Article
Multidisciplinary Sciences
Tyler Sano, Ravipa Losakul, Holger Schmidt
Summary: Integrated optofluidic devices, combining microfluidics and photonic structures, have gained high interest for rapid biosensor devices. Researchers demonstrated a polydimethylsiloxane-based device with two on-chip optofluidic laser cavities, enabling simultaneous detection of multiple fluorescent targets.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Physical
Zuzana Petrusova, Zdenek Slouka, Lucie Vobecka, Petr Polezhaev, Pavel Hasal, Michal Pribyl, Pavel Izak
Summary: This article reviews the progress in microfluidics and membrane chiral separation technologies over the last two decades and discusses their advantages and characteristics in producing enantiomerically pure compounds. Efforts to integrate synthesis and membrane separation into a microfluidic platform are evaluated, identifying the limiting factors that need to be overcome before these platforms can be fully utilized in the industry.
CATALYSIS REVIEWS-SCIENCE AND ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Samith Hettiarachchi, Gehan Melroy, Amith Mudugamuwa, Peshan Sampath, Charith Premachandra, Ranjith Amarasinghe, Van Dau
Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Chemistry, Multidisciplinary
Samaneh Zare Harofte, Madjid Soltani, Saeed Siavashy, Kaamran Raahemifar
Summary: Nowadays, artificial intelligence creates numerous opportunities in the life sciences. Integrating AI with microfluidics can significantly impact various fields of biotechnology.
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Article
Chemistry, Multidisciplinary
Alexandra C. Sun, Daniel J. Steyer, Richard I. Robinson, Carol Ginsburg-Moraff, Scott Plummer, Jinhai Gao, Joseph W. Tucker, Dirk Alpers, Corey R. J. Stephenson, Robert T. Kennedy
Summary: In the field of drug discovery, high-throughput experimentation techniques are used to optimize reactions and generate drug compound libraries quickly for evaluation. This study presents a segmented flow mass spectrometry-based platform to explore photoredox reactions in early-stage drug discovery. The technology enables fast analysis of photochemical reactions and evaluation of synthesized analogs, expanding the capabilities of photoredox catalysis in drug discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Analytical
Ruth Shinar, Joseph Shinar
Summary: Organic electronics (OE) technology has matured in displays and is advancing in solid-state lighting applications. It also shows great potential in (bio)chemical sensing, imaging, in vitro cell monitoring, and other biomedical diagnostics. OE devices, such as organic LEDs, organic and hybrid perovskite-based photodetectors, and organic thin-film transistors, are utilized in these applications. The integration of compact and sensitive OE devices with microfluidic channels and lab-on-a-chip (LOC) structures is very promising.
Article
Chemistry, Analytical
Daphika S. Dkhar, Rohini Kumari, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Summary: Lab-on-a-chip (LOC) biosensors have attracted research interest for their potential in personal healthcare and disease diagnostics. This review discusses various fabrication methods and techniques for designing LOC sensing devices, as well as the types of transduction systems that play a crucial role in sensing. The detection of analytes, including small molecules, macromolecules, and cells, is comprehensively reviewed with illustrations and tables.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Article
Engineering, Chemical
Julia Sophie Boeke, Daniel Kraus, Thomas Henkel
Summary: Reliable operation of lab-on-a-chip systems relies on precise and predictable fluid management, with pressure-driven flow control simplifying the process and enabling automation. Predicting the required pressure settings for achieving desired flow rates simplifies control tasks and offers opportunities for creating multi-component laminar flows and droplets.
Review
Chemistry, Physical
Robert Bogdanowicz, Martin Jonsson-Niedziolka, Elizaveta Vereshchagina, Anna Dettlaff, Suchanat Boonkaew, Mattia Pierpaoli, Paul Wittendorp, Shruti Jain, Frode Tyholdt, Jacob Thomas, Pawel Wojcik
Summary: This review discusses recent advancements in electrochemical devices used for photo- and spectroelectrochemical investigations. It focuses on the miniaturization of devices, such as nanointerdigitated complementary metal-oxide-semiconductor devices, micro- and nano-porous silicon membranes, and microoptoelectromechanical spectroscopy or optical microcavities. Polymer-based devices are also evaluated for their efficiency in various applications, including bioelectrochemical systems, biocatalysis, photochemical synthesis, and single nanoparticle spectroelectrochemistry. The review also discusses the challenges and future prospects of microfluidic and spectroelectrochemical devices.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Vahid Nasrollahi, Panagiotis Kassanos, Stefan Dimov, Daniele Vigolo, Ali K. Yetisen
Summary: In this article, femtosecond laser writing is used to engrave microfluidic networks into commercial contact lenses, achieving rapid and precise processing. The ablation process and tear flow within microfluidic structures are evaluated experimentally and computationally. Functional microfluidic components such as flow valves, resistors, and two applications, a tear volume sensor and a tear uric acid sensor, are introduced, providing painless alternatives with reduced contamination risks.
Article
Environmental Sciences
Matt Mowlem, Alexander Beaton, Robin Pascal, Allison Schaap, Socratis Loucaides, Sam Monk, Andrew Morris, Christopher L. Cardwell, Sara E. Fowell, Matthew D. Patey, Patricia Lopez-Garcia
Summary: A new product line utilizing in situ lab on chip technology has been introduced for high accuracy measurements of water chemistry parameters, even in deep sea environments. Commercially available sensors include Nitrate, Nitrite, Phosphate, Silicate, Iron, and pH sensors. The technology is adaptable for a wide range of environmental measurements, particularly for chemical and biological parameters that require reagents.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Computer Science, Hardware & Architecture
Xing Huang, Youlin Pan, Zhen Chen, Wenzhong Guo, Lu Wang, Qingshan Li, Robert Wille, Tsung-Yi Ho, Ulf Schlichtmann
Summary: Due to the complexity of chip architecture and assay protocol, traditional methods for designing continuous-flow microfluidic lab-on-a-chip systems have serious gaps between different steps, leading to design failure. This article proposes a novel "one-pass design paradigm" that integrates all design steps seamlessly, eliminating the gaps and generating optimized biochip architectures without the need for design adjustments and modifications. Experimental results demonstrate the effectiveness of the proposed automation flows.
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Emanuele Piccinno, Anna Grazia Monteduro, Francesco Dituri, Silvia Rizzato, Gianluigi Giannelli, Giuseppe Maruccio
Summary: The study validated a miniaturized on-chip platform for real-time, non-destructive cell proliferation assays and drug screening, comparing its effectiveness with the traditional 96-well plate assay. Results showed the new platform's efficacy comparable to the standard method, with advantages in reagent consumption, operator time, and costs, potentially accelerating drug development processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Vera Dugandzic, Stephan Kupfer, Martin Jahn, Thomas Henkel, Karina Weber, Dana Cialla-May, Juergen Popp
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Chemistry, Analytical
Abdullah S. Mondol, Milind D. Patel, Jan Rueger, Clara Stiebing, Andreas Kleiber, Thomas Henkel, Jurgen Popp, Iwan W. Schie
Article
Biotechnology & Applied Microbiology
Cornelia Reuter, Nicole Slesiona, Stefanie Hentschel, Oliver Aehlig, Antje Breitenstein, Andrea Csaki, Thomas Henkel, Wolfgang Fritzsche
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Chemistry, Analytical
Mark Kielpinski, Oliver Walther, Jialan Cao, Thomas Henkel, J. Michael Koehler, G. Alexander Gross
Article
Environmental Sciences
Cornelia Reuter, Stefanie Hentschel, Antje Breitenstein, Eileen Heinrich, Oliver Aehlig, Thomas Henkel, Andrea Csaki, Wolfgang Fritzsche
Summary: This study successfully established a rapid and selective detection system for identifying human pathogenic water organisms using biomolecular methods, demonstrating its potential application in urban water samples.
WATER AND ENVIRONMENT JOURNAL
(2021)
Article
Multidisciplinary Sciences
Daniel Kraus, Andreas Kleiber, Enrico Ehrhardt, Matthias Leifheit, Peter Horbert, Matthias Urban, Nils Gleichmann, Guenter Mayer, Juergen Popp, Thomas Henkel
Summary: Label-free and gentle separation of cell stages with desired target properties from mixed stage populations is an important research task in modern biotechnological cultivation process. The reported microfluidic sorter system (MSS) significantly increased the purity of target cells in the sorted population.
Article
Engineering, Chemical
Julia Sophie Boeke, Daniel Kraus, Thomas Henkel
Summary: Reliable operation of lab-on-a-chip systems relies on precise and predictable fluid management, with pressure-driven flow control simplifying the process and enabling automation. Predicting the required pressure settings for achieving desired flow rates simplifies control tasks and offers opportunities for creating multi-component laminar flows and droplets.
Article
Chemistry, Analytical
Tamas Vermes, Mark Kielpinski, Thomas Henkel, Miquel A. Pericas, Esther Alza, Angelica Corcuera, Helmut Buschmann, Thomas Goldner, Andreas Urban
Summary: A new automated microfluidic screening assay has been developed in this study, allowing for the measurement of compound EC50 values in very short incubation times and the discrimination of different classes of CAMs. The system also revealed an intermediate CAM-N/A behavior in certain screening compounds.
ANALYTICAL METHODS
(2022)
Article
Materials Science, Multidisciplinary
Chandan Singh, Matthias Thiele, Andre Dathe, Sophie Thamm, Thomas Henkel, Gajjala Sumana, Wolfgang Fritzsche, Andrea Csaki
Summary: A two-step process involving extraction and exchange reactions was used to immobilize gold nanocubes on a glass surface, resulting in improved sensitivity for microfluidic sensing of glucose concentrations.
Article
Chemistry, Analytical
Paul-Gerald Dittrich, Daniel Kraus, Enrico Ehrhardt, Thomas Henkel, Gunther Notni
Summary: The paper investigates the integration of standard imaging flow cytometry with filter-on-chip technology for spatial and spectral measurement, and its application in the development of a multispectral imaging flow cytometry platform. The results demonstrate the potential of this approach for characterizing and classifying bioparticles in-flow, with potential for further applications.
Article
Chemistry, Analytical
Thomas Henkel, Guenter Mayer, Joerg Hampl, Jialan Cao, Linda Ehrhardt, Andreas Schober, Gregor Alexander Gross
Summary: Droplet-based microfluidic screening techniques can be connected to established microtiter plate-based screening and sample management workflows through interfacing tools. A bidirectional sampling interface for sample transfer from wells into droplets and vice versa droplets into wells is achieved using Digital Microfluidic Pipetting Tips (DMPT) and a robotic system.
Article
Engineering, Electrical & Electronic
Daniel Kraus, Julia Sophie Boeke, Enrico Ehrhardt, Thomas Henkel
Summary: This article introduces a method called Multispectral Imaging Flow Cytometry (MIFC) for tracking morphological and compositional changes of single cells. By using multispectral imaging, the amount and distribution of substances inside the cells can be measured, which has important applications in cell cultivation processes.
MICRO AND NANO ENGINEERING
(2022)
Review
Biochemical Research Methods
Andreas Kleiber, Daniel Kraus, Thomas Henkel, Wolfgang Fritzsche
Summary: Conventional flow cytometry (FC) has evolved as a powerful measurement method in clinical diagnostics, biology, life sciences and healthcare within the last decades. Imaging flow cytometry (IFC) extends the power of traditional FC by adding high resolution optical and spectroscopic information. Tomographic imaging flow cytometry (tIFC) was developed to access 3D information about the target particles, aiming to visualize surfaces and internal structures in a holistic way.
Proceedings Paper
Optics
Paul-Gerald Dittrich, Daniel Kraus, Thomas Henkel, Jurgen Popp, Maik Rosenberger, Gunther Notni
Summary: The study extended imaging flow cytometry (IFC) with snapshot-mosaic cameras for in-flow characterization of bioparticles, allowing for analysis and counting of single cells and whole cell populations. The use of spatial and spectrally resolving snapshot-mosaic cameras and real time capable multivariate data processing expands the possibilities for automated analysis of mixed bioparticle populations. The microalgae Haematococcus pluvialis (HP) was used in the experiments to demonstrate the usability of the system.
MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XIX
(2021)
Article
Biochemical Research Methods
Andreas Kleiber, Anuradha Ramoji, Guenter Mayer, Ute Neugebauer, Juergen Popp, Thomas Henkel
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)