc Discharge
- (2008) G. N. Churilov FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
- Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice
- (2008) Jong-Ho Kim et al. JOURNAL OF CONTROLLED RELEASE
- Feeding Activated Charcoal from Bark Containing Wood Vinegar Liquid (Nekka-Rich) Is Effective as Treatment for Cryptosporidiosis in Calves
- (2008) S. Watarai et al. JOURNAL OF DAIRY SCIENCE
- The structure and reactivity of nanoscale diamond
- (2008) Anke Krueger JOURNAL OF MATERIALS CHEMISTRY
- Structurally Ordered Mesoporous Carbon Nanoparticles as Transmembrane Delivery Vehicle in Human Cancer Cells
- (2008) Tae-Wan Kim et al. NANO LETTERS
- Nano-graphene oxide for cellular imaging and drug delivery
- (2008) Xiaoming Sun et al. Nano Research
- Nanofabricated upconversion nanoparticles for photodynamic therapy
- (2008) Baris Ungun et al. OPTICS EXPRESS
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