期刊
CHEMICAL PHYSICS LETTERS
卷 556, 期 -, 页码 372-375出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cplett.2012.11.079
关键词
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We report Monte Carlo simulations of temperature effects on single-step enzymatic reactions with varied rate constants and diffusion coefficients. For typical systems, where the intrinsic reaction rate is more sensitive to temperature than diffusion, the overall reaction is rate-limited at low temperatures and diffusion-limited at high temperatures. The effective activation energy shifts to a much lower value as temperature is increased. Our results show that the temperature dependence of enzyme-catalyzed reactions within a cell may be only loosely related to a potential energy barrier height. The effective activation energy may be strongly affected by coupling of reaction and diffusion. (C) 2012 Elsevier B. V. All rights reserved.
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