Article
Chemistry, Multidisciplinary
Ben Newell, Wenbo Zhan
Summary: Microneedle-mediated transdermal delivery using nanocarriers can overcome the skin barrier and protect drugs from elimination in skin tissues. Mathematical modelling is used to investigate the drug delivery under various conditions. The results demonstrate the complex dependence of drug accumulation and distribution on the properties of nanocarriers, microneedles, and the environment in different skin layers and blood. Optimizing parameters such as drug release rate, nanocarrier diffusivity, and microneedle length can enhance delivery outcomes. These findings contribute to improving the design of microneedle-nanocarrier drug delivery systems and delivery regimes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Prateek Ranjan Yadav, Muhammad Iqbal Nasiri, Lalitkumar K. Vora, Eneko Larraneta, Ryan F. Donnelly, Sudip K. Pattanayek, Diganta Bhusan Das
Summary: Super-swelling hydrogel-forming microneedles (HFMNs) have gained significant attention as a non-invasive transdermal drug delivery system. A mathematical model incorporating drug binding and experimental validation has been developed, showing promising potential for predictive design and development of super-swelling HFMNs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Xue Jiang, Huanhuan Zhao, Wei Li
Summary: This paper discusses the importance of drug-carrying nanoparticles in disease treatments and the advantages of microneedle-mediated delivery of nanoparticles. It provides an overview of several methods for nanoparticle delivery and the potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Song Li, Dengning Xia, Mark R. Prausnitz
Summary: The study introduces biphasic dissolvable microneedle patches which enhance efficient drug delivery to the skin, reducing drug residue and waste.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Jitong Wang, Jia Zeng, Zhidan Liu, Qin Zhou, Xin Wang, Fan Zhao, Yu Zhang, Jiamiao Wang, Minchen Liu, Ruofei Du
Summary: Arthritis refers to a group of inflammatory joint diseases that severely limit patients' mobility. Rheumatoid arthritis and osteoarthritis, affecting more than 4% of the global population, are the most common clinical conditions. Conventional medication for arthritis often causes gastrointestinal side effects and inconvenience. In recent years, microneedle technology has provided a new approach for transdermal delivery of arthritis drugs with its painless skin perforation and efficient local delivery advantages. This review summarizes different types of arthritis and current therapeutic agents, highlights the development of microneedles in arthritis drug delivery, and discusses the challenges of translating this technology into clinical practice and the marketplace.
Review
Polymer Science
Sipho Mdanda, Philemon Ubanako, Pierre P. D. Kondiah, Pradeep Kumar, Yahya E. Choonara
Summary: Microneedle technology is a versatile, efficient, and promising drug delivery tool with outstanding characteristics suitable for various biomedical fields. Microneedles can penetrate the skin painlessly, enhance drug delivery efficiency, and are expected to become the preferred route for therapeutic injections in the future.
Article
Polymer Science
Kevin Tobin, Jennifer Fiegel, Nicole K. Brogden
Summary: Transdermal delivery of naltrexone (NTX) can be enhanced by using thermosensitive polymer Poloxamer 407 (P407) gel, which may provide more sustained drug release. Microneedle treatment can enhance NTX permeation, and P407 gels show better permeability and more sustained release compared to aqueous solutions.
Article
Engineering, Biomedical
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Geonwoo Kang, Huisuk Yang, Hye Su Min, Jiwoo Shin, Seri Lee, Hyuk Wan Ko, Hyungil Jung
Summary: Liraglutide is a promising option for the treatment of type 2 diabetes mellitus (T2DM), as it reduces the risk of hypoglycemia compared to insulin. However, concerns related to injection prevent regular use. Dissolving microneedles (DMNs) are a potential substitute for injection, but have limitations in drug delivery and maintaining drug activity. This study introduces egg microneedles (EMNs) with functional layered structures that successfully deliver liraglutide with maximum drug activity, making it a good alternative to injections in T2DM treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Deepak Kulkarni, Fouad Damiri, Satish Rojekar, Mehrukh Zehravi, Sarker Ramproshad, Dipali Dhoke, Shubham Musale, Ashiya A. Mulani, Pranav Modak, Roshani Paradhi, Jyotsna Vitore, Md Habibur Rahman, Mohammed Berrada, Prabhanjan S. Giram, Simona Cavalu
Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.
Article
Chemistry, Medicinal
Albatool Sabeeh Al-Badry, Mohammed Hussain Al-Mayahy, David J. Scurr
Summary: Hydrogel microneedles offer a promising approach for delivering drug molecules across the skin in a sustained release manner. The use of hydrogel microneedles containing acyclovir could improve bioavailability and patient compliance while reducing gastrointestinal side effects. The optimal formulation of the hydrogel microneedle array was found to have suitable needle formation, mechanical strength, and drug release over a 24-hour period. The permeation of acyclovir from the hydrogel microneedle array was significantly increased compared to the control, and the array was able to deliver a high percentage of the loading dose over 24 hours.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Instruments & Instrumentation
Krishanu Aich, Tanya Singh, Shweta Dang
Summary: Microneedles have been shown to enhance drug delivery and overcome the drawbacks of traditional injections, offering a significant opportunity for better clinical outcomes. Various types of microneedle designs, including solid, coated, hollow, and polymer microneedles, have been developed to improve drug delivery efficiency. Multiple studies are currently focusing on advancing formulation and microfabrication techniques for the delivery of protein drugs via microneedles.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Jian Chen, Hui Ren, Pan Zhou, Shuai Zheng, Bin Du, Xiaowen Liu, Fei Xiao
Summary: Microneedles have gained significant interest as a transdermal drug delivery route, offering advantages such as nonselective loading capacity, minimal invasiveness, simplicity, and biocompatibility. They can be used to deliver various therapeutics for the treatment of cutaneous diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Cuiping Zhou, Hao Tang, Li Zhang, Hong An, Yunjin Wu, Ding Tang, Jianhua Zhou
Summary: A new replication technique using traditional hypodermic needle tips as templates to produce cost-effective and high-quality polymeric HMN arrays has been developed in this study. The experiments demonstrate that this new technique can produce HMN arrays with excellent consistency, strong penetration force, and high drug loading capacity, showing comparable vaccination efficiency in animal studies.
ADVANCED ENGINEERING MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Suliman Khan, Anwarul Hasan, Farnoosh Attar, Mohammad Mahdi Nejadi Babadaei, Hojjat Alizadeh Zeinabad, Majid Salehi, Morteza Alizadeh, Mahbub Hassan, Hossein Derakhshankhah, Michael R. Hamblin, Qian Bai, Majid Sharifi, Mojtaba Falahati, Timo L. M. ten Hagen
Summary: Microneedle arrays have attracted attention as cancer detection and treatment platforms, delivering active molecules through the skin and improving patient health. They enable controlled release of multiple drugs, optimizing treatment and preventing drug interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Chemical
Qing Han, Mengqing Shi, Linkai Han, Di Liu, Mingwei Tong, Yuxin Xie, Zhonghua Xiang
Summary: Developing highly efficient bifunctional oxygen electrocatalysts is crucial for zinc-air flow batteries. Metal-organic frameworks (MOFs) and covalent organic polymers (COPs) have emerged as promising alternatives due to their designable and controllable atomic-level structures. However, their catalytic performances are limited by conductivity and catalytic activity. In this study, nanosheet FeNi-MOF and iron phthalocyanine rich COP hybrid materials are assembled through the pi-pi stacking effect to create highly efficient bifunctional electrocatalysts. The resulting catalyst exhibits superior catalytic performance and stability, making it a promising candidate for zinc-air flow batteries.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Daria Grigorash, Dmytro Mihrin, Rene Wugt Larsen, Erling H. Stenby, Wei Yan
Summary: The article introduces a new approach to describe the cross-association between molecules, allowing for the simulation of weakly bound molecular complexes with different conformations in mixtures. By incorporating this approach into the equation of state, accurate predictions of vapor-liquid equilibrium and liquid-liquid equilibrium can be made. The new method is validated through experiments on alcohol and acid mixtures, with the results compared to experimental data, demonstrating its accuracy and reliability.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie Maclean, Andrew P. E. York, Axel Zeitler
Summary: This study used terahertz pulsed imaging to investigate the transport process of different solvents into ceramic catalytic materials. The results showed that the heating rate of the samples influenced the water transport rate, while the viscosity of 1-octanol slowed down its transport.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chukwunonso Anyaoku, Sati Bhattacharya, Rajarathinam Parthasarathy
Summary: This study aimed to enhance understanding of settling dynamics in viscoelastic fluids by developing a semi-empirical correlation and a dimensionless ratio, which accurately described the characteristics of settling suspensions.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Antti I. Koponen, Janika Viitala, Atsushi Tanaka, Baranivignesh Prakash, Olli-Ville Laukkanen, Ari Jasberg
Summary: This study focuses on the development of foam application chemicals for the paper and board industry. The research explores the rheology of the polyvinyl alcohol foam used in the process. Measurements were conducted to determine the foam viscosity and slip flow. The results suggest that slip flow contributes significantly to the total flow rate, and the obtained viscosity and slip models provide a solid foundation for industrial processes.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Dalei Sun, Jinghui Cai, Yating Yang, Zhiwu Liang
Summary: In this study, Fe-doped alpha-Bi2O3 catalysts with different Fe/Bi molar ratios were synthesized and utilized in the carbonylation of isobutyl amine with CO2. The results showed that Fe doping significantly enhanced the catalytic abilities of alpha-Bi2O3.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Yuan Tian, Xinxin Wang, Yanrong Liu, Wenping Hu
Summary: This paper predicts the solubility of nitrogen gas in ionic liquids (ILs) using two quantitative structure-property relationship (QSPR) models. By combining machine learning methods and ionic fragments contribution method, the accuracy and reliability of the prediction models are improved.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Liwang Wang, Wei Liu, Pan Yang, Yulong Chang, Xiaoxu Duan, Lingyu Xiao, Yaoming Hu, Jiwei Wu, Liang Ma, Hualin Wang
Summary: This study investigates the effective phase interfacial area (ae) of hydro-jet cyclones at different injection angles. The results show that a 45 degrees upward incidence angle yields the most favorable flow field characteristics for efficient mass transfer. The significant enhancement in ae of the hydro-jet cyclones offers the advantage of reducing equipment volume and cost savings.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chuanjun Wu, Jiangzhi Chen, Jiyue Sun, I-Ming Chou, Shenghua Mei, Juezhi Lin, Lei Jiang
Summary: In this study, the solubility of H2S hydrate in water was measured using Raman spectroscopy. The results showed that the solubility increases with temperature under certain equilibrium conditions, and the solubility also depends on pressure and temperature under different equilibrium conditions. A thermodynamic model based on the van der Waals-Platteeuw theory was developed to predict the solubility, demonstrating its accuracy.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Lorenzo Brivio, Serena Meini, Mattia Sponchioni, Davide Moscatelli
Summary: This study investigates the influence of three main parameters and proposes a kinetic model to predict the optimal operating conditions for high yield of dimethyl terephthalate (DMT) in the chemical recycling process of polyethylene terephthalate (PET).
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Hongju Lin, Fanhui Liao, Yanchang Chu, Mingyu Xie, Lun Pan, Yuanyuan Wang, Lijian Leng, Donghai Xu, Le Yang, Gangfeng Ouyang
Summary: A honeycomb NiCo/C-Na catalyst with a micro-meso-macroporous structure has been fabricated and shown to have significantly higher catalytic activity for the decarboxylation of fatty acids. It also proves to be efficient in upgrading sludge HTL bio-crude, resulting in a biofuel with decreased viscosity and increased density.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Xiaoxian Li, Rui Li, Min Lin, Mingde Yang, Yulong Wu
Summary: A series of coated non-noble metal porous carbon catalysts were synthesized and applied to the aqueous-phase deoxygenation of algal bio-oil. One of the catalysts showed excellent deoxygenation selectivity and catalytic activity at 250 degrees C. The catalyst exhibited good hydrothermal stability and the reaction mechanism was proposed based on product analysis and active site analysis.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
M. V. Chudakova, M. V. Popov, P. A. Korovchenko, E. O. Pentsak, A. R. Latypova, P. B. Kurmashov, A. A. Pimenov, E. A. Tsilimbaeva, I. S. Levin, A. G. Bannov, A. V. Kleymenov
Summary: A series of catalysts with different potassium contents were prepared using solution combustion synthesis and characterized using various techniques. The results showed that the potassium content affected the phase composition and texture of the catalysts. The addition of a small amount of potassium resulted in a change in particle size distribution, leading to higher hydrogen yield. The Ni-1%K2O/Al2O3 catalyst exhibited the highest hydrogen yield at temperatures of 675 and 750 degrees Celsius.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Aliakbar Roosta, Nima Rezaei
Summary: In this study, we modified the electrolyte cubic plus association equation of state (e-CPA EoS) and integrated it with two electrical conductivity models to estimate the electrical conductivity of 11 monovalent electrolyte solutions in water. The modified e-CPA model demonstrated better performance and the hybridization with electrical conductivity models resulted in two predictive models for estimating the electrical conduction of dilute and concentrated electrolyte solutions. These predictive models showed relative average percentage deviations (AARD) of 11.15% and 13.87% over wide ranges of temperature and electrolyte concentration.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Haoren Niu, Jianzheng Wang, Qingzhu Jia, Qiang Wang, Jin Zhao, Fangyou Yan
Summary: A study developed two quantitative structure-property relationship models for the complexation performance of alpha- and beta-cyclodextrins and validated their stability and predictive ability through internal and external validation. The models showed robustness and satisfactory performance, as demonstrated by the experimental results and model validations. These models can effectively predict the binding constants between cyclodextrins and various types of molecules, providing valuable tools for cyclodextrin design.
CHEMICAL ENGINEERING SCIENCE
(2024)