Article
Chemistry, Analytical
Giorgio Ventimiglia, Massimiliano Pesaturo, Alastair Malcolm, Salvatore Petralia
Summary: A silicon lab-on-chip, integrating PCR and hybridization microarray, has been developed for nucleic acid detection. The lab-on-chip shows remarkable sensitivity, multiplexing analysis, and specificity for the detection of target sequences.
Review
Nanoscience & Nanotechnology
Jens Ducree
Summary: This review discusses the challenges and current trends in larger-scale integration of microfluidic systems, highlighting the advantages of centrifugal systems for sample preparation. It also introduces a method using simulation tools for virtual prototyping and design optimization.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Article
Chemistry, Multidisciplinary
Satish Kasturi, Sri Ramulu Torati, Yunji Eom, CheolGi Kim
Summary: This study developed a microfluidic channel and valves integrated electrochemical biosensor for detecting the neurotoxic beta-amyloid (1-42) biomarker. By forming antibody-antigen complexes on gold microelectrode integrated within fluidic chambers and controlling all measurements using pneumatic valves, the biosensor showed a linear response to various beta-amyloid antigen concentrations with enhanced detection limit and potential for efficient detection of other biomarkers.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Analytical
Francesca Costantini, Nicola Lovecchio, Manasa Nandimandalam, Ariana Manglli, Francesco Faggioli, Mara Biasin, Cesare Manetti, Pio Federico Roversi, Augusto Nascetti, Giampiero de Cesare, Domenico Caputo
Summary: In this study, a Lab-on-Chip (LoC)-PCR device called System-on-Glass (SoG) was developed, which integrated thermalization, temperature control, and detection elements on a single glass substrate. Real-time reverse transcriptase PCR of RNA from plant and human viruses was successfully conducted using this device. The LoC-PCR achieved the same detection limit and analysis time as the standard equipment, but with the advantage of portability and faster analysis.
Article
Biochemical Research Methods
Sujit S. Datta, Ilenia Battiato, Martin A. Ferno, Ruben Juanes, Shima Parsa, Valentina Prigiobbe, Enric Santanach-Carreras, Wen Song, Sibani Lisa Biswal, David Sinton
Summary: Transitioning to a sustainable future requires a transformation of energy and environmental technologies. Lab-on-a-chip (LoC) systems can contribute to this transition by studying and developing new processes and materials in areas such as carbon sequestration, hydrogen storage, geothermal energy extraction, bioenergy, critical materials recovery, and water filtration. It is important to engage the LoC community and raise awareness among researchers, industry experts, and policy makers about the potential of LoC approaches in achieving a low-carbon future.
Article
Engineering, Electrical & Electronic
Evangelos Skotadis, Evangelos Aslanidis, George Kokkoris, Emmanouil Artouro Vargkas Kousoulas, Angeliki Tserepi, Dimitris Tsoukalas
Summary: In this paper, a strain-sensing module is used to determine the flow in a microfluidic chip. The module is based on platinum nanoparticle networks and changes its resistance by introducing varying flow rates. The research shows that the module has a competitive limit of detection, low cost, low power requirements, and easy integration with existing microfluidic systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Multidisciplinary Sciences
Amina Farooq, Fezan Hayat, Sobia Zafar, Nauman Zafar Butt
Summary: This study explores the design of an impedimetric microfluidic cytometer on a flexible substrate and compares two microfluidic geometries for their sensitivity. The results show that the microelectrode surface area and the geometry of the sensing volume significantly affect the sensor's output response. Reducing the sensing volume improves pulse amplitude and signal-to-noise ratio. The proposed design demonstrates good detection and differentiation of polystyrene beads and leukemia cells. Additionally, the study presents a feasible approach to achieve irreversible and strong bond strength between thin flexible surfaces in a biochip.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Dammika P. Manage, Jana Lauzon, Linda M. Pilarski, Patrick M. Pilarski, Lynn M. McMullen
Summary: The study compared the detection sensitivity of cassette PCR and a commercial BAX PCR system for detecting E. coli with eae and stx genes. Results showed that cassette PCR had 98.6% concordance with conventional PCR, while BAX PCR only had 65.4% concordance.
Review
Chemistry, Analytical
Mylena Lemes Cunha, Stella Schuster da Silva, Mateus Cassaboni Stracke, Dalila Luciola Zanette, Mateus Nobrega Aoki, Lucas Blanes
Summary: Rapid and low-cost molecular analysis is crucial for early and specific diagnostics. Automated molecular diagnostic devices, such as sample-to-answer microfluidic devices, promise a complete molecular diagnosis system. The extraction process in such devices is laborious but important for sensitive and specific detection. Thus, researching automated or semiautomated extraction methodologies is beneficial for improving extraction procedures.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Samith Hettiarachchi, Gehan Melroy, Amith Mudugamuwa, Peshan Sampath, Charith Premachandra, Ranjith Amarasinghe, Van Dau
Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Computer Science, Theory & Methods
Xing Huang, Tsung-Yi Ho, Wenzhong Guo, Bing Li, Krishnendu Chakrabarty, Ulf Schlichtmann
Summary: Flow-based microfluidic biochips are increasingly utilized in biology and biochemistry for laboratory procedures, with advancements in manufacturing technology allowing for integration of thousands of microvalves into a small platform. Computer-aided design (CAD) in the past decade has attracted research interest for automation of biochip design, enabling designers to explore new chip architectures and simplify complex tasks. Key trends and directions for future research focus on maximizing the potential of microfluidics to advance the industry.
ACM COMPUTING SURVEYS
(2021)
Article
Computer Science, Information Systems
Kaiser Parnamets, Andres Udal, Ants Koel, Tamas Pardy, Nafisat Gyimah, Toomas Rang
Summary: This study presents the construction of a compact empirical mathematical model for predicting the generation speed of droplets in a flow-focusing microfluidic system. By interpreting experimental results, a high-accuracy model suitable for typical applications was obtained. The novelties of this study include the use of a linear approximation model to describe droplet diameter suppression, the introduction of a new shape parameter, and the proposal of a machine learning correction function.
Review
Chemistry, Multidisciplinary
Samaneh Zare Harofte, Madjid Soltani, Saeed Siavashy, Kaamran Raahemifar
Summary: Nowadays, artificial intelligence creates numerous opportunities in the life sciences. Integrating AI with microfluidics can significantly impact various fields of biotechnology.
Article
Biochemical Research Methods
Ning Zhang, Chao Yue, Xiaobo Zhan, Zhi Cheng, Chao Li, Yaohua Du, Feng Tian
Summary: The quantitative analysis of respiratory viruses is important for diagnosis, medicine and prognosis. In this study, a lab-on-a-chip platform combined with an automated control system was used to achieve quantitative analysis of COVID-19 pseudovirus from large-volume nasal swab samples. The method can be extended to other respiratory viruses and sample types.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Cornelia Reuter, Stefanie Hentschel, Antje Breitenstein, Eileen Heinrich, Oliver Aehlig, Thomas Henkel, Andrea Csaki, Wolfgang Fritzsche
Summary: This study successfully established a rapid and selective detection system for identifying human pathogenic water organisms using biomolecular methods, demonstrating its potential application in urban water samples.
WATER AND ENVIRONMENT JOURNAL
(2021)
Article
Multidisciplinary Sciences
Daniel Kraus, Andreas Kleiber, Enrico Ehrhardt, Matthias Leifheit, Peter Horbert, Matthias Urban, Nils Gleichmann, Guenter Mayer, Juergen Popp, Thomas Henkel
Summary: Label-free and gentle separation of cell stages with desired target properties from mixed stage populations is an important research task in modern biotechnological cultivation process. The reported microfluidic sorter system (MSS) significantly increased the purity of target cells in the sorted population.
Article
Engineering, Chemical
Julia Sophie Boeke, Daniel Kraus, Thomas Henkel
Summary: Reliable operation of lab-on-a-chip systems relies on precise and predictable fluid management, with pressure-driven flow control simplifying the process and enabling automation. Predicting the required pressure settings for achieving desired flow rates simplifies control tasks and offers opportunities for creating multi-component laminar flows and droplets.
Article
Chemistry, Analytical
Tamas Vermes, Mark Kielpinski, Thomas Henkel, Miquel A. Pericas, Esther Alza, Angelica Corcuera, Helmut Buschmann, Thomas Goldner, Andreas Urban
Summary: A new automated microfluidic screening assay has been developed in this study, allowing for the measurement of compound EC50 values in very short incubation times and the discrimination of different classes of CAMs. The system also revealed an intermediate CAM-N/A behavior in certain screening compounds.
ANALYTICAL METHODS
(2022)
Article
Materials Science, Multidisciplinary
Chandan Singh, Matthias Thiele, Andre Dathe, Sophie Thamm, Thomas Henkel, Gajjala Sumana, Wolfgang Fritzsche, Andrea Csaki
Summary: A two-step process involving extraction and exchange reactions was used to immobilize gold nanocubes on a glass surface, resulting in improved sensitivity for microfluidic sensing of glucose concentrations.
Article
Chemistry, Analytical
Paul-Gerald Dittrich, Daniel Kraus, Enrico Ehrhardt, Thomas Henkel, Gunther Notni
Summary: The paper investigates the integration of standard imaging flow cytometry with filter-on-chip technology for spatial and spectral measurement, and its application in the development of a multispectral imaging flow cytometry platform. The results demonstrate the potential of this approach for characterizing and classifying bioparticles in-flow, with potential for further applications.
Article
Biochemistry & Molecular Biology
Jana Hildebrandt, Norman Hafner, Daniel Kritsch, Helmar Goerls, Matthias Duerst, Ingo B. Runnebaum, Wolfgang Weigand
Summary: This study investigates the anticancer activity and resistance evasion ability of 17 ruthenium complexes and four osmium analogues with cinnamic acid derivatives as O,S bidentate ligands. The results show that these compounds exhibit high cancer cell selectivity and cytotoxicity without strong effects on DNA damage and cell cycle, suggesting another mode of action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jana Hildebrandt, Norman Haefner, Helmar Goerls, Marie-Christin Barth, Matthias Duerst, Ingo B. Runnebaum, Wolfgang Weigand
Summary: Platinum(II) compounds have attracted significant attention in the development of anticancer drugs, with recent breakthroughs in structure-activity relationships. This study synthesized and characterized 17 complexes with beta-hydroxydithiocinnamic acid esters, revealing promising cytotoxic activity in palladium complexes against platinum-resistant tumors. The identified SARs may guide future research in targeting specific cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Thomas Henkel, Guenter Mayer, Joerg Hampl, Jialan Cao, Linda Ehrhardt, Andreas Schober, Gregor Alexander Gross
Summary: Droplet-based microfluidic screening techniques can be connected to established microtiter plate-based screening and sample management workflows through interfacing tools. A bidirectional sampling interface for sample transfer from wells into droplets and vice versa droplets into wells is achieved using Digital Microfluidic Pipetting Tips (DMPT) and a robotic system.
Article
Chemistry, Multidisciplinary
Micheal K. Farh, Ikrame Louzi, Hassan Abul-Futouh, Helmar Goerls, Norman Haefner, Ingo B. Runnebaum, Wolfgang Weigand
Summary: Ferrocene and its derivatives compounds are important in medicinal organometallic chemistry as antiparasitic or antibacterial agents. This study focuses on the use of dithioester ferrocenyl derivatives to synthesize platinum(II) and palladium(II) complexes with a conserved O,S binding moiety. The synthesized complexes were characterized using various analytical techniques and showed low toxicity towards ovarian cancer cells, unaffected by cisplatin resistance mechanisms. The Pt(II) complexes exhibited the highest activity, with cytotoxic activity increasing with the length of the alkyl chain.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marie-Christin Barth, Norman Haefner, Ingo B. B. Runnebaum, Wolfgang Weigand
Summary: The research explores the anticancer potential of platinum(IV) complexes and investigates the effects of non-steroidal anti-inflammatory drug (NSAID) ligands on their cytotoxicity. The synthesis and characterization of nine platinum(IV) complexes are presented, and their cytotoxic activity is evaluated against ovarian carcinoma cell lines. The most promising complex, Compound 7, induces cell cycle arrest and apoptosis or necrosis in a cell line-dependent manner, acting through a stress response pathway involving p21, CHOP, and ATF3 genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Daniel Kraus, Julia Sophie Boeke, Enrico Ehrhardt, Thomas Henkel
Summary: This article introduces a method called Multispectral Imaging Flow Cytometry (MIFC) for tracking morphological and compositional changes of single cells. By using multispectral imaging, the amount and distribution of substances inside the cells can be measured, which has important applications in cell cultivation processes.
MICRO AND NANO ENGINEERING
(2022)
Article
Chemistry, Inorganic & Nuclear
Marie-Christin Barth, Stefanie Lange, Norman Haefner, Nico Ueberschaar, Helmar Goerls, Ingo B. Runnebaum, Wolfgang Weigand
Summary: Here, new oxaliplatin-based platinum(IV) complexes were synthesized through reaction with DSC-activated thiols via thiocarbonate linkage. This synthetic strategy expands the range of biologically active compounds and the cytotoxicity of these complexes was evaluated against various ovarian carcinoma cell lines.
DALTON TRANSACTIONS
(2022)
Review
Biochemical Research Methods
Andreas Kleiber, Daniel Kraus, Thomas Henkel, Wolfgang Fritzsche
Summary: Conventional flow cytometry (FC) has evolved as a powerful measurement method in clinical diagnostics, biology, life sciences and healthcare within the last decades. Imaging flow cytometry (IFC) extends the power of traditional FC by adding high resolution optical and spectroscopic information. Tomographic imaging flow cytometry (tIFC) was developed to access 3D information about the target particles, aiming to visualize surfaces and internal structures in a holistic way.
Proceedings Paper
Optics
Paul-Gerald Dittrich, Daniel Kraus, Thomas Henkel, Jurgen Popp, Maik Rosenberger, Gunther Notni
Summary: The study extended imaging flow cytometry (IFC) with snapshot-mosaic cameras for in-flow characterization of bioparticles, allowing for analysis and counting of single cells and whole cell populations. The use of spatial and spectrally resolving snapshot-mosaic cameras and real time capable multivariate data processing expands the possibilities for automated analysis of mixed bioparticle populations. The microalgae Haematococcus pluvialis (HP) was used in the experiments to demonstrate the usability of the system.
MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XIX
(2021)
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)