期刊
CHEMICAL ENGINEERING & TECHNOLOGY
卷 35, 期 1, 页码 17-34出版社
WILEY-BLACKWELL
DOI: 10.1002/ceat.201100281
关键词
Chiral resolution; Chiralpak (R) AD; Continuous chromatographic processes; Countercurrent moving bed chromatography; Enantiomer separation; Simulated moving bed; True moving bed
资金
- Fundacao para a Ciencia e Tecnologia
- Ministry of Science and Technology and Higher Education of Portugal [POCI/EQU/59296/2004]
- European Commission [251816]
- Fundação para a Ciência e a Tecnologia [POCI/EQU/59296/2004] Funding Source: FCT
This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE (R) unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration.
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